Injected self-healing hydrogel material capable of realizing ordered release of medicine

A hydrogel, injection-type technology, applied in the fields of drug delivery, pharmaceutical science, pharmaceutical formulation, etc., can solve the problems of shortening the life of the gel, affecting the structural integrity and mechanical properties of the gel, and achieving the induction of disease defect tissue repair, Good biocompatibility and quick release effect

Inactive Publication Date: 2016-08-10
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrogel injected into the organism is easily damaged by external force extrusion, body fluid erosion and other chemical substan

Method used

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  • Injected self-healing hydrogel material capable of realizing ordered release of medicine
  • Injected self-healing hydrogel material capable of realizing ordered release of medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Example 1: A preparation method of an injectable self-healing hydrogel material that can realize the orderly release of drugs

[0023] 1) Using 5 μg / mL bFGF aqueous solution as the inner aqueous phase, 40 mg / mL PLGA dichloromethane solution as the oil phase, and 2 wt% PVA aqueous solution as the outer aqueous phase, the growth factor-loaded PLGA microparticles were prepared by the double emulsion method. ball;

[0024] 2) Add 18mL of ethylenediamine to 10wt% gelatin solution, mix well, add concentrated hydrochloric acid to adjust the pH to 5.0, then add 5.35g of EDC, react the reaction system at 37°C for 6 hours, dialyze in deionized water, freeze-dry, Aminated gelatin is obtained;

[0025] 3) Add 3.0g sodium periodate to 10wt% dextran solution, react in the dark at 42°C for 8 hours, add 10 mL diethylene glycol to terminate the reaction, dialyze in deionized water, and freeze-dry to obtain oxidized dextran sugar;

[0026] 4) Dissolve 75 mg of aminated gelatin and 5 m...

Embodiment 2

[0027] Example 2: A preparation method of an injectable self-healing hydrogel material that can realize the orderly release of drugs

[0028] 1) Using 1 μg / mL bFGF aqueous solution as the inner aqueous phase, 30 mg / mL PLGA dichloromethane solution as the oil phase, and 1 wt% PVA aqueous solution as the outer aqueous phase, the growth factor-loaded PLGA microparticles were prepared by the double emulsion method. ball;

[0029] 2) Add 10mL of ethylenediamine to the 5wt% gelatin solution, mix well, add concentrated hydrochloric acid to adjust the pH to 6.0, then add 1.35g of EDC, react the reaction system at 37°C for 4 hours, dialyze in deionized water, freeze-dry, Aminated gelatin is obtained;

[0030] 3) Add 1.5g of sodium periodate to 5wt% dextran solution, react in the dark at 42°C for 6 h, then add 2 mL of diethylene glycol to terminate the reaction, dialyze in deionized water, and freeze-dry to obtain oxidized dextran sugar;

[0031] 4) Dissolve 50 mg of aminated gelatin...

Embodiment 3

[0032] Example 3: A preparation method of an injectable self-healing hydrogel material that can realize the orderly release of drugs

[0033] 1) Using 10 μg / mL hEGF aqueous solution as the inner aqueous phase, 80 mg / mL PLGA dichloromethane solution as the oil phase, and 2 wt% PVA aqueous solution as the outer aqueous phase, the growth factor-loaded PLGA microparticles were prepared by the double emulsion method. ball;

[0034] 2) Add 25mL of ethylenediamine to 20wt% gelatin solution, mix well, add concentrated hydrochloric acid to adjust the pH to 4.0, then add 8.0g of EDC, react the reaction system at 37°C for 8 hours, dialyze in deionized water, freeze-dry, Aminated gelatin is obtained;

[0035] 3) Add 6g of sodium periodate to 20wt% dextran solution, react in the dark at 42°C for 8 hours, add 10mL of diethylene glycol to terminate the reaction, dialyze in deionized water, and freeze-dry to obtain oxidized dextran;

[0036] 4) Dissolve 100 mg of aminated gelatin and 5 mg o...

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Abstract

The invention discloses an injected self-healing hydrogel material capable of realizing ordered release of a medicine as well as a preparation method and applications of the injected self-healing hydrogel material. The injected self-healing hydrogel material is composed of aminated gelatin, oxidized dextran, hydrogel prepared by adipic dihydrazide, antibiotic and PLGA microspheres loaded with growth factors. The hydrogel material prepared by the method provided by invention has the self-healing and ordered releasing functions, and the release of the antibiotic is rapid, so that the rapid inflammation diminishing effect can be realized; the growth factors wrapped by the microspheres release slowly, the tissue regeneration can be induced, and the injected self-healing hydrogel material is suitable for repairing the defected tissues such as the skin tissue, the periodontal tissue and the cartilage tissue.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an injection-type self-healing hydrogel material capable of realizing orderly drug release, a preparation method and application thereof. Background technique [0002] Histological defects are often accompanied by infection. To achieve regenerative repair of diseased defect tissue, the inflammation must be eliminated first. Therefore, there is an urgent clinical need to develop a drug carrier that can realize the orderly release of growth factors and antibiotics, so as to rapidly inhibit inflammation and continuously induce the regeneration and repair of diseased and defective tissues. [0003] Polymer hydrogel is a hydrophilic polymer network, which can absorb a large amount of water, and is insoluble in water due to the physical and chemical cross-linking between polymer chains, and has the function of maintaining its shape and three-dimensional network...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/20A61L27/54A61L27/18A61L27/58A61L27/52A61L27/60
CPCA61L27/18A61L27/20A61L27/24A61L27/52A61L27/54A61L27/58A61L27/60A61L2300/204A61L2300/232A61L2300/252A61L2300/404A61L2300/41A61L2300/412A61L2300/414A61L2300/602A61L2300/604A61L2400/06A61L2430/06C08L5/02C08L67/04
Inventor 陈名懋曹欢张其清刘园园宋飞飞程翠
Owner FUZHOU UNIVERSITY
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