Degradable composite surgical suture

Abstract

The invention provides a degradable composite surgical suture, wherein the surgical suture is prepared by a method comprising the following steps: S1, adding chitin and graphene oxide to dispersion liquid, so that a saturated solution is formed; freezing and thawing the saturated solution at low temperature, performing uniform stirring after melting, so that a mixed solution is obtained; S2, adding epoxy chloropropane, which serves as a cross-linking agent, to the mixed solution obtained in the step S1, conducting stirring and standing, so that a cross-linked product is obtained; S3, purifying the cross-linked product obtained in the step S2, dissolving the cross-linked product in formic acid, so that a spinning collagen solution is prepared, and spinning and shaping the spinning collagen solution; and S4, soaking a shaped product obtained in the step S3 in a nano silver solution, performing drawing and drying, and disinfecting, so that the surgical suture is obtained. The suture prepared by the invention can solve the problem of existing chitosan polysaccharide sutures which are relatively weak in mechanical strength; the surgical suture is relatively good in mechanical performance; and meanwhile, the surgical suture is capable of satisfying a suturing demand under an in vivo polar environment.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and more specifically relates to a degradable composite surgical suture. Background technique [0002] Existing CT sutures are generally prepared after acetylation of chitosan sutures, and chitosan and its derivative sutures are basically still used. The preparation and processing process is cumbersome, which limits the industrial application. [0003] At the same time, the existing CT or CTS sutures have poor mechanical properties, especially weak tensile strength, and cannot meet the clinical needs of high-strength sutures, especially for suturing in the strong acid environment of the stomach in vivo. Therefore, it is particularly important to seek and prepare a chitin surgical suture with proper mechanical strength properties. There have been reports on the preparation of composite materials such as chitosan, gelatin, polyvinyl alcohol, and AgNPs, but the preparation of CT / GO / AgNPs...

AI Technical Summary

Problems solved by technology

There have been reports on the preparation of composite materials such as chitosan and gelatin, polyvinyl alcohol, AgNPs, etc., but the preparation of CT / GO / AgNPs composite surgical sutures has not been reported yet.

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