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Preparation method of complex phase porous scaffold structure based on temperature regulation and control of complex phase apatite ingredients

A complex phase apatite and porous scaffold technology, applied in the field of biomedical materials, can solve problems such as complex process, and achieve the effect of simple process flow and easy operation

Inactive Publication Date: 2016-09-07
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of many technical defects such as the need to post-process the template in the prior art, the process is complicated, and the main component of the finished product is hydroxyapatite, the present invention proposes a multi-phase porous scaffold structure based on temperature-regulated multi-phase apatite composition The preparation method does not require ball milling. After heat treatment, the compound phase composition of hydroxyapatite and α-TCP is obtained. The biological performance of the prepared scaffold is good, and it is the best choice to replace the damaged hard tissue of the human body.

Method used

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  • Preparation method of complex phase porous scaffold structure based on temperature regulation and control of complex phase apatite ingredients
  • Preparation method of complex phase porous scaffold structure based on temperature regulation and control of complex phase apatite ingredients
  • Preparation method of complex phase porous scaffold structure based on temperature regulation and control of complex phase apatite ingredients

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Experimental program
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Effect test

Embodiment 1

[0031] This embodiment includes the following steps:

[0032] Step 1, weighing apatite, PMMA, SDS and ammonium bicarbonate according to the ratio of 8:6:11:3 parts by weight;

[0033] Step 2, putting hydroxyapatite, PMMA and SDS into a glass container, stirring evenly with a machine;

[0034] Step 3, dissolving ammonium bicarbonate in ultrapure water at a ratio of 1:1;

[0035] Step 4, drop the ammonium bicarbonate solution into the mixed powder, and stir evenly;

[0036] Step 6, put in an oven, dry at 70°C, take out the block after drying, and put it in a crucible;

[0037] Step 7, put the crucible into a high-temperature heating furnace, and raise the temperature to 600°C at 4°C / min for 0.5 hours;

[0038] Step 8, continue to heat up at 2°C / min to 800°C for 3 hours;

[0039] In step 9, the crucible is taken out after cooling with the furnace to obtain a porous scaffold composed of hydroxyapatite and α‐TCP (<5wt%) multiphase components.

[0040] This embodiment relates t...

Embodiment 2

[0043] This embodiment includes the following steps:

[0044] Step 1, weighing hydroxyapatite, PMMA, SDS and ammonium bicarbonate according to the ratio of 8:6:11:3 parts by weight;

[0045] Step 2, putting hydroxyapatite, PMMA and SDS into a glass container, stirring evenly with a machine;

[0046] Step 3, dissolving ammonium bicarbonate in ultrapure water at a ratio of 1:1;

[0047] Step 4, drop the ammonium bicarbonate solution into the mixed powder, and stir evenly;

[0048] Step 6, put in an oven, dry at 70°C, take out the block after drying, and put it in a crucible;

[0049] Step 7, put the crucible into a high-temperature heating furnace, and raise the temperature to 600°C at 4°C / min for 0.5 hours;

[0050] Step 8, continue to heat up at 2°C / min to 860°C for 5 hours;

[0051] Step 9, take out the crucible after cooling with the furnace, and obtain a porous scaffold of hydroxyapatite (58%) and α-TCP (42%) multiphase.

[0052] This embodiment relates to the XRD spec...

Embodiment 3

[0055] This embodiment includes the following steps:

[0056] Step 1, weighing hydroxyapatite, PMMA, SDS and ammonium bicarbonate according to the ratio of 8:6:11:3 parts by weight;

[0057] Step 2, putting hydroxyapatite, PMMA and SDS into a glass container, stirring evenly with a machine;

[0058] Step 3, dissolving ammonium bicarbonate in ultrapure water at a ratio of 1:1;

[0059] Step 4, drop the ammonium bicarbonate solution into the mixed powder, and stir evenly;

[0060] Step 6, put in an oven, dry at 70°C, take out the block after drying, and put it in a crucible;

[0061] Step 7, put the crucible into a high-temperature heating furnace, and raise the temperature to 600°C at 4°C / min for 1 hour;

[0062] Step 8, continue to heat up at 2°C / min to 900°C for 4 hours;

[0063] Step 9, after cooling with the furnace, take out the crucible to obtain a multi-phase porous scaffold composed of hydroxyapatite (55%) and α‐TCP (45%).

[0064]This embodiment relates to the XRD...

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Abstract

The invention provides a preparation method of a complex phase porous scaffold structure based on temperature regulation and control of complex phase apatite ingredients. According to the method, hydroxyapatite, polymethylmethacrylate and sodium dodecyl sulfate are uniformly mixed; an ammonium hydrogen carbonate solution is added dropwise into the mixture, and uniform stirring is performed; after the drying, heating is performed, and heat insulation is performed; and finally, the regulation and preparation of the complex phase apatite ingredients is realized through controlling the heat insulation temperature, i.e., the heat insulation temperature is in direct proportion to the content of the alpha-TCP complex phase ingredients in complex phase phosphorite. The preparation method has the advantages that ball milling is not needed in the process; the hydroxyapatite and alpha-TCP complex phase ingredients are obtained after the heating processing; the biological property of the prepared scaffold is good; and the prepared scaffold is an optimum choice for replacing human body injured sclerous tissues.

Description

technical field [0001] The invention relates to a technology in the field of biomedical materials, in particular to a method for preparing a multiphase porous scaffold structure based on temperature control of the multiphase apatite composition. Background technique [0002] Hydroxyapatite is the main inorganic component of human bones and teeth, so it has good biological activity and osteoinductivity. Porous hydroxyapatite not only has the characteristics of hydroxyapatite, but also has criss-cross pores, which promote the input of nutrients and the discharge of metabolites, thereby inducing bone cell attachment and growth, accelerating new bone formation, and repairing bone tissue defects. At present, the methods for preparing porous materials include template method, freeze-drying method, foaming method, and adding pore-forming agent. Contents of the invention [0003] In view of many technical defects such as the need to post-process the template in the prior art, the...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/56A61L27/58
CPCA61L27/425A61L27/56A61L27/58A61L2430/02
Inventor 饶群力饶曼琦
Owner SHANGHAI JIAO TONG UNIV
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