Soft tissue engineering porous scaffold and preparation method thereof

Abstract

The invention discloses a soft tissue engineering porous scaffold and a preparation method thereof. The soft tissue engineering porous scaffold is prepared by compositing sodium carboxymethylcellulose, chitosan and polyvinyl pyrrolidone, wherein the mass ratio of the sodium carboxymethylcellulose to the polyvinyl pyrrolidone ranges from 1:50 to 1:0.1, the mass ratio of the sodium carboxymethylcellulose to the chitosan ranges from 1:50 to 1:0.1, the thickness of the porous scaffold is 0.8 to 2.6mm, the porosity is 35.0% to 87.0%, and the tensile strength is 1.4MPa to 68.98MPa. The preparation method of the scaffold is environmentally friendly and non-toxic, the procedure of the preparation technology is simple, the cost is low, and the prepared scaffold is good in biocompatibility, can replace an artificial skin, is used as skin dressing and a skin tissue engineering material, and helps a patient with a large-area and deep skin burn to recover physiological functions lost because of skin injury under the condition of insufficient autologous skin.

Description

technical field [0001] The invention relates to a soft tissue engineering porous scaffold and a preparation method thereof. The porous soft tissue engineering scaffold can be applied to skin tissue engineering and belongs to the field of biomedical materials. Background technique [0002] Tissue-engineered skin refers to skin products composed of cells or extracellular matrix or a combination of the two. It is constructed by combining seed cells with appropriate scaffold materials by applying the principles and technologies of life science and engineering. A biological substitute for maintaining and improving the function and shape of damaged skin tissue. In recent years, with the rapid development of cell biology, molecular biology and biomaterials, tissue engineering has also made great progress, and the development of skin tissue engineering is particularly noticeable. Some tissue-engineered skin products have even been approved by the U.S. Food and Drug Administration (...

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Problems solved by technology

However, these processes have poor controllability, and it is difficult to construct scaffold microstructures with complex structures for multi-cell growth

[0003] Chitosan (CS) is a natural polymer with stable chemical properties, easy film formation, good biocompatibility, non-toxicity, anti-coagulation and other biological activities and excellent antibacterial properties. It can also prevent wound infection, promote granulation growth and skin regeneration, but the pure chitosan film has poor degradability, poor mechanical properties, high brittleness and unsuitability for acidic environments in practical applications.

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