An antiallergic compound flavone composition, and a preparing method and applications thereof

A compound flavonoid, anti-allergic technology, applied in the directions of drug combination, allergic diseases, preparations for skin care, etc., to achieve the effects of obvious effect, simple preparation process and easy operation

Inactive Publication Date: 2016-09-28
广州市络捷生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, research on the anti-allergic application of flavonoids basically stays in the aspect of single medicinal materials. However, human allergy is a complicated process, often a systemic multi-link reaction, and single medicinal materials are difficult to solve the main problem.

Method used

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  • An antiallergic compound flavone composition, and a preparing method and applications thereof
  • An antiallergic compound flavone composition, and a preparing method and applications thereof
  • An antiallergic compound flavone composition, and a preparing method and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] An anti-allergic compound flavonoid composition is prepared from the following Chinese medicinal materials in parts by weight: 40 parts by weight of licorice, 25 parts by chamomile, and 15 parts by weight.

[0044] The preparation method is as follows:

[0045] (1) Powdering: Glycyrrhizae, chamomile and Fangfeng are pulverized, then mixed evenly to obtain medicinal powder;

[0046] (2) Extraction: Add pure water 6 times its total weight to the medicinal powder, stir evenly, place in a low-temperature and high-pressure differential extractor, extract at -0.1MPa, 0°C, collect the extract for centrifugation, and collect Centrate;

[0047] (3) Separation and concentration: Use a 0.2 μm microfiltration membrane to remove impurities such as solid particles and bacteria, and then use a 100 Da flux ultrafiltration membrane for fractional purification, and the obtained retentate is concentrated to a specific gravity of 1.50.

[0048] The licorice of this embodiment: chamomile:...

Embodiment 2

[0050] An anti-allergic compound flavonoid composition is prepared from the following Chinese medicinal materials in parts by weight: 40 parts by weight of licorice, 25 parts by chamomile, and 35 parts by weight.

[0051] The preparation method is as follows:

[0052] (1) Powdering: Glycyrrhizae, chamomile and Fangfeng are pulverized and mixed evenly to obtain medicinal powder;

[0053] (2) Extraction: Add 50 times of its total weight to the medicinal powder with an ethanol aqueous solution with a volume ratio concentration of 10%, stir evenly, place it in a low-temperature and high-pressure differential extractor, extract at 70MPa and 25°C, and collect the extract Carry out centrifugation and collect the centrifugate;

[0054] (3) Separation and concentration: Use a 1.0 μm microfiltration membrane to remove impurities such as solid particles and bacteria, and then use a 20,000 Da flux ultrafiltration membrane for fractional purification, and the obtained retentate is concent...

Embodiment 3

[0057] An anti-allergic compound flavonoid composition is prepared from the following Chinese medicinal materials in parts by weight: 50 parts by weight of licorice, 30 parts by chamomile, and 20 parts by weight.

[0058] The preparation method is as follows:

[0059] (1) Powdering: Glycyrrhizae, chamomile and Fangfeng are pulverized and mixed evenly to obtain medicinal powder;

[0060] (2) Extraction: Add 70% ethanol aqueous solution with a volume ratio concentration of 20 times its total weight to the medicinal powder, stir evenly, place it in a low-temperature and high-pressure differential extractor, extract at 50MPa and 20°C, and collect the extract Carry out centrifugation and collect the centrifugate;

[0061] (3) Separation and concentration: Use a 1.0 μm microfiltration membrane to remove impurities such as solid particles and bacteria from the centrifugate, and then use a 1000 Da flux ultrafiltration membrane for fractional purification, and the obtained retentate i...

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Abstract

The invention relates to an antiallergic compound flavone composition. The composition is prepared from 1-50 parts by weight of liquorice root, 1-90 parts by weight of camomile and 5-80 parts by weight of divaricate saposhnikovia root. A preparing method and applications of the composition are also disclosed. Three active flavones of different structure types of the liquorice root, the camomile and the divaricate saposhnikovia root are reasonably compounded, and are synergistic. The composition has multi-level antiallergic effects.

Description

technical field [0001] The invention relates to a composite flavonoid composition, in particular to an anti-allergic composite flavone composition and its preparation method and application. Background technique [0002] Flavonoids are an active ingredient that widely exists in plants in nature. It has a wide variety of quantities and complex structure types, and has many important functions, such as: anti-oxidation, inhibition of enzyme activity, anti-cancer, anti-bacterial, anti-virus, anti-inflammation, and anti-diabetes. disease and so on. Especially in the field of anti-allergy, flavonoids play a pivotal role. Modern studies have proved that the anti-allergic mechanism of flavonoids is mainly by affecting cells closely related to allergic reactions (T cells, B cells, NK cells, macrophages, mast cells, basophils, neutrophils and eosinophils). cells, etc.), mitosis and cell-cell interactions. For example, Guangming Chinese Medicine [2014, 29 (9)] reported that flavonoi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P37/08A61K8/97A61Q19/00
CPCA61K8/97A61K36/238A61K36/28A61K36/484A61K2236/331A61K2236/333A61K2236/55A61Q19/00A61K2300/00
Inventor 郑伟东黄裕周锦珂吴少莉彭颖华廖家纯
Owner 广州市络捷生物科技有限公司
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