The invention relates to poly(2-cyanoacrylic acid) as well as a preparation method and application thereof, and belongs to the fields of
medicine and
chemical industry. The method comprises the following steps: firstly, preparing an alpha-
cyanoacrylate polymer, and selectively hydrolyzing ester bonds of the
polymer under alkaline conditions to obtain the poly(2-cyanoacrylic acid). The poly(2-cyanoacrylic acid) is dispersed into water to form negatively charged microspheres, so that novel blank
embolism microspheres are obtained, the particle sizes of the blank
embolism microspheres can be adjusted in a
micrometer range, and the blank
embolism microspheres have a deformation function to pass through blood vessels with specific morphology, and can tightly embolize the blood vessels to avoidectopic embolism due to shedding; and the blank embolism microspheres and a positively-charged
drug are combined to obtain novel
drug-loaded embolism microspheres, the novel
drug-loaded embolism microspheres use a
polymer carboxyl group to actively load the positively-charged drug by adopting the principle of charge reversal, and can directly release the drug in localized
pathological tissue, thedrug rarely flows through a
whole body, so that the local effect of the drug on the
pathological tissue is improved, and the toxic and side effects of the drug on the
whole body are reduced.