Medicine for preventing and treating senile dementia

A technology for Alzheimer's disease and drugs, applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve problems such as unsatisfactory treatment effects, achieve good promotion and application prospects, improve learning and memory function decline, and reduce the production of β-AP Effect

Inactive Publication Date: 2016-09-28
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Cannabidiol has also been documented in the treatment of Al...

Method used

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  • Medicine for preventing and treating senile dementia
  • Medicine for preventing and treating senile dementia
  • Medicine for preventing and treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The flowers, leaves, hemp bran and hemp seeds of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Take mature industrial hemp hemp seeds, dry, remove impurities, and crush them for later use; use ethanol to extract the crushed hemp seeds (at 60-85°C, heat and extract twice, each time for 1-3 hours ), the ethanol concentration is 95% to 100% (V / V), and the ratio of solid to liquid is 1:5 to 1:20; the extract is filtered out and concentrated under reduced pressure to obtain the industrial hemp hemp seed extract.

[0032] Take the mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 1:3:2, dry, remove impurities, and pulverize to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned pulverized industrial hemp raw materials into supercritical In the carbon dioxide extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, the extraction pressure i...

Embodiment 2

[0035] Repeat Example 1, with the following differences: when extracting industrial hemp hemp seeds with ethanol, extract at room temperature, and extract 2 times for each batch of materials, each for 7 to 10 days. A 1:1:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as a raw material for extracting hemp cannabinoids.

[0036] Get 0.3 part of industrial hemp hemp seed extract and 99.7 parts of industrial hemp cannabinoid, and mix well to obtain the required drug A for preventing and treating senile dementia.

Embodiment 3

[0038] Repeat Example 1, the following difference is arranged: when extracting industrial hemp hemp seed with ethanol, adopt ultrasonic assisted extraction, ultrasonic frequency 30~60kHz, power 100~1000W, extraction time 30~60min, leaching temperature 25~ 50°C. A 3:2:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as the raw material for extracting hemp cannabinoids.

[0039] Get 99.7 parts of industrial hemp hemp seed extract and 0.3 part of industrial hemp cannabinoid, and mix well to obtain the required drug C for preventing and treating senile dementia.

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Abstract

The invention discloses a medicine for preventing and treating senile dementia. The medicine is prepared by mixing 0.3-99.7 parts of industrial hemp semen cannabis extract and 0.3-99.7 parts of industrial hemp cannabinoid to be uniform. The pharmaceutical composition has an obvious relieving effect on spatial cognition disorder and study and memory function decline caused by senile dementia and cerebral ischemia, the content of inhibitory amino acid aspartic acid, glycine and gamma-aminobutyric acid on the cerebral cortex of a senile dementia rat can be increased, the toxicity of excitable glutamic acid can be reduced, generated beta-AP in AD rat hippocampus can be reduced, and an obvious relieving effect is achieved for memory function decline caused by cerebral ischemia; mouse dysmnesia caused by NaNO2 can be obviously relieved. All effects are superior to those of cannabidiol. The medicine has a definitely remarkable effect on preventing and treating senile dementia and has good application and popularization prospects.

Description

technical field [0001] The invention belongs to the field of drugs for treating senile dementia, and in particular relates to a pharmaceutical composition for preventing and treating senile dementia prepared from industrial hemp as a main raw material. Background technique [0002] The cultivation of hemp has a long history. In ancient times, hemp was mainly used to make and process ropes, fishing nets, clothing and paper-making raw materials, as well as oil and food. With the development and progress of society, people found that a toxic ingredient (tetrahydrocannabinol) in marijuana can make people addicted to hallucinations. Many countries in Europe and the United States have banned the cultivation of marijuana for a long time. Due to the high economic value of cannabis, by the 1980s, some European countries had researched and bred low-toxic cannabis varieties and promoted their cultivation. In 1990, the European Community took the lead in urgently revising the agricultu...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P25/28
CPCA61K36/60A61K2236/33A61K2236/333A61K2236/37A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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