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Method for producing water-insoluble organic acid by bipolar membrane electrodialysis

A bipolar membrane electrodialysis, water-insoluble technology, applied in electrodialysis, preparation of organic compounds, organic chemistry, etc., can solve the problems of high membrane stack resistance, poor conductivity of organic solvents, high energy consumption, and achieve clean production. , the effect of saving chemical raw materials, significant industrial application value and environmental benefits

Active Publication Date: 2016-09-28
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For organic acids with poor water solubility, bipolar membrane electrodialysis has been reported. For example, the journal Bipolar membrane electrodialysis in aqua-ethanol medium: Production of salicylic acid (bipolar membrane electrodialysis in aqua-ethanol medium: Membrane electrodialysis produces salicylic acid in a water-ethanol system), and the solubility of salicylic acid is increased by using a water-ethanol mixed system, but due to the poor conductivity of the organic solvent, the resistance of the membrane stack is large and the energy consumption is high
At the same time, this method is not suitable for organic acids such as phenylglycine, which are insoluble in water and general organic solvents.

Method used

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  • Method for producing water-insoluble organic acid by bipolar membrane electrodialysis
  • Method for producing water-insoluble organic acid by bipolar membrane electrodialysis
  • Method for producing water-insoluble organic acid by bipolar membrane electrodialysis

Examples

Experimental program
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Effect test

Embodiment 1

[0039] First, put 400mL of 0.3mol / L sodium sulfate solution in the electrode solution storage tank to serve as the electrode solution. The alkali storage tank is initially put into 400mL of 0.05mol / L sodium hydroxide to reduce the initial resistance. Keep a sufficient amount of 0.3mol / L sodium sulfate solution in the sodium sulfate storage tank of the feed liquid, pass it through the peristaltic pump into the two-compartment bipolar membrane electrodialysis membrane stack and then directly flow out into the acid storage tank. At the same time, the acid in the acid storage tank is passed through a peristaltic pump at the same flow rate as the acid chamber into the 100 mL 2mol / L sodium phenylglycinate solution to be processed. Before turning on the power, turn on the peristaltic pump and circulate the entire device for half an hour to eliminate the damage to the membrane caused by bubbles. After the power is turned on, use a stopwatch to count the time. During the operation of t...

Embodiment 2

[0041] First, put 400mL of 0.3mol / L sodium sulfate solution in the electrode solution storage tank to serve as the electrode solution. The alkali storage tank is initially put into 400mL of 0.05mol / L sodium hydroxide to reduce the initial resistance. Keep a sufficient amount of 0.3mol / L sodium sulfate solution in the sodium sulfate storage tank of the feed liquid, pass it through the peristaltic pump into the two-compartment bipolar membrane electrodialysis membrane stack and then directly flow out into the acid storage tank. At the same time, the acid in the acid storage tank is fed into the 100mL 2mol / L sodium phenylglycinate solution to be processed through the peristaltic pump at the same flow rate as the acid chamber. Before turning on the power, turn on the peristaltic pump and circulate the whole device for half an hour to eliminate the damage to the membrane caused by bubbles. After the power is turned on, use a stopwatch to count the time. During the operation of the ...

Embodiment 3

[0043] First, put 400mL of 0.3mol / L sodium sulfate solution in the electrode solution storage tank to serve as the electrode solution. The alkali storage tank is initially put into 400mL of 0.05mol / L sodium hydroxide to reduce the initial resistance. Keep a sufficient amount of 0.3mol / L sodium sulfate solution in the sodium sulfate storage tank of the feed liquid, pass it through the peristaltic pump into the two-compartment bipolar membrane electrodialysis membrane stack and then directly flow out into the acid storage tank. At the same time, the acid in the acid storage tank is passed through the peristaltic pump at the same flow rate as the acid chamber into the 100 mL 2mol / L sodium phenylglycinate solution to be processed. Before turning on the power, turn on the peristaltic pump and circulate the whole device for half an hour to eliminate the damage to the membrane caused by bubbles. After the power is turned on, use a stopwatch to count the time. During the operation of ...

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Abstract

The invention relates to a method for producing water-insoluble organic acid by bipolar membrane electrodialysis. The method comprises the steps that a sodium sulfate aqueous solution is pumped into a bipolar membrane electrodialysis device to produce sulfuric acid and sodium hydroxide, the produced sulfuric acid is used for acidifying water-insoluble organic acid sodium salt to produce the water-insoluble organic acid and sodium sulfate, the produced water-insoluble organic acid solid is filtered and collected to obtain the required product, and the sodium sulfate aqueous solution used as a filtrate is used as a feed liquid to form a closed production loop. By the adoption of the method for producing the water-insoluble organic acid by the bipolar membrane electrodialysis, the full-closed and cycled clean production of the water-insoluble organic acid such as phenylglycine can be realized, so that chemical materials can be saved and a large number of high salinity wastewater can be avoided, the environmental pollution is reduced, and industrial application values and environmental benefits are obvious.

Description

Technical field [0001] The invention relates to a method for producing non-water-soluble organic acids by bipolar membrane electrodialysis. technical background [0002] Amino acid is an important organic compound. It is the basic substance that constitutes the protein required for animal nutrition. It is widely used in many industries such as medicine, food, chemical industry, agriculture, and environmental protection. Among them, phenylglycine, as a fine chemical product, has developed rapidly in recent years. It is widely used as an important side chain intermediate of the antibiotics ampicillin, cephalexin and their derivatives for the preparation of β-lactam antibiotics. [0003] The synthetic preparation methods of phenylglycine include phenylhydantoin method, glyoxylic acid method, phenylacetic acid method, biological enzymatic method, chloroform method and phase transfer catalysis method. At present, the phenylhydantoin process is widely used because of its simple principl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D61/48B01D61/52C07C229/36C07C227/18C07C65/10C07C51/41
CPCB01D61/48B01D61/52C07C51/412C07C227/18C07C229/36C07C65/10
Inventor 徐铜文周永明汪耀明
Owner UNIV OF SCI & TECH OF CHINA
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