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Gel emplastrum matrix and preparation method and application thereof

A plaster and gel technology, which is applied to the gel plaster base and the fields of preparation and use thereof, can solve the problems of unfavorable industrialized production, poor economic benefit, easy to fall off, etc., and achieves good skin followability, low cost, Easy to operate effect

Inactive Publication Date: 2016-10-12
成都抚南医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the above-mentioned existing gel plaster matrix has low initial adhesion, can only stick to the No. 6 steel ball, and is prone to fall off in practical applications. At the same time, its swelling time is as long as several hours, which takes a long time. And need boiling water bath heating, energy consumption is big, production cost is high, economic benefit is poor, is unfavorable for industrialized production

Method used

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  • Gel emplastrum matrix and preparation method and application thereof
  • Gel emplastrum matrix and preparation method and application thereof
  • Gel emplastrum matrix and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Gel plaster matrix, it is made up of the component of following mass parts:

[0091] Partially neutralized sodium polyacrylate (NP-800): 5.2 parts, pullulan: 0.57 parts, aluminum glycolate: 0.29 parts, glycerin: 30 parts, disodium edetate: 0.20 parts, tartaric acid: 0.55 parts , Galantan: 0.49 parts, purified water: 68 parts.

[0092] According to the above ratio, take tartaric acid, add purified water, stir to dissolve, then add pullulan, continue to stir until it becomes a uniform solution, and obtain phase A; 1. Partially neutralize sodium polyacrylate and galadan, stir evenly, and obtain phase B;

[0093] The above-mentioned phase A is quickly added to the above-mentioned phase B, and stirred at a slow speed for 6-10 minutes to obtain a viscous colloid (gel plaster base); the above-mentioned viscous colloid is coated on the backing material. The paste content is 24g / 100cm 2 , cutting, packaging, that is.

Embodiment 2

[0095] Gel plaster matrix, it is made up of the component of following mass parts:

[0096] Partially neutralized sodium polyacrylate (NP-700): 4.9 parts, pullulan: 1.23 parts, aluminum glycerol: 0.14 parts, glycerin: 29 parts, disodium edetate: 0.09 parts, tartaric acid: 0.26 parts , Galantan: 0.4 parts, purified water: 68 parts.

[0097] According to the above ratio, take tartaric acid, add purified water, stir to dissolve, then add pullulan, continue to stir until it becomes a uniform solution, and obtain phase A; 1. Partially neutralize sodium polyacrylate and galadan, stir evenly, and obtain phase B;

[0098] The above-mentioned phase A is quickly added to the above-mentioned phase B, and stirred at a slow speed for 6-10 minutes to obtain a viscous colloid (gel plaster base); the above-mentioned viscous colloid is coated on the backing material. The paste content is 30g / 100cm 2 , cutting, packaging, that is.

Embodiment 3

[0100] Gel plaster matrix, it is made up of the component of following mass parts:

[0101] Partially neutralized sodium polyacrylate (NP-600): 5.24 parts, pullulan: 2.25 parts, aluminum glycerol: 0.28 parts, glycerin: 26 parts, disodium edetate: 0.19 parts, tartaric acid: 0.55 parts , Galantan: 0.42 parts, purified water: 70 parts.

[0102] According to the above ratio, take tartaric acid, add purified water, stir to dissolve, then add pullulan, continue to stir until it becomes a uniform solution, and obtain phase A; 1. Partially neutralize sodium polyacrylate and galadan, stir evenly, and obtain phase B;

[0103] The above-mentioned phase A is quickly added to the above-mentioned phase B, and stirred at a slow speed for 6-10 minutes to obtain a viscous colloid (gel plaster base); the above-mentioned viscous colloid is coated on the backing material. The paste content is 34g / 100cm 2 , cutting, packaging, that is.

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Abstract

The invention discloses a gel plaster base, which comprises the following components in parts by mass: 4.0-6.0 parts of partially neutralized sodium polyacrylate, 0.2-2.5 parts of pullulan, and 0.12-2 parts of glyoxate 0.30 parts, 20-30 parts of glycerin, 0.08-0.20 parts of disodium edetate, 0.20-0.60 parts of tartaric acid, 0.3-0.5 parts of galadan, 60-75 parts of water. The gel plaster matrix of the present invention has the advantages of high initial adhesion, good formability, good skin followability, and no irritation to the skin, and is very suitable for preparing gel plasters; meanwhile, the gel plaster of the present invention The preparation method of the ointment base is simple, easy to operate, short in time, low in energy consumption and low in cost, and is very suitable for industrial production.

Description

technical field [0001] The invention relates to a gel plaster base, a preparation method and application thereof. Background technique [0002] According to the record of "Chinese Pharmacopoeia" 2010 edition, an appendix Ⅱ plaster (also known as cataplasm or cataplasm), gel plaster refers to the mixture of extracts, decoction pieces or chemical drugs and gel plaster matrix. After uniformity, apply the plaster prepared on the backing material. [0003] Among them, the gel plaster matrix has a very important influence on the performance of the gel plaster, and it is the key to preparing a gel plaster with excellent performance. [0004] Existing gel plaster matrix, such as the disclosed gel plaster matrix of Chinese patent CN 103142561 A, it is to mix sodium polyacrylate, sodium carboxymethyl cellulose, gum arabic and gelatin of formula quantity, mix uniformly, disperse in 1 / 2 of the formula amount in water, swell for 2 hours, then add the formula amount of glycerin and the ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K47/36A61K47/10A61K47/18A61K47/12A61K47/22
CPCA61K9/7023A61K47/10A61K47/12A61K47/183A61K47/22A61K47/32A61K47/36
Inventor 艾华杨琴王文渊张鸿程
Owner 成都抚南医药有限公司
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