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Novel composite material for drug carrier, as well as preparation method and application thereof

A composite material and carrier technology, which is applied in drug delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of inability to achieve long-term, slow release of drugs, instant release, etc., and achieve outstanding drug loading effect and drug release The effect of smooth rate and easy control of process conditions

Inactive Publication Date: 2016-10-12
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydroxyapatite also has great disadvantages as a carrier. The disadvantage is that it will be released instantaneously in the early stage of the drug release process, and the effect of long-term and slow drug release cannot be achieved.

Method used

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  • Novel composite material for drug carrier, as well as preparation method and application thereof
  • Novel composite material for drug carrier, as well as preparation method and application thereof
  • Novel composite material for drug carrier, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A novel composite material used as a drug carrier, prepared from the following raw materials in parts by mass:

[0036] 29 parts eggshell powder

[0037] Ammonium dihydrogen phosphate 250 parts

[0038] 3 parts of graphene oxide.

[0039] The preparation method of the above-mentioned novel composite material for drug carrier comprises the following steps:

[0040] 1) Weigh 0.29g eggshell powder and 0.03g graphene oxide according to the above proportioning ratio;

[0041] 2) Weigh 5.0g of ammonium dihydrogen phosphate, dissolve it in 50mL of deionized water, and prepare 50mL of 0.1g / mL ammonium dihydrogen phosphate solution;

[0042] 3) Measure 25.0 mL of ammonium dihydrogen phosphate solution, ultrasonically disperse the eggshell powder in the standard solution of ammonium dihydrogen phosphate, then add graphene oxide, and stir evenly to obtain a mixture;

[0043] 4) Pour the mixture into a 50mL polytetrafluoroethylene reactor, raise the temperature of the reactor t...

Embodiment 2

[0046] A novel composite material used as a drug carrier, prepared from the following raw materials in parts by mass:

[0047] 34 parts of eggshell powder

[0048] Ammonium dihydrogen phosphate 252 parts

[0049] 3 parts of graphene oxide.

[0050] The preparation method of the above-mentioned novel composite material for drug carrier comprises the following steps:

[0051] 1) Weigh 0.34g eggshell powder and 0.03g graphene oxide according to the above proportioning ratio;

[0052] 2) Weigh 5.0g of ammonium dihydrogen phosphate, dissolve it in 50mL of deionized water, and prepare 50mL of 0.1g / mL ammonium dihydrogen phosphate standard solution;

[0053] 3) Measure 25.2 mL of diammonium hydrogen phosphate solution, ultrasonically disperse the eggshell powder in the standard solution of ammonium dihydrogen phosphate, then add graphene oxide and stir evenly to obtain a mixture;

[0054] 4) Pour the mixture into a 50mL polytetrafluoroethylene reactor, raise the temperature of th...

Embodiment 3

[0056] A novel composite material used as a drug carrier, prepared from the following raw materials in parts by mass:

[0057] 35 parts of eggshell powder

[0058] Ammonium dihydrogen phosphate 249 parts

[0059] 2 parts of graphene oxide.

[0060] The preparation method of the above-mentioned novel composite material for drug carrier comprises the following steps:

[0061] 1) Weigh 0.35g eggshell powder and 0.02g graphene oxide according to the above proportioning ratio;

[0062] 2) Weigh 5.0g of ammonium dihydrogen phosphate, dissolve it in 50mL of deionized water, and prepare 50mL of 0.1g / mL ammonium dihydrogen phosphate standard solution;

[0063] 3) Measure 24.9 mL of diammonium hydrogen phosphate solution, ultrasonically disperse the eggshell powder in the standard solution of ammonium dihydrogen phosphate, then add graphene oxide and stir evenly to obtain a mixture;

[0064]4) Pour the mixture into a 50mL polytetrafluoroethylene reactor, raise the temperature of the...

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Abstract

The invention discloses a novel composite material for a drug carrier, as well as a preparation method and application thereof. The material is prepared from the following raw materials: egg shell powder, ammonium dihydrogen phosphate and graphene oxide in a certain ratio. The preparation method comprises the following steps: (1) weighing egg shell powder, ammonium dihydrogen phosphate and graphene oxide; (2) preparing an ammonium dihydrogen phosphate standard solution; (3) ultrasonically dispersing the egg shell powder into the ammonium dihydrogen phosphate standard solution, adding graphene oxide, and uniformly stirring to obtain mixture; and (4) pouring the mixture in a reaction kettle, heating the reaction kettle to 80-140 DEG C, reacting for 18-30 hours, cooling the product obtained after reaction to room temperature, washing and drying. The novel composite material has excellent biocompatibility and a large specific surface area, so that the drug loading performance is greatly improved, the drugs can be slowly and effectively released, and the material can be used as a drug carrier. The preparation method is simple, is convenient to operate, and has low preparation cost.

Description

technical field [0001] The invention belongs to the technical field of drug carriers in living organisms in biomedicine, and in particular relates to a novel composite material used for drug carriers and its preparation method and application. Background technique [0002] Since the 1970s, the research on drug carriers in vivo has been developed to a great extent. At present, many scientists are still studying the use of biocompatible and easily degradable compounds as drug carriers. [0003] Hydroxyapatite (HAP, Ca 10 (PO 4 ) 6 (OH) 2 ) is a new type of bio-inorganic material, which has the same composition as human bones, so it has good biocompatibility and strength, and it has a large specific surface area, so it has strong adsorption capacity and carrying capacity. With the continuous development of biomedicine and the improvement of preparation technology, various HAP materials will be widely used in clinical practice. The hydroxyapatite system as a drug carrier ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K47/46A61K31/192
CPCA61K9/0002A61K31/192A61K47/02A61K47/46
Inventor 李玲刘雅娜孙珂珂时振男
Owner HUBEI UNIV
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