Synthesis method of gold nanosheets and application of gold nanosheets in diagnosis and treatment of breast cancer

Abstract

The invention discloses a method for synthesizing gold nanosheets, belonging to the technical field of gold nanosheets, comprising the following steps: 1) synthesizing monodisperse silicon dioxide nanosheets; 2) performing surface modification on monodisperse silicon dioxide nanosheets; 3) Surface adsorption of silicon dioxide nanosheets to chloroauric acid ions; 4) synthesis of hard template silicon dioxide sheets; 5) etching of hard template silicon dioxide sheets to generate monodisperse gold nanosheets. The gold nanosheet synthesis method of the present invention provides a new idea for the synthesis of noble metal nanomaterials. The gold nanosheet synthesized by the method of the present invention is used in the diagnosis and treatment of breast cancer, and the signal amplification is carried out through SERS enhancement to monitor cancer cells, and at the same time The unique near-infrared absorption function enables gold nanosheets to integrate monitoring and treatment in the treatment of breast cancer, thus improving the application value of this material.

Description

technical field [0001] The invention belongs to the technical field of gold nanosheets, and in particular relates to a synthesis method of gold nanosheets and an application of gold nanosheets in diagnosis and treatment of breast cancer. Background technique [0002] In recent years, noble metal nanomaterials have attracted more and more attention due to their excellent performance in catalysis, electronics, and chemical sensing. At the same time, many shortcomings of noble metal nanoparticles are gradually exposed, such as high surface energy, easy agglomeration during the reaction process, limited resources and no regeneration. [0003] In order to optimize the properties of precious metals to reduce production costs and improve resource utilization, researchers have proposed two solutions. The first is to synthesize a variety of nanoparticles by means of controlled growth to increase the properties of precious metals. , such as palladium nanosheets and gold nanocages hav...

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Problems solved by technology

However, the core-shell structure also exposes a very serious problem, that is, the characteristics of the catalyst are reduced or hidden due to the packaging of inorganic materials, such as the low catalytic reaction efficiency of the catalyst and the weakening of the SERS signal.

[0004] In recent years, although noble metal nanoparticles have been supported on various inorganic materials, there have been no reports of noble metal nanoparticles supported on silica sheets, especially the synthesis of silica nanosheets.

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