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Chitosan styptic powder and preparation method thereof

A technology of hemostatic powder and chitosan, which is applied in medical science, bandages, etc., can solve the problems of inconspicuous analgesic effect, complicated organic reagents, and high overall cost, and achieve improved hemostatic and analgesic effect, simplified treatment process, and increased analgesic effect Effect

Inactive Publication Date: 2016-11-16
HENAN TUOREN BEST MEDICAL DEVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emulsification and cross-linking method is often used in the preparation process, and the use of organic reagents is complicated. For the later sample processing process, the process is complicated and easy to cause environmental pollution.
The overall cost is high and expensive, but the hemostatic effect is similar, and the analgesic effect is not obvious or has no such effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Dissolve 2g of sodium alginate and 0.5g of carboxymethyl chitosan into 60mL and 50mL of distilled water respectively, add the carboxymethyl chitosan solution to the sodium alginate solution, stir and mix well, and then add 40mL of 1.0g calcium chloride solution , Fully agitate, cross-link to form a hydrogel system, let stand for precipitation, discard the supernatant, wash 3 times with distilled water, to pH 5.0-7.0, vacuum dry, grind, sieving, and powder, the powdery solid Add 0.4mg of thrombin, mix well, grind into powder, irradiate and sterilize packaging to become hemostatic and analgesic powder.

[0018] In the rat femoral artery and liver hemorrhage model, the hemostatic powder produced was significantly better than Yunnan Baiyao and other similar products. The tail flick test in mice proved that the analgesic effect was good.

Embodiment 2

[0020] Dissolve 5g of sodium alginate and 1g of carboxymethyl chitosan into 150mL and 100mL of distilled water respectively, add the carboxymethyl chitosan solution to the sodium alginate solution, stir and mix well, and then add 80mL of 2.5g calcium chloride solution, Stir fully to cross-link to form a hydrogel system, stand for precipitation, discard the supernatant, wash 3 times with distilled water, to pH 5.0-7.0, vacuum dry, grind, sieving, and powder into the powdery solid Add 1mg of thrombin, mix well, irradiate and sterilize the package to become hemostatic and pain-relieving powder.

[0021] In the rat femoral artery and liver hemorrhage model, the hemostatic and pain-relieving powder produced was significantly better than Yunnan Baiyao and other similar products. The tail flick test in mice proved that the analgesic effect was good.

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Abstract

The invention relates to chitosan styptic powder and a preparation method thereof. The chitosan styptic powder is prepared from, by weight, 0.1-10 parts of carboxymethyl chitosan, 0.1-10 parts of sodium alginate and 0.0004-0.0005 part of thrombin in a mixing mode. A pain relieving effect is added based on a traditional styptic effect, and the styptic and analgesic effect is obviously improved. On a preparing process, a cross-linking method is adopted, the cross-linking environment is purified water, no organic reagent is related, purified water is adopted and no organic reagent is related in the post treatment process, the treatment process is greatly simplified, and the safety of the product is greatly improved.

Description

Technical field [0001] The invention belongs to the technical field of biomedical materials, and specifically relates to a chitosan hemostatic powder and a preparation method thereof. Background technique [0002] Bleeding is the first cause of death in war injuries and the second cause of death in trauma. Bleeding is also the main cause of death in operating rooms of trauma patients. Rapid and effective control of bleeding can significantly reduce deaths caused by excessive bleeding; Timely and rapid analgesia can significantly reduce the pain caused by pain to injured patients. Hemostasis can reduce blood loss during the operation, keep the operation field clear, prevent important tissue damage, ensure the safety of the operation, and heal the postoperative wound, reduce infection, and shorten the operation time. It is of great significance to the prognosis of patients; pain is a protective response produced by the body after noxious stimuli, and it is often accompanied by emot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0052A61L26/0066A61L2300/402A61L2300/418C08L89/00C08L5/08C08L5/04
Inventor 刘洁崔景强徐鹏乐牛利卫郝国梁
Owner HENAN TUOREN BEST MEDICAL DEVICE CO LTD
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