Vascular stent coating with drug sustained-release function and preparation method thereof

Abstract

The invention discloses a vascular stent coating with a drug sustained-release function, which is prepared from the following raw materials: polycaprolactone, chitosan, collagen, medicine, nano magnesium, nano titanium dioxide, dendrobium polysaccharide, tea polyphenol, dopamine, gelatin, nano zirconia, hirudin, and ethanol. The invention also discloses a preparation method of the vascular stent coating with the drug sustained-release function. The binding strength of the vascular stent coating and a substrate is 4.8 to 5.9 MPa, the binding strength of the vascular stent coating and the stent substrate is high, the degradation time of the vascular stent coating is 68 to 86 days, the vascular stent coating can be completely degraded after 90 days, the large-area shedding and swelling phenomena do not occur in the degradation process, the stability and biocompatibility are good, no cell toxicity, coagulation and thrombosis are formed, and no inflammatory response is generated.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a vascular stent coating with drug slow-release function and a preparation method thereof. Background technique [0002] In vascular interventional procedures, such as endarterectomy, peripheral arterial access angioplasty, coronary angioplasty and stent implantation are mainly used to treat arterial occlusive diseases, however, implanted vascular stents lead to restenosis, resulting in The blood vessel is occluded again, and at the same time, it also causes adverse problems such as vascular intima injury and local inflammatory response. In order to solve this problem, the implanted stent is often coated with a coating loaded with anti-inflammatory drugs. However, due to the fast blood flow in the blood vessel, the drug-loaded coating is placed in the blood vessel exposed to the fast flow, and it is easy to get rid of it in a very short time. The drug lo...

AI Technical Summary

Problems solved by technology

[0002] In vascular interventional procedures, such as endarterectomy, peripheral arterial access angioplasty, coronary angioplasty and stent implantation, etc. are mainly used to treat arterial occlusive diseases, however, implanted vascular stents lead to restenosis, resulting in The blood vessel is reoccluded, and at the same time, it also causes adverse problems such as damage to the intima of the blood vessel, local inflammatory response, etc.

In order to solve this problem, the implanted stent is often coated with a coating loaded with anti-inflammatory drugs. However, due to the fast blood flow in the blood vessel, the drug-loaded coating is placed in the blood vessel exposed to the fast flow, and it is easy to get rid of it in a very short time. The drug loaded in the coating is released, but the damaged blood vessel has not repaired and healed in this very short time, so the coated drug-loaded coating has a greatly reduced effect on inhibiting restenosis

In addition, although the slow-release drug-loaded coatings in the prior art have some improvements in alleviating restenosis of some blood vessels, problems such as shedding and swelling will occur during the degradation process of the drug-loaded coatings, and the stability is not good, which is greatly improved. limit its clinical application