Calcium carbonate tablets and preparation technology thereof

A preparation process and a technology for calcium carbonate tablets, applied in the field of health food, can solve the problems of low calcium apparent absorption rate and increased bone density, etc.

Active Publication Date: 2016-12-07
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is mainly used to promote cartilage growth, the effect of increasing bone d...

Method used

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  • Calcium carbonate tablets and preparation technology thereof
  • Calcium carbonate tablets and preparation technology thereof
  • Calcium carbonate tablets and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] prescription:

[0046]

[0047] The particle size of the calcium carbonate is 80nm.

[0048] Preparation:

[0049] (1) Adhesive solution preparation

[0050] Weigh the prescribed amount of hydroxypropylmethylcellulose, disperse and dissolve it with ethanol to obtain the hypromellose ethanol solution; weigh the prescribed amount of starch, disperse it with purified water, add Tween 80, and take another boiling purified water Rush into it quickly to obtain starch paste; pour the hydroxypropyl methylcellulose ethanol solution into the starch paste, stir well and set aside;

[0051] (2) Granulation

[0052] Weigh calcium carbonate, diethyl phthalate, polyethylene glycol 6000, protein sugar and castor oil according to the prescription, put them into the wet granulator together, and mix well; pour the binder solution in step (1) into Mix uniform raw and auxiliary materials, make soft materials, stir, and make granules;

[0053] (3) Drying and granulation

[0054] The...

Embodiment 2

[0060] prescription:

[0061]

[0062] The particle size of the calcium carbonate is 160nm.

[0063] Preparation:

[0064] (1) Adhesive solution preparation

[0065] Weigh the prescribed amount of hydroxypropylmethylcellulose, disperse and dissolve it with ethanol to obtain the hypromellose ethanol solution; weigh the prescribed amount of starch, disperse it with purified water, add Tween 80, and take another boiling purified water Rush into it quickly, obtain starch paste; Wherein, the weight ratio of hydroxypropyl methylcellulose and ethanol is 1:3, and the weight ratio of hydroxypropyl methylcellulose and purified water is 1:4; Pour the ethanol solution into the starch paste, stir well and set aside;

[0066] (2) Granulation

[0067] Weigh calcium carbonate, diethyl phthalate, polyethylene glycol 6000, protein sugar and castor oil according to the prescription, put them into the wet granulator together, and mix well; pour the binder solution in step (1) into Mix uni...

Embodiment 3

[0075] prescription:

[0076]

[0077]

[0078] The particle size of the calcium carbonate is 90nm.

[0079] Preparation:

[0080] (1) Adhesive solution preparation

[0081] Weigh the prescribed amount of hydroxypropylmethylcellulose, disperse and dissolve it with ethanol to obtain the hypromellose ethanol solution; weigh the prescribed amount of starch, disperse it with purified water, add Tween 80, and take another boiling purified water Rush into it quickly, obtain starch paste; Wherein, the weight ratio of hydroxypropyl methylcellulose and ethanol is 1:4, and the weight ratio of hydroxypropyl methylcellulose and purified water is 1:5; Pour the ethanol solution into the starch paste, stir well and set aside;

[0082] (2) Granulation

[0083] Weigh calcium carbonate, diethyl phthalate, polyethylene glycol 6000, protein sugar and castor oil according to the prescription, put them into the wet granulator together, and mix well; pour the binder solution in step (1) in...

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Abstract

The invention relates to health care food, in particular to calcium carbonate tablets. The calcium carbonate tablets are prepared from, by weight, 55-80 parts of calcium carbonate, 10-18 parts of starch, 0.02-0.1 part of diethyl phthalate, 0.01-0.1 part of polyethylene glycol 6000, 0.1-0.2 part of castor oil, 1.0-2.0 parts of hydroxypropyl methyl cellulose, 0.2-1.5 parts of tween-80, 1.5-2.5 parts of sodium carboxymethyl starch, 0.5-1.5 parts of silicon dioxide, 0.5-2.0 parts of magnesium stearate and 0.1-0.3 parts of protein sugar, wherein the particle size of calcium carbonate ranges from 80 nm to 160 nm. The calcium carbonate tablets are short in disintegration time, high in calcium apparent absorption rate and capable of effectively increasing the bone density.

Description

technical field [0001] The invention relates to a health food, in particular to a calcium carbonate tablet and a preparation process thereof. Background technique [0002] Osteoporosis is one of the common bone diseases in clinical practice. It is a metabolic disease characterized by low bone mass and the destruction of fine structure of bone tissue, resulting in increased bone fragility, decreased bone density, and easy fractures. bone disease. The eating habits of Chinese residents are also likely to lead to insufficient calcium intake, and with the increase of the elderly population in our country, the incidence of osteoporosis is also becoming more and more serious. Osteoporosis has become a health problem that has attracted much attention. [0003] There are many reasons for osteoporosis, among which the lack of calcium is one of the important factors. Calcium is closely related to bone density. It is one of the main components of bone. Under the regulation of the hom...

Claims

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Application Information

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IPC IPC(8): A23L33/16
CPCA23V2002/00A23V2200/306
Inventor 陈敏李旭丰何奔周春艳
Owner ZHUHAI TONGYUAN PHARMA CO LTD
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