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A pharmaceutical composition for external use

A technology for externally used drugs and compositions, which is applied in the direction of drug combinations, antineoplastic drugs, and pharmaceutical formulations, and can solve the problems that there are no reports on the combined use of timolol and allantoin, so as to overcome the problems of adverse reactions, Improve curative effect and overcome irritating effect

Active Publication Date: 2019-07-23
BEIJING MERSON PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In the currently published literature, there is no report on the combined use of timolol and allantoin

Method used

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  • A pharmaceutical composition for external use
  • A pharmaceutical composition for external use
  • A pharmaceutical composition for external use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047]

[0048] Preparation process: The oily and oil-soluble components (liquid paraffin, stearic acid, glycerol monostearate) in the recipe are heated together to about 80 °C to form an oil solution (oil phase), and the water-soluble components (glycerol) , sodium hydroxide) dissolved in water and heated together to 80 ℃ into an aqueous solution (water phase). When the oil phase is mixed with the water phase, the water phase is added to the oil phase. After stirring for 30 minutes, add timolol maleate, allantoin, and ethyl hydroxybenzoate in sequence, continue stirring for 30 minutes, and cool to room temperature under stirring to obtain timolol maleate cream.

Embodiment 2

[0050]

[0051] Preparation process: The oily and oil-soluble components in the recipe (methyl silicone oil, stearic acid, and cetostearyl alcohol) are heated together to about 75 °C to form an oil solution (oil phase), and the water-soluble components (horse Timolol, propylene glycol, allantoin, glycerol polyethylene glycol-75-stearate, ethyl paraben) were dissolved in water and heated together to 70°C to form an aqueous solution (aqueous phase). When the oil phase is mixed with the water phase, after stirring for 30 minutes, the mixture is cooled to room temperature under stirring to obtain a timolol maleate cream.

Embodiment 3

[0053]

[0054] Preparation process: The oily and oil-soluble components (liquid paraffin) in the prescription are heated to about 30 ° C to form an oil solution (oil phase), and the water-soluble components (HPMC, timolol maleate, propylene glycol, urine Cystin, polysorbate 80, paraben / propyl ester) were dissolved in water and heated together to 30°C to form an aqueous solution (aqueous phase). The oil phase is mixed with the water phase, and after stirring for 30 minutes, the timolol maleate cream is obtained.

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Abstract

The invention relates to a pharmaceutical composition for external use. The pharmaceutical composition is characterized by simultaneously containing timolol and allantoin, wherein, timolol can be a free alkali form, and also can be an any pharmaceutically acceptable salt form. The composition preparation has good stability and permeability, and has obvious curative effect for infantile hemangioma.

Description

technical field [0001] The present invention relates to a pharmaceutical composition comprising timolol and allantoin, more particularly to a compound external cream or gel of timolol hydrochloride, timolol maleate and allantoin . Background technique [0002] Infantile hemangioma (IH) is the most common benign tumor in childhood, with a neonatal incidence of 10%-12% and a male to female ratio of 1:3-1:5. It is usually divided into superficial type, deep type and mixed type according to the location of the lesion; according to the development process of the lesion, it is divided into the proliferative phase, the regression phase and the complete regression phase. The typical clinical manifestations of infantile hemangioma are rapid proliferation within 1 year after birth, and then gradually regress slowly. [0003] Although infantile hemangioma can regress on its own, about 10% of children still suffer from serious complications such as ulcers, infection, pain, and even bl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5377A61K9/06A61P35/00A61P9/00A61K31/4166
CPCA61K9/06A61K31/4166A61K31/5377A61K47/32A61K47/38A61K47/44A61K2300/00
Inventor 赵锡龙李银博林秀
Owner BEIJING MERSON PHARMA CO LTD
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