Method for preparing titanium/hydroxyapatite biological scaffold through die-free direct-write molding technology

A technology of hydroxyapatite and direct writing molding, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of high technical requirements, low compressive strength, and harsh conditions for biological scaffolds, and achieve adjustable compression resistance Strength, improved mechanical properties, adjustable composition

Inactive Publication Date: 2016-12-07
SHENZHEN UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to provide a method for preparing titanium/hydroxyapatite bioscaffolds by moldless direct writing molding technology, aiming to solve the probl

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  • Method for preparing titanium/hydroxyapatite biological scaffold through die-free direct-write molding technology

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Embodiment Construction

[0013] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer, the present invention will be further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0014] An embodiment of the present invention provides a method for preparing a titanium / hydroxyapatite bioscaffold by a moldless direct writing technique, comprising the following steps:

[0015] S01. Dispersing the mixed powder of hydroxyapatite powder and metal titanium powder in the medium to make a titanium / hydroxyapatite ceramic slurry with a solid phase content of 50-80wt%;

[0016] S02. Pre-design the three-dimensional structural diagram through CAD software, and convert it into a code language recognizable by the computer, put the titanium / hydroxyapatite ceramic slurry into the ext...

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Abstract

The invention provides a method for preparing a titanium/hydroxyapatite biological scaffold through the die-free direct-write molding technology. The method comprises the following steps: the mixed powder of hydroxyapatite powder and titanium metal powder is dispersed into a medium, so as to prepare a titanium/hydroxyapatite ceramic slurry with the solid phase content of 50-80wt percent; a three-dimensional structural map is designed in advance through a CAD software, and then converted to be code language capable of being recognized by a computer, the titanium/hydroxyapatite ceramic slurry is placed into an extruding needle cylinder, under the driving of a three-dimensional platform, the extruding needle cylinder moves along the path appointed by the computer and extrudes for formation layer by layer and simultaneously, therefore, a multilayer ordered three-dimensional porous network-like structure green body is formed; and procedures of drying, sintering and heat treating are performed on the multilayer ordered three-dimensional porous network-like structure green body, and a three-dimensional biological scaffold is obtained.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a method for preparing a titanium / hydroxyapatite biological scaffold by a moldless direct writing molding technique. Background technique [0002] The composition and physical and chemical properties of hydroxyapatite are similar to the inorganic components of human bones. It has good biocompatibility and bioactivity, and can induce new bone formation. It is a widely used material in inorganic bioceramics. The three-dimensional porous hydroxyapatite structure is widely used in the preparation of biomimetic materials. However, the disadvantages of hydroxyapatite bioscaffolds are high brittleness and low compressive strength, so they can only be used for bone replacement in non-load-bearing parts. [0003] The molding technology of conventional biological scaffolds mostly needs to use laser beam or ultraviolet radiation in the molding process, and it is carrie...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/06A61L27/10A61L27/56
CPCA61L27/12A61L27/06A61L27/10A61L27/56A61L2430/02
Inventor 李亚运熊信柏曾燮榕黄传威马俊
Owner SHENZHEN UNIV
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