Method for extracting Hemerocallis citrina colchicine by aid of press-shear assisted interaction technology

A technology for the interaction between narcissin and micro-cutting aids, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., and can solve the constraints on the research, development and application of effective active ingredients in plants, and can not be applied to industrial production practices , Poor water solubility of active ingredients and other issues, to speed up the speed of osmotic dissolution and diffusion, improve the rate of cell wall breaking, and shorten the extraction time

Inactive Publication Date: 2016-12-07
唐翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, many domestic and foreign scholars have continuously explored and optimized the extraction process of plant effective active ingredients, and some new extraction and separation technologies have emerged, such as microwave, ultrasonic, ultrafine pulverization, supercritical, etc. Although these new Technology has made significant progress compared with traditional technology, but the problems of poor water solubility and low utilization of active ingredients have not been fundamentally solved, and some technologies are limited to laboratory research due to special equipment, and cannot be applied to industrial production practice
It can be seen that the imperfection of extraction technology has always been a key issue restricting the further research, development and application of effective plant active ingredients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The method for extracting narcissine assisted by micro-cutting and interaction technology comprises the following steps:

[0019] (1) Take the yellow flower and wash it, then dry it under vacuum conditions, control the water content of the dried yellow flower to be below 5%, then crush the dried yellow flower, pass it through a 30-mesh sieve, and obtain the yellow flower powder;

[0020] (2) Put yellow pollen and sodium carbonate into a planetary mill or vibratory mill for 20 minutes in a weight ratio of 95:5 to obtain mixed micropowder;

[0021] (3) Put the mixed micropowder and 60% ethanol into a single-stage continuous countercurrent ultrasonic extraction machine according to the material-to-liquid ratio of 1g: 12ml, and perform ultrasonic countercurrent extraction for 25 minutes under the action of ultrasonic waves with a frequency of 60KHz, a power of 400w, and a temperature of 40°C , filter the extract, collect the filtrate and filter residue; repeat the ultrasoni...

Embodiment 2

[0025] The method for extracting narcissine assisted by micro-cutting and interaction technology comprises the following steps:

[0026] (1) Take the yellow flower and wash it, then dry it under vacuum conditions, control the water content of the dried yellow flower to be below 5%, then crush the dried yellow flower, pass it through a 40-mesh sieve, and obtain the yellow flower powder;

[0027] (2) Put yellow pollen and sodium carbonate into a planetary mill or a vibrating mill for 10 minutes at a weight ratio of 96:4 to obtain a mixed micropowder;

[0028] (3) Put the mixed micropowder and 65% ethanol into a single-stage continuous countercurrent ultrasonic extraction machine according to the material-to-liquid ratio of 1g: 15ml, and perform ultrasonic countercurrent extraction for 15 minutes under the action of ultrasonic waves with a frequency of 80KHz, a power of 300w, and a temperature of 50°C , filter the extract, collect the filtrate and filter residue; repeat the ultra...

Embodiment 3

[0032] The method for extracting narcissine assisted by micro-cutting and interaction technology comprises the following steps:

[0033] (1) Take the yellow flower and wash it, then dry it under vacuum conditions, control the water content of the dried yellow flower to be below 5%, then crush the dried yellow flower, pass it through a 50-mesh sieve, and obtain the yellow flower powder;

[0034] (2) Put yellow pollen and sodium carbonate in a planetary mill or vibratory mill for 30 minutes in a weight ratio of 98:2 to obtain mixed micropowder;

[0035] (3) Put the mixed micropowder and 50% ethanol into a single-stage continuous countercurrent ultrasonic extraction machine according to the material-to-liquid ratio of 1g: 10ml, and perform ultrasonic countercurrent extraction for 10 minutes under the action of ultrasonic waves with a frequency of 30KHz, a power of 450w, and a temperature of 60°C , filter the extract, collect the filtrate and filter residue; repeat the ultrasonic ...

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PUM

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Abstract

The invention discloses a method for extracting colchicine from Hemerocallis citrina by aid of press-shear assisted interaction technology, including: washing, drying and crushing Hemerocallis citrina to obtain Hemerocallis citrina powder; mixing and grinding the Hemerocallis citrina and sodium carbonate to obtain mixed micro-powder; placing the micro-powder in a single-stage continuous countercurrent ultrasonic extractor to carry out ethanol extraction; finally, subjecting extracted filtrate to vacuum distillation and drying to obtain the Hemerocallis citrina colchicine. Compared with the prior art, the Hemerocallis citrina colchicine is extracted by the aid of Hemerocallis citrina colchicine, the ability of colchicine to dissolve in an ethanol solution can be effectively improved in the superfine powder state, and separation rate of colchicine is further increased; in the ethanol extraction process of colchicine, ultrasonic action is aided by continuous countercurrent extraction technology, osmic dissolution and diffusion speed in the colchicine extraction process can be increased, extraction time is shortened, the usage of a solvent can be reduced, and the method is a colchicine extraction method high in efficiency and low in consumption.

Description

technical field [0001] The invention belongs to the technical field of extraction of plant effective components, and in particular relates to a method for assisting the extraction of narcissin by using a micro-cutting-aided interaction technique. Background technique [0002] Natural plants are increasingly favored by people because of their rich resources, less toxic and side effects, no drug resistance, and no harmful residues. The ingredients contained in natural plants are very complex, which can be divided into active ingredients, ineffective ingredients and toxic ingredients. Active ingredients include terpenoids, glycosides, organic acids and trace elements. There are many extraction methods for effective active ingredients of natural plants, and the traditional extraction methods mainly include decoction, dipping, and reflux extraction. The decoction method is convenient and easy, but there are many impurities in the decoction liquid, which is prone to mildew and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/24C07C233/32A61K36/896
CPCC07C231/24A61K36/896C07C233/32
Inventor 唐翔
Owner 唐翔
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