Feed additive and feed

A feed additive and feed technology, applied in the direction of animal feed, additional food elements, applications, etc., can solve the problems of uneven product quality, ulcers, negative effects, etc.

Inactive Publication Date: 2017-01-04
HUNAN JINGTIAN TECH IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the growth-promoting effect of cysteamine on growing and finishing pigs is dose-dependent. Within a certain dose range, with the increase of cysteamine dose in the diet, the effect of increasing daily gain and reducing feed-to-weight ratio is more obvious , but reached or exceeded a certain dose, but it showed a certain negative effect; the reason may be that high doses of cysteamine lowered the pH of gastric juice, thereby causing ulcers
[0006] At present, there are many coating cysteamine manufacturers, and the product quality varies. In the coating process, the product particles required by the feed additives must be small, otherwise they will be mixed unevenly. This puts forward very high requirements for the coating process, and to achieve Requirements, equipment investment is large, coating cost is high, and the current cysteamine has the problem of causing gastrointestinal mucosal ulcers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Add 500kg of dichloromethane and 154kg of cysteamine into a 2000L enamel reaction kettle, cool down to 0-5°C with frozen brine, slowly add 204kg of acetyl chloride (over 30%), and drop 200kg of triethylamine at the same time to maintain the temperature Reaction at 0-5°C, when no cysteamine can be detected, stop the reaction, raise the temperature to 38-45°C, distill out dichloromethane for recovery (recycling), add 1000kg of cold water, and separate 200kg of N-acetylcysteamine , detected by liquid chromatography, the content was 99.1% (N-acetyl cysteamine standard sample was purchased from SIGMA, USA), and the yield was 97.9%.

Embodiment 2

[0031] Add 500kg of dichloromethane and 154kg of cysteamine into a 2000L enamel reaction kettle, cool down to 0-5°C with frozen brine, slowly add 277kg of butyryl chloride (over 30%), and dropwise add 200kg of triethylamine to keep the temperature Reaction at 0-5°C, when no cysteamine can be detected, stop the reaction, raise the temperature to 38-45°C, distill out dichloromethane for recovery (recycling), add 1000kg of cold water, and separate 255kg of N-butyryl cysteamine , detected by liquid chromatography, the content was 99.4% (N-butyryl cysteamine standard sample was purchased from SIGMA, USA), and the yield was 98.1%.

Embodiment 3

[0033]Add 500kg of dichloromethane and 154kg of cysteamine into a 2000L enamel reaction kettle, cool down to 0-5°C with frozen brine, slowly add 782kg of oleoyl chloride (over 30%), and drop 200kg of triethylamine at the same time to maintain the temperature Reaction at 0-5°C, when no cysteamine can be detected, stop the reaction, raise the temperature to 38-45°C, slip out the dichloromethane for recovery (recycling), add 1000kg of cold water, and separate 635kg of N-oleoyl cysteamine , detected by liquid chromatography, the content was 98.2% (N-oleoyl cysteamine standard sample was purchased from SIGMA, USA), and the yield was 96.3%.

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Abstract

The application of the invention provides a feed additive. The feed additive comprises N-acyl cysteamine compounds. The N-acyl cysteamine compounds provided by the application of the invention are preferentially selected and obtained by a reaction of cysteamine and acyl chloride. The application further provides a feed. The N-acyl cysteamine compounds are added in the feed of the application, and an acyl group is taken as a protecting group of the cysteamine, so that the N-acyl cysteamine compounds have no irritation, and do not cause gastrointestinal mucosal ulcers, furthermore, the N-acyl cysteamine compounds are slowly decomposed into the cysteamine to take effect under the action of pancreatic lipase, and can be used as animal growth promoters, so that the animal growth can be promoted and the weight gain rate and the feed conversion rate can be improved.

Description

technical field [0001] The invention relates to the technical field of feed, in particular to feed additives and feed. Background technique [0002] Cysteamine, also known as β-mercaptoethylamine, is the decarboxylation product of cysteine ​​and is a component of coenzyme A molecule. Cysteamine can specifically reduce the biological activity of somatostatin SS, regulate growth hormone, insulin, glucagon, thyroid hormone and T 4 The secretion of hormones such as protein, thereby regulating the metabolism of nutrients such as protein, fat and carbohydrates. Due to the presence of -SH and -NH in cysteamine 2 It is easy to be oxidized in the air, so cysteamine is generally prepared in the form of hydrochloride or coated into microcapsules, etc. and directly mixed in the feed, which can not only improve the survival rate and growth rate of piglets, but also affect the future growth rate of piglets. Production performance can have a positive impact. [0003] Studies have shown...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/10
Inventor 周建成
Owner HUNAN JINGTIAN TECH IND CO LTD
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