Resveratrol external use gel and preparation method thereof

A technology of resveratrol and gel, which is applied in the field of resveratrol gel for external use and its preparation, can solve the problems of resistance, insufficient pharmacological activity, and low bioavailability, so as to expand the route of administration, improve Drug bioavailability, effect of increasing effective blood drug concentration

Inactive Publication Date: 2017-01-04
LESHAN VOCATIONAL & TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Resveratrol has a variety of pharmacological activities, however, there is a huge resistance in practical application
The oral bioavailability of traditional resveratrol is low, its metabolism is rapid in the body, and the blood drug concentration is far lower than the effective concentration of in vitro experiments, so it is not enough to exert the corresponding pharmacological activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A resveratrol gel for external use, its formula components are: Polygonum cuspidatum extract resveratrol 0.05g, carbomer 9400.14g, sodium metabisulfite 0.01g, propylene glycol 1.6g, triethanolamine 0.24g, p-hydroxybenzene Methyl formate 0.2g, laurocapram 0.02g, purified water 17.74g.

[0023] (1) Dissolve 0.14g of Carbomer 940 in 17.74g of purified water and stir to form a transparent gel;

[0024] (2) Add 0.01g sodium metabisulfite and 1.6g propylene glycol to the transparent gel obtained in step (1), stir evenly;

[0025] (3) Get 0.05g Polygonum cuspidatum extract resveratrol and dissolve it in an appropriate amount of ethanol to obtain a resveratrol solution;

[0026] (4) Add the resveratrol solution obtained in step (3) to the solution obtained in step (2), then add 0.2g methyl p-hydroxybenzoate, 0.24g triethanolamine and 0.02g laurocaprazine, stir The resveratrol gel for external use is obtained after uniformity.

[0027] During the preparation process, when sti...

Embodiment 2

[0029] A resveratrol gel for external use, its formula components are: chemically synthesized resveratrol 0.1g, carbomer 9400.14g, sodium metabisulfite 0.01g, propylene glycol 1.6g, triethanolamine 0.24g, p-hydroxybenzoic acid Methyl ester 0.1g, laurocapram 0.02g, purified water 17.79g.

[0030] (1) Dissolve 0.14g of Carbomer 940 in 17.79g of purified water and stir to form a transparent gel;

[0031] (2) Add 0.01g sodium metabisulfite and 1.6g propylene glycol to the transparent gel obtained in step (1), stir evenly;

[0032] (3) Dissolve 0.1 g of chemically synthesized resveratrol in an appropriate amount of ethanol to obtain a resveratrol solution;

[0033] (4) Add the resveratrol solution obtained in step (3) to the solution obtained in step (2), then add 0.1g methyl p-hydroxybenzoate, 0.24g triethanolamine and 0.02g laurocaprazine, stir The resveratrol gel for external use is obtained after uniformity.

[0034] During the preparation process, when stirring, the stirrin...

Embodiment 3

[0036] A resveratrol gel for external use, its formula components are: resveratrol 0.02g, carbomer 934 0.4g, sodium metabisulfite 0.02g, propylene glycol 10g, triethanolamine 1.0g, methyl p-hydroxybenzoate 0.1g, laurocaprazine 0.04g, purified water 188.42g.

[0037] (1) Dissolve 0.4g of Carbomer 934 in 188.42g of purified water and stir to form a transparent gel;

[0038] (2) Add 0.02g sodium metabisulfite and 10g propylene glycol to the transparent gel obtained in step (1), stir evenly;

[0039] (3) Dissolve 0.02g resveratrol in an appropriate amount of ethanol to obtain a resveratrol solution;

[0040] (4) Add the resveratrol solution obtained in step (3) to the solution obtained in step (2), then add 0.1g methyl p-hydroxybenzoate, 1.0g triethanolamine and 0.04g laurocaprazine, stir The resveratrol gel for external use is obtained after uniformity.

[0041] During the preparation process, when stirring, the stirring speed is 100-300r / min, and the temperature is 25-30°C. ...

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PUM

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Abstract

The invention discloses resveratrol external use gel and a preparation method thereof. The resveratrol external use gel is prepared from the following materials: 0.01 percent to 5 percent of resveratrol, 0.2 percent to 1.5 percent of carbomer, 5 percent to 15 percent of propanediol, 0.01 percent to 0.1 percent of sodium pyrosulfite, 0.5 percent to 2.0 percent of triethanolamine, 0.05 percent to 1 percent of methyl p-hydroxybenzoate, 0.02 percent to 2 percent of laurocapram and 73.4 percent to 94.21 percent of pure water. A modern preparation technology is used; the resveratrol external use gel is prepared by taking the carbomer as a gel substrate;; the medication route of the resveratrol is expanded; the bioavailability of the medicine for treating body surface skin diseases is improved. The resveratrol external use gel is suitable for human skin and mucosa local medication. Compared with oral medication, the resveratrol external use gel has the advantages that the effective blood concentration of local affected parts is greatly improved; the medicine bioavailability is improved.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a resveratrol gel for external use and a preparation method thereof. Background technique [0002] Resveratrol is a class of non-flavonoid polyphenolic compounds. Such substances widely exist in higher plants in nature, and are plant defensins produced when plants resist natural hazards such as fungal infection, ultraviolet radiation and other unfavorable conditions, and play a protective role on the plants themselves. Modern research shows that resveratrol has a variety of pharmacological activities, such as inhibiting cell proliferation, anti-inflammation, anti-bacterial and fungal infection, anti-oxidation, anti-aging and two-way regulation of immunity. [0003] Resveratrol has a variety of pharmacological activities, however, there is a huge resistance in practical application. Oral oral bioavailability of traditional resveratrol is low, its metabolism in the ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/32A61K31/05A61P17/00
CPCA61K9/06A61K9/0014A61K31/05A61K47/32
Inventor 徐娇龚涛
Owner LESHAN VOCATIONAL & TECHN COLLEGE
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