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Dental pulp regeneration paste and preparing method thereof

A paste and dental pulp technology, which is applied in the field of pulp regeneration paste and its preparation, can solve the problems of loss of pulp nutrition, sensation, defense and formation functions, prone to fracture, and reduced strength, etc. Blood supply, avoid secondary damage, easy to operate

Inactive Publication Date: 2017-01-04
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to aim at root canal treatment, which will cause the tooth to lose the nutrition, sensation, defense and formation functions of the pulp due to the pulpless state, the strength will be significantly reduced, and it will easily become brittle and prone to fracture, resulting in tooth loss, etc. A series of problems, to invent a pulp regeneration paste that can not only preserve the living pulp but also cure diseases such as pulpitis, and provide its preparation method at the same time

Method used

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  • Dental pulp regeneration paste and preparing method thereof
  • Dental pulp regeneration paste and preparing method thereof
  • Dental pulp regeneration paste and preparing method thereof

Examples

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Effect test

Embodiment 1

[0030] The dental pulp regeneration paste of this embodiment includes a paste base and active ingredients, the active ingredients are as follows: 10 g of Yunnan Baiyao, 10 g of metronidazole, 10 g of ciprofloxacin, 0.01 g of insulin-like growth factor 1, and 0.01 g of estradiol And chitosan 5g, paste base is 35mL olive oil.

[0031] The dental pulp regeneration paste of the present embodiment is prepared by the following method:

[0032] 1) Grind Yunnan Baiyao, metronidazole, ciprofloxacin, insulin-like growth factor 1, estradiol and chitosan according to a certain weight ratio into fine powder, and pass through a 100-mesh sieve;

[0033] 2) mixing the powder prepared above with the oral paste base until creamy, to obtain a uniformly stirred paste preparation;

[0034] 3) Sterilize and repack the obtained paste preparation;

[0035] 4) Store the subpackaged sterilizing paste in a dry, cool and dark place for later use.

Embodiment 2

[0037] The dental pulp regeneration paste of this embodiment includes a paste matrix and active ingredients, and the active ingredients are as follows: 25g of Yunnan Baiyao, 25g of metronidazole, 25g of ciprofloxacin, 0.5g of insulin-like growth factor 1, and 0.5g of estradiol And chitosan 14g, paste base is 135mL olive oil.

[0038] The preparation method is the same as in Example 1.

Embodiment 3

[0040] The dental pulp regeneration paste of this embodiment includes a paste base and active ingredients, and the active ingredients are as follows: 40 g of Yunnan Baiyao, 40 g of metronidazole, 40 g of ciprofloxacin, 1 g of insulin-like growth factor 1, 1 g of estradiol and shell Polysaccharide 20g, paste base is 170mL methyl silicone oil.

[0041] The preparation method is the same as in Example 1.

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Abstract

The invention provides dental pulp regeneration paste. The dental pulp regeneration paste comprises an active component, and the active component is prepared from, by weight, 10-40 parts of Yunnan Baiyao, 10-40 parts of metronidazole, 10-40 parts of ciprofloxacin, 0.01-1 part of insulin-like growth factor1, 0.01-1 part of estradiol and 5-20 parts of chitosan. The dental pulp regeneration paste has the following advantages that compared with traditional root canal therapy, the dental pulp regeneration paste is easy for oral cavity clinicians to operate and short in treatment time when used clinically, the number of times of further consultation of patients is small, and the treatment efficiency of dental pulp diseases is greatly improved. As mechanical root canal preparation is not needed, secondary damage to the root canal wall tissue is avoided, and the risk of odontagma is reduced.

Description

technical field [0001] The invention belongs to the technical field of dental therapeutic drugs, in particular to a paste that can preserve the living pulp and promote tissue regeneration when treating diseases such as pulpitis, and the paste can be placed on the pulp tissue to activate stem cells in the pulp tissue Proliferation and differentiation potential, improve the anti-inflammation, tissue repair and regeneration capabilities of dental pulp tissue, eliminate local pulp tissue inflammation, and restore normal physiological functions of dental pulp and dental tissue. Background technique [0002] Pulpitis, periapical periodontitis and other diseases are common and frequently-occurring diseases in modern people. Bacteria penetrate into the inside of the tooth, causing the soft pulp cells to infect and die. At present, root canal therapy (commonly known as tooth-killing nerve) is used to debride and eliminate infection in oral clinical practice. Root canal therapy has pl...

Claims

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Application Information

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IPC IPC(8): A61K38/30A61K9/06A61P1/02A61K31/045A61K35/55A61K31/565A61K31/722A61K31/4164A61K31/496A61K36/898
CPCA61K9/0063A61K9/06A61K31/045A61K31/4164A61K31/496A61K31/565A61K31/722A61K35/55A61K36/258A61K36/898A61K38/30A61K47/44A61K2300/00
Inventor 于金华庞希瑶周洲金琳
Owner AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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