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Biological absorbable three-dimensional printing strontium-contained mesoporous bioactive glass support and preparation method thereof

A technology of bioglass and three-dimensional printing, applied in the field of biomedical materials, to achieve strong mechanical properties, good bone formation ability, and the effect of promoting osteogenesis ability

Active Publication Date: 2017-01-04
上海浩渤医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] No literature has reported a bioabsorbable 3D-printed strontium-containing mesoporous bioglass scaffold

Method used

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  • Biological absorbable three-dimensional printing strontium-contained mesoporous bioactive glass support and preparation method thereof
  • Biological absorbable three-dimensional printing strontium-contained mesoporous bioactive glass support and preparation method thereof
  • Biological absorbable three-dimensional printing strontium-contained mesoporous bioactive glass support and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of a bioabsorbable 3D-printed strontium-containing mesoporous bioglass scaffold

[0035] Preparation of a bioabsorbable three-dimensional printed strontium-containing mesoporous bioglass scaffold, comprising the following steps:

[0036] Step 1, preparing strontium-containing bioactive glass powder, passing through a 400-mesh sieve to make the size smaller than 37 μm, and storing it dry for later use;

[0037]For the preparation method of strontium-containing bioactive glass powder, please refer to the literature Zhang J, Zhao S, Zhu Y, et al.Three-dimensional printing of strontium-containing mesoporous bioactiveglass scaffolds for bone regeneration[J].Acta Biomaterialia,2014,10(5) :2269-2281. Preferably 5% of Sr-MBG.

[0038] Step 2, dissolving polycaprolactone (PCL, molecular weight 70,000-90,000, purchased from Sigma-Aldrich) in chloroform, magnetic stirring for 2 hours, and sealing for future use;

[0039] Step 3: Add the strontium-containin...

Embodiment 2

[0042] Example 2: Adhesion of MC3T3-E1 cells on bioabsorbable 3D-printed strontium-containing mesoporous bioglass scaffolds

[0043] MC3T3-E1 cells (mouse embryonic osteoblast precursor cells) were purchased from the Cell Bank of the Chinese Academy of Sciences.

[0044] Three-dimensionally printed strontium-containing mesoporous bioglass scaffold material samples were soaked in 75% medical alcohol for 4 hours, and then sterilized under ultraviolet light for 24 hours. At the same time, 1ml of α-MEM containing 10% FBS was added to the 24-well plate for culture The substrate was pre-wetted for 24 hours, the medium was replaced, and then the sterilized scaffold material was transferred into a 24-well plate. Then, will contain 1×10 5 200 μl of culture medium of MC3T3-E1 cells was added dropwise to each sample, and incubated at 37°C, 5% CO 2 Atmosphere CO 2 Cultivate in an incubator, and after 8 hours the cells basically adhere to the wall, add 1 ml of α-MEM medium containing 10...

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Abstract

The invention discloses a biological absorbable three-dimensional printing strontium-contained mesoporous bioactive glass support and belongs to the field of biological medical materials. The bone tissue engineering support is prepared from strontium(Sr)-contained mesoporous bioactive glass (Sr-MBG) and polycaprolactone (PCL), wherein the weight proportion of the Sr-MBG to the PCL is 70% and 30%, and 5% of Ca in the Sr-MBG is replaced by the Sr. The bone tissue engineer support is prepared by a three-dimensional printing technique, the two materials of the Sr-MBG and the PCL are printed into the cuboid-shaped bioactive support layer by layer, the layers are formed by criss-cross perpendicular lines, and the holes formed by the perpendicular lines are in square shapes and is favorable for bone cells and new vessels to grow into. The biological absorbable three-dimensional printing strontium-contained mesoporous bioactive glass support can be applied to bone defect repair and treatment, has good biocompatibility and better osteogenic improving capacity, can be absorbed and degraded by living organisms and is suitable for serving as an ideal support material in bone tissue engineering.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a bioabsorbable three-dimensionally printed strontium-containing mesoporous bioglass bracket. Background technique [0002] Severe bone trauma or bone tumor resection often leaves large or small bone defects, and clinicians need to use various bone repair materials to fill and repair them. Although autologous bone grafting has always been the "gold standard" for repairing bone defects, it has disadvantages such as increased trauma, limited bone mass, and complications at the donor site. application. Finding materials with good biocompatibility, osteoconductivity and osteoinductivity has become a research direction in the field of bone tissue repair. [0003] Bioactive glass, referred to as bioglass, is a synthetic bone tissue replacement material, which contains Ca 2+ with PO in biological fluids 4 3- to SiO 2 The gel layer diffuses, deposits, and gradually mineralizes, ...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/56A61L27/10A61L27/18B33Y80/00B33Y70/00
Inventor 禹宝庆朱钰方张旭裴鹏
Owner 上海浩渤医疗科技有限公司
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