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A natural medicinal composition for treating osteoporotic fracture and/or osteoarthritis and its application

A natural medicine, osteoarthritis technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of side effects and curative effects, to solve the side effects and poor curative effect, and eliminate the synovial fluid of the knee joint. Effects of inflammatory cells

Active Publication Date: 2020-02-21
ZHEJIANG INNOVATION WISDOM VALLEY TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to overcome the defects in the above-mentioned prior art, the object of the present invention is to provide a natural medicinal composition for treating osteoporotic fractures and / or osteoarthritis and its application, the natural medicinal composition is compatible, safe in dose, The effect is obvious, and it can effectively solve the problems of side effects and poor efficacy of existing Chinese and Western medicines in the treatment of osteoporotic fractures and / or osteoarthritis

Method used

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  • A natural medicinal composition for treating osteoporotic fracture and/or osteoarthritis and its application
  • A natural medicinal composition for treating osteoporotic fracture and/or osteoarthritis and its application
  • A natural medicinal composition for treating osteoporotic fracture and/or osteoarthritis and its application

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preparation example Construction

[0029] The preparation method of raw material preparation of the present invention can adopt following three kinds:

[0030] 1) The preparation of seabuckthorn fruit oil, common methods are as follows:

[0031] ①Physical pressing and centrifugal separation: Seabuckthorn fruit juice and seabuckthorn fruit puree are obtained by pressing (removing seeds) from ripe fresh seabuckthorn fruits (seeded) through an air screw rod. The fruit puree is soaked in warm water at 50-55°C for 2-3 times, lightly soaked for 60 minutes, centrifuged and purified several times, and the oil extraction rate of seabuckthorn fruit oil is 0.07%-4.0% (g / g).

[0032] ② CO 2 Supercritical extraction: sea buckthorn ripe fresh fruit (seed removed), obtained sea buckthorn fruit puree. Extraction conditions for industrial production: extraction pressure 35MPa, extraction temperature 45°C. The extraction time is 1.5h, and the separation temperature is 45°C. The oil extraction rate can reach 5.2% (g / g). Add ...

Embodiment 1

[0042] The natural medicine composition for treating osteoporotic fractures and / or osteoarthritis is composed of a medicament prepared from raw materials in the following mass percentages: 94.6% seabuckthorn fruit oil, 5.4% total notoginseng saponins.

Embodiment 2

[0044] The natural medicinal composition for treating osteoporotic fractures and / or osteoarthritis, the composition is composed of a medicament prepared from the following raw materials by mass percentage: 87.2.% of seabuckthorn fruit oil, 12.8% of Panax notoginseng saponins .

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Abstract

The invention discloses a natural medicine composition for treating osteoporotic fractures and / or osteoarthritis and its application, and belongs to the technical field of research on the dose-effect and action-use of the compatibility of natural medicine prescriptions. The natural medicine composition consists of 73.3%-98.3% of seabuckthorn fruit oil and 1.7%-26.7% of Panax notoginseng saponins in terms of mass percentage. The natural medicine composition can convert signal molecules producing eicosatrienoic acid in vivo, activate protein, cyclic nucleotides, calcium ions and other multi-path molecular signaling pathways in vivo to produce synergistic amplification of signal molecules; improve hematopoietic microbiota Environment, regulate endocrine, regulate the metabolic balance of osteoclasts and osteoblasts; reduce alkaline phosphatase, increase serum osteoprotegerin, osteocalcin and other bone metabolism marker indexes; increase bone density of femur, tibia, vertebra, and bone The reconstructed bone morphology and bone biomechanical marker indexes are significantly improved, which can effectively prevent and treat osteoporotic fractures, osteoarthritis and bone pain diseases.

Description

technical field [0001] The invention belongs to the technical field of research on the dosage, effect and function of the compatibility of natural medicine prescriptions, and in particular relates to a natural medicine composition for treating osteoporotic fractures and / or osteoarthritis and its application. Background technique [0002] Osteoporosis is a systemic metabolic bone disease characterized by low bone mass and destruction of bone microarchitecture, resulting in increased bone fragility and susceptibility to fracture. Osteoporotic fractures are the most serious consequence of osteoporosis. Fractures caused by osteoporosis are fragility fractures. Due to the decrease in bone strength, non-violent actions in daily life can cause fractures. Such fractures are complete fractures and have a high prevalence in the elderly. Common fracture sites are the thoracolumbar spine, proximal humerus, and distal radius, and the elderly are prone to multiple fractures in the hip an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A23L33/00A61P19/08A61P19/02
CPCA61K36/185A61P19/02A61P19/08A61K36/258A61K2300/00
Inventor 魏霞蓁宋兰兰韩少华
Owner ZHEJIANG INNOVATION WISDOM VALLEY TECH CO LTD
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