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Preparation method of licorice cream

A licorice frost and licorice technology are applied in the field of preparation of licorice frost, and can solve the problems of easy storage and deterioration, low glycyrrhizic acid purity, long extraction time, etc., reduce the risk of spoilage, reduce the risk of spoilage, the process is green and environmental protection, and is easy to industrialize production. Effect

Inactive Publication Date: 2017-01-25
EASTERN GANSU UNIVERSITY
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

These methods have their own advantages and disadvantages. For example, the water extraction method is simple to operate and low in cost. However, due to the long extraction time, glycyrrhizic acid is easily hydrolyzed by enzymes and the loss is relatively large, and the extraction rate is low (less than 50% of the active ingredients of licorice). On the contrary, water-soluble components such as proteins and sugars are easy to be extracted, resulting in low product purity and easy corruption and deterioration in storage; organic solvent extraction has a simple process and a relatively high extraction rate, but it is easy to cause environmental pollution and organic solvent residues in the product. Product quality; the extraction rate of glycyrrhizic acid extracted with dilute ammonia water is high, but ammonia gas is easy to leak during the extraction process, causing environmental pollution; Cause environmental pollution; although ultrasonic extraction and microwave extraction have the advantages of short extraction time and high extraction rate of active ingredients, they cannot significantly improve the extraction efficiency, and the sample processing volume is small, which is only suitable for a small amount of rapid extraction, and the product quality is relatively low. Moreover, the equipment is relatively expensive, which is easy to cause electromagnetic and acoustic pollution, and it is difficult to achieve large-scale production; enzymatic extraction has the advantages of high product safety, mild production conditions, low energy consumption, and no pollution, but the enzyme cannot be recycled after use, and the reaction requirements The pH value is finely controlled. Due to the complex composition of the cell wall, a single enzyme cannot be used to achieve a good extraction effect, and the price of the enzyme preparation is relatively expensive, making it difficult to achieve industrial production; supercritical CO 2 Extraction method, good selectivity, easy separation of products, high extraction rate, but small sample processing volume, need to add polar solvent and operate under high pressure during extraction, cumbersome operation process, difficult to control reaction conditions, high equipment investment, etc.
In addition, the main problem still existing in the production of domestic licorice cream is that only the content of glycyrrhizic acid is used as an indicator, and fat-soluble flavonoids that are more valuable than glycyrrhizic acid are ignored. A large number of licorice flavonoids are Left in the waste residue and discarded, on the one hand, it causes environmental pollution and a great waste of licorice resources; This has become a bottleneck for domestic licorice cream to enter the international market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 A kind of preparation method of licorice cream, comprises the following steps:

[0029] (1) Remove impurities and mildew from the raw licorice, rinse it with clean water, dry it at 20°C for 12 hours, and crush it through an 80-mesh sieve to obtain licorice powder.

[0030] (2) Add licorice powder and 60% ethanol aqueous solution at a solid-to-liquid ratio of 1:10 g / mL into a high-speed homogenizer at room temperature with a rotation speed of 10,000 r / min, an extraction time of 30 min, and extraction times The homogenate extraction was carried out under the condition of 2 times, and the extract and filter residue were obtained respectively; the extract was first recovered under reduced pressure at 20 °C and a vacuum of 0.05 MPa to recover ethanol, and then dried at 25 °C for 3 h to obtain the alcohol extract thing.

[0031] (3) After drying the filter residue at 35 °C for 5 h, add it into the ammonia solution with a volume concentration of 1.5% at a solid-t...

Embodiment 2

[0034] Embodiment 2 A kind of preparation method of licorice cream, comprises the following steps:

[0035] (1) Remove impurities and mildew from the raw licorice, rinse it with clean water, dry it at 25°C for 10 hours, and crush it through an 80-mesh sieve to obtain licorice powder.

[0036] (2) Add licorice powder and 85% ethanol aqueous solution at a solid-to-liquid ratio of 1:12 g / mL into a high-speed homogenizer at room temperature with a rotation speed of 8000 r / min, an extraction time of 40 min, and extraction times The homogenate extraction was carried out under the condition of 2 times, and the extract and filter residue were obtained respectively; the extract was first recovered under reduced pressure at 22 °C and a vacuum of 0.055 MPa to recover ethanol, and then dried at 23 °C for 4 h to obtain the alcohol extract things.

[0037] (3) After drying the filter residue at 40°C for 4.5 h, add it into the ammonia solution with a volume concentration of 2.0% at a solid-...

Embodiment 3

[0040] Embodiment 3 A kind of preparation method of licorice cream, comprises the following steps:

[0041] (1) The raw material licorice was removed from impurities and mildew, rinsed with clean water, dried at 23°C for 11 h, and crushed through an 80-mesh sieve to obtain licorice powder.

[0042] (2) Add licorice powder and 80% ethanol aqueous solution with a volume concentration of 1:8 g / mL to a high-speed homogenizer at a rotation speed of 9000 r / min, extraction time of 25 min, extraction times The homogenate extraction was carried out under the condition of 2 times, and the extract and filter residue were obtained respectively; the extract was first recovered ethanol under reduced pressure at 25 °C and a vacuum of 0.06 MPa, and then dried at 20 °C for 4 h to obtain the alcohol extract things.

[0043] (3) After drying the filter residue at 40 °C for 4 h, add it to the ammonia solution with a volume concentration of 1.8% at a solid-to-liquid ratio of 1:15 g / mL, and extrac...

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Abstract

The invention relates to a preparation method of licorice cream. The method comprises the following steps: (1) removing impurities and mildew of licorice which is used as a raw material, thoroughly washing the licorice with clear water, drying and crushing the licorice to obtain licorice powder; (2) adding the licorice powder and a 60%-95% alcohol aqueous solution into a high-speed homogenating machine for homogenating and extracting to obtain an extraction solution and filter residue, successively recycling alcohol from the extraction solution under reduced pressure and drying to obtain an alcohol extract; (3) drying the filter residue, adding the filter residue into a 1.0-2.0% ammonia aqueous solution, homogenating and extracting, and concentrating the filter residue under reduced pressure, then adjusting the pH value of a concentrated solution to 1.5-2.0 via a sulfuric acid solution, standing until precipitate is not increased, carrying out suction filtration and washing with water to obtain filter cake which is an aqueous extract; (4) mixing the alcohol extract with the aqueous extract, then carrying out ultrasonic dissolving in water, and carrying out ultra-filtration via a separation membrane to obtain dialyzate; and (5) carrying out spray drying on the dialyzate to obtain the licorice cream. The preparation method of the licorice cream is simple and convenient in operation process, green and environment-friendly in process, low in production cost and high in applicability, and is easy for industrial production.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicine preparations, in particular to a preparation method of licorice cream. Background technique [0002] Glycyrrhiza (Glycyrrhiza) is a plant with the same origin of medicine and food developed at home and abroad in recent years. It enjoys the reputation of "king of Chinese herbal medicine" because it is rich in various pharmacological active ingredients such as glycyrrhizic acid, glycyrrhetinic acid, flavonoids, polysaccharides and amino acids. , has the effects of invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasm and relieving pain, and harmonizing various medicines. Licorice cream is a fine powder made from licorice through processing, extraction, and spray drying. Its active ingredients are mainly glycyrrhizic acid and licorice flavonoids. In addition to its special sweet taste, g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484
CPCA61K36/484A61K2236/333A61K2236/53
Inventor 胡浩斌韩明虎王宗博
Owner EASTERN GANSU UNIVERSITY