Purifying method for rabeprazole sodium

A technology of rabeprazole sodium and a purification method, which is applied in the field of medicine, can solve the problems of high quality requirements for crude dex-rabeprazole sodium, poor concentration of dex-rabeprazole sodium, long reaction time and easy oxidation, etc. To achieve the effect of overcoming impurities that are easily brought in, reducing residual dissolution, and improving the effect of clinical medication

Inactive Publication Date: 2017-01-25
岳阳正昊化学科技有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the purification of dextro-rabeprazole sodium mainly has the following methods: direct dehydration under reduced pressure into a slurry, and then add ethers (including petroleum ether, diethyl ether, isopropyl ether, etc.) to separate out crystals to be purified. This method is not easy To remove impurities, the crude product of dex-rabeprazole sodium has high quality requirements, and the dehydration is not complete, and the crystals are fine and difficult to filter
[0006] Repeated extraction between the organic phase and the aqueous solution by using the difference in solubility at different pH values, then distilling off the organic solvent under reduced pressure, and recrystallizing in acetone for purification, this method can remove sulfone impurities very well, but The operation is cumbersome, and the solvent is highly toxic, and it is not easy to completely remove
[0007] After adding acetonitrile several times and concentrating under reduced pressure to take out water, add ethers (including petroleum ether, diethyl ether, isopropyl ether, etc.), acetone, methyl isobutyl ketone or ethyl acetate to precipitate dex-rabeprazole sodium , this method has a long reaction time and is easy to oxidize. At the same time, organic solvents such as acetone, methyl isobutyl ketone or ethyl acetate are more toxic and difficult to remove completely.
[0008] Therefore, in order to overcome the deficiencies in the purification and refining process of dex-rabeprazole sodium in the above-mentioned technology, and the disadvantages that the produced dex-rabeprazole sodium has a relatively poor degree, which easily leads to a sharp decline in the stability of the preparation, a simple and easy method is obtained by exploring The purification method of dextro-rabeprazole sodium

Method used

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  • Purifying method for rabeprazole sodium
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Examples

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Embodiment 1

[0033] A method for purifying dexrabeprazole sodium, comprising the following steps:

[0034] (1) the dextro-rabeprazole sodium crude product is dissolved in 25% ammonia water, and toluene solvent is added;

[0035] (2) adjusting the pH of the solution obtained in step (1) to 7.5 with 50% glacial acetic acid;

[0036] (3) adding step (2) gained solution to the activated carbon through special treatment, and the consumption is 20% of the dextro-rabeprazole sodium quality;

[0037] (4) the solution obtained in step (3) was stirred for 1 hour;

[0038] (5) the solution obtained in step (4) is filtered and layered;

[0039] (6) adding an appropriate amount of NaOH aqueous solution to the solution obtained in step (5) and stirring to form a salt, then filtering to obtain a pure product with a purity of 99.9% as detected by HPLC, the single impurity does not exceed 0.1%, and the total impurity does not exceed 0.5%.

Embodiment 2

[0041] A method for purifying dexrabeprazole sodium, comprising the following steps:

[0042] (1) dextro-rabeprazole sodium crude product is dissolved in 12.5% ​​ammonia water, and toluene solvent is added;

[0043] (2) adjusting the pH of the solution obtained in step (1) to 8.5 with 50% glacial acetic acid;

[0044] (3) adding step (2) gained solution to the activated carbon through special treatment, and the consumption is 25% of the dextro-rabeprazole sodium quality;

[0045] (4) the solution obtained in step (3) was stirred for 1.5 hours;

[0046] (5) the solution obtained in step (4) is filtered and layered;

[0047] (6) The solution obtained in step (5) is added with an appropriate amount of NaOH aqueous solution, stirred into a salt, and filtered to obtain a pure product. The purity detected by HPLC is 99.8%. .

Embodiment 3

[0049] A method for purifying dexrabeprazole sodium, comprising the following steps:

[0050] (1) dextro-rabeprazole sodium crude product is dissolved in 12.5% ​​ammonia water, and toluene solvent is added;

[0051] (2) adjusting the pH of the solution obtained in step (1) to 7.5 with 50% glacial acetic acid;

[0052] (3) adding step (2) gained solution to the activated carbon through special treatment, and the consumption is 25% of the dextro-rabeprazole sodium quality;

[0053] (4) the solution obtained in step (3) was stirred for 1 hour;

[0054] (5) the solution obtained in step (4) is filtered and layered;

[0055] (6) adding an appropriate amount of NaOH aqueous solution to the solution obtained in step (5) and stirring to form a salt, then filtering to obtain a pure product with a purity of 99.9% as detected by HPLC, the single impurity does not exceed 0.1%, and the total impurity does not exceed 0.5%.

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Abstract

The invention discloses a purifying method for rabeprazole sodium. The method comprises the following steps: dissolving a crude product of rabeprazole sodium in aqueous alkali; adding methylbenzene; under the nitrogen protection, regulating pH value to 7.0-8.0; adding an adsorbent and then filtering; separating the organic phase and then adding sodium hydroxide aqueous solution and filtering; collecting solid, thereby acquiring a purified product of rabeprazole sodium. Compared with the present purifying method, the method provided by the invention has advantages; the crude product of rabeprazole sodium is unstable in the process of crystallizing in the solution or dewatering and is easy to degrade or decompose, so that the impurities are increased and the purity is reduced; an experiment proves that the pH value regulation before salt forming and the active carbon decoloration method for refining can greatly reduce the degradation and decomposition of the products; the product can meet the qualified requirement, without re-crystallizing after the salt forming; the re-crystallizing after the salt forming is not required, so that the dosage of the organic solvent can be effectively reduced, the yield can be increased and the residual solvent content also can be reduced.

Description

technical field [0001] The invention relates to a purification method of dextro-rabeprazole sodium, which belongs to the technical field of medicine. Background technique [0002] Dex-rabeprazole sodium, chemical name: 5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl Acyl]-1H-benzimidazole sodium, molecular formula: C18H20N3O3SNa, molecular weight: 381.1, structural formula is as follows: [0003] [0004] Proton pump inhibitors (PPIs) are the drugs of choice for the treatment of acid-related diseases such as peptic ulcers and gastroesophageal reflux disease. At present, there are five PPIs commonly used in clinical practice: omeprazole, lansoprazole, rabeprazole, pantoprazole and esomeprazole. Dex-rabeprazole sodium is a single isomer of rabeprazole sodium, the (R)-isomer. Due to its metabolic advantage, d-rabeprazole sodium has higher bioavailability and more consistent pharmacokinetics, resulting in increased drug arrival at the proton pump and be...

Claims

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Application Information

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IPC IPC(8): C07D401/12
CPCC07D401/12
Inventor 李光黄正良杨小平
Owner 岳阳正昊化学科技有限公司
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