Method for preparing porous implant through gelcasting 3D printing and electroreduction

Abstract

The invention discloses a method for preparing a porous implant through gelcasting 3D printing and electroreduction. The preparation method comprises steps as follows: according to the human body features of a to-be-implanted part, a personalized gradient porous implant negative-type mold adopting a microstructure is designed by the aid of a medical image data reverse solution model; a gradient porous implant negative-type resin mold is prepared through photo-curing forming equipment; metal oxide ceramic slurry is injected into the negative-type resin mold through a gel injection mold and sintered at the high temperature, and a metal oxide ceramic porous scaffold is obtained; a primary porous metal implant is produced through molten salt in-situ reduction; a metal coating is deposited on the surface of the primary porous metal implant with a chemical vapor deposition method. The defects that implants with complex shapes, precise sizes and uncontrollable microstructures cannot be produced with a traditional porous implant preparation method are overcome, structure nanosizing can be realized, and a new way for preparing the porous implant is expected to be developed.

Description

Technical field [0001] The invention relates to a method for preparing porous implants by gel injection molding 3D printing and electrolytic reduction. The method belongs to the field of biological additive manufacturing (3D printing) and can be applied to the field of biomedicine. Background technique [0002] Additive manufacturing has important applications in the medical field, especially for the manufacture of personalized implants, which has unparalleled advantages, and has a potential market of tens of billions in the future. At present, implants manufactured by direct metal forming of stainless steel, titanium alloy and cobalt-based alloys have been widely used in heart valve stents, blood vessel stents, digestive tract stents, bone repair and replacement stents and other stents. A better treatment effect. However, the complex human body environment can cause material corrosion and lead to the release of toxic elements, which leads to the reduction of the biocompatibilit...

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the uncontrollable microscopic gradient structure of porous implant scaffolds and the inability to form nanostructures, the object of the present invention is to provide a method for preparing porous implants by gel injection molding 3D printing and electrolytic reduction. The combination of forming, gel injection molding, molten salt electrolytic reduction technology and chemical vapor deposition technology can realize the controllable forming of microscopic gradient structure, and forming nanostructures is conducive to cell activities, improving the biocompatibility of porous implants, which is expected Opening up a new way to prepare porous scaffolds is of great significance for promoting the clinical application of porous implants