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Degradable starch hemostatic sponge and preparation method thereof

A technology for hemostatic sponge and starch degradation, applied in the field of medical sponge, can solve the problems of unsuitability for industrial production, long time required for healing, unsatisfactory hemostatic effect, etc., and achieves good market prospects, simple production and various effects.

Inactive Publication Date: 2017-03-08
SHANDONG MEITAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Starch hemostatic sponge can directly act on bloody wounds, has good biocompatibility, and avoids potential risks such as allergies and infections caused by the use of animal-derived collagen and other materials, but the hemostatic effect of existing hemostatic sponges is not ideal. Slow, takes a long time to heal, and the preparation method is complicated, so it is not suitable for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Weigh 64g of starch, 0.064g of sodium trimetaphosphate, and 100ml of sodium hydroxide solution with a pH of 10, and react for 4 hours at 40°C. After the reaction, centrifuge, wash, dehydrate with ethanol, and dry;

[0025] (2) Weigh 20g of the product obtained in step (1), 2.0g of sodium hydroxide, 50ml of water, 300ml of ethanol, stir at 25°C for 2 hours, add sodium chloroacetate solution (sodium chloroacetate: water: ethanol = 1:10 : 10) 88ml, heated up to 40°C and continued to react for 2 hours. After the reaction, adjust the pH value to neutral, wash, dehydrate with ethanol, and dry;

[0026] (3) Weigh 1g of the product obtained in step (2), 0.01g of gallic acid, 0.1g of polyethylene glycol (PEG-4000), 30ml of water, stir until completely dissolved, pour into a silica gel mold and place in a freeze dryer , the pre-freezing temperature of the lyophilizer was set at -60°C, the pre-freezing time was set at 4 hours, and the freeze-drying time was 43 hours.

Embodiment 2

[0028] (1) Take by weighing 64g of starch, 2.0g of sodium trimetaphosphate, 100ml of sodium hydroxide solution with a pH of 12, and stir for 5 hours at 45°C. After the reaction is over, centrifuge, wash, dehydrate with ethanol, and dry;

[0029] (2) Weigh 20 g of the product obtained in step (1), 4.0 g of sodium hydroxide, 40 ml of water, and 240 ml of ethanol, and react at 30° C. for 3 hours. Add 68 ml of sodium chloroacetate solution (sodium chloroacetate: water: ethanol = 1: 10:: 10), raise the temperature to 50°C and continue the reaction for 3 hours. After the reaction, adjust the pH value to neutral, wash, dehydrate with ethanol, and dry;

[0030] (3) Weigh 1g of the product obtained in step (2), 0.05g of gallic acid, 0.06g of polyethylene glycol (PEG-4000), 30ml of water, stir until completely dissolved, pour it into a silica gel mold and put it in a freeze dryer , The pre-freezing temperature of the lyophilizer is set at -40°C, the pre-freezing time is set at 12 hours...

Embodiment 3

[0032] (1) Take by weighing 64g of starch, 3.2g of sodium trimetaphosphate, and 100ml of sodium hydroxide solution with a pH of 14, and stir for 6 hours at 50°C. After the reaction, centrifuge, wash, dehydrate with ethanol, and dry;

[0033] (2) Weigh 20 g of the product obtained in step (1), 10 g of sodium hydroxide, 65 ml of water, 390 ml of ethanol, and react at 40° C. for 4 hours. Add 72 ml of chloroacetic acid solution (chloroacetic acid: water: ethanol = 1: 10: 10), raise the temperature to 60°C and continue the reaction for 5 hours. After the reaction, adjust the pH value to neutral, wash, dehydrate with ethanol, and dry;

[0034] (3) Weigh 1g of the product obtained in step (2), 0.1g of gallic acid, 0.01g of polyethylene glycol (PEG-4000), 30ml of water, stir until completely dissolved, pour into a silica gel mold and place in a freeze dryer , The pre-freezing temperature of the lyophilizer is set at -20°C, the pre-freezing time is set at 24 hours, and the freeze-dryi...

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PUM

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Abstract

The invention belongs to the field of medical sponge, and in particular relates to degradable starch hemostatic sponge and a preparation method of the degradable starch hemostatic sponge. According to the preparation method of the degradable starch hemostatic sponge, natural plant starch is subjected to the modification treatment including crosslinking and substitution, the modified natural plant starch is subjected to compound dissolving in polyethylene glycol and gallic acid, the product after compound dissolving is subjected to freeze-drying, and thus the degradable starch hemostatic sponge is obtained. The interior of the degradable starch hemostatic sponge has the loose structure with rich pore passages, therefore, the degradable starch hemostatic sponge has very good water absorption, after the sponge absorbs plasma in the blood, gel can be rapidly formed, so that the injured tissue and blood vessel can be effectively blocked, meanwhile, the blood concentration can be improved, the platelet aggregation can be accelerated, and the bleeding stopping operation can be promoted. After the bleeding stopping operation is completed, the degradable starch hemostatic sponge can be degraded to be absorbed by the human body or directly cleaned by adopting normal saline or pure water, no residue is caused, the wound surface is not damaged, the preparation method is simple and rapid, the yield is high, the cost is low, no pollution is caused to the environment, the reaction conditions are mild, the quality is stable, and the preparation method is suitable for industrialization.

Description

technical field [0001] The invention belongs to the field of medical sponges, and in particular relates to a degradable starch hemostatic sponge and a preparation method thereof. Background technique [0002] Surgical operations and trauma will form bloody wounds, during which a large amount of blood will flow out, and effective hemostasis methods need to be taken in time. Among them, the commonly used means of hemostasis is to apply a biocompatible absorbable hemostatic material on the bleeding wound, and the hemostatic sponge is one of them. Existing commonly used surgical absorbable hemostatic sponges include: gelatin sponges, collagen sponges, chitosan hemostatic sponges, and sponges containing thrombin or fibrin. Gelatin sponge and collagen sponge concentrate the blood by absorbing water in the blood to achieve a hemostatic effect. Gelatin sponge and collagen sponge are absorbed slowly by the human body, and are derived from animal collagen extracts, which can easily ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/42
Inventor 王瑛纪晨旭王绪帅刘娜朱连连
Owner SHANDONG MEITAI PHARMA CO LTD