Preparation method of phenacetin micropowder

Abstract

The invention discloses a preparation method of phenacetin micropowder. The preparation method comprises steps as follows: (1) ethanol is added to a raw material of phenacetin, and the solution is heated to 50-78 DEG C, kept at the constant temperature and stirred to be dissolved; (2) the stirring rate is controlled between 250 rpm and 350 rpm, the phenacetin ethanol solution is added to purified water at 25-40 DEG C while hot; (3) after addition, the solution is continuously stirred for 30 min, then cooled to 15-30 DEG C and stirred for crystallization for 2-4 h, and the phenacetin micropowder is obtained after filtering and drying. Compared with the prior art, the preparation method has the advantages as follows: 1) the micropowder is uniform in particle and smaller in particle size, and 95% or higher of the micropowder has the particle size of 120 meshes or below; 2) the dissolution rate of the micropowder is obviously increased, the dissolution rate of phenacetin is remarkable increased, and the bioavailability of phenacetin is improved; 3) the preparation method is high in yield, adopts a mild condition, a simple production technology and an easily controllable process and is safe to operate, low in cost and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and relates to a preparation method of phenacetin micropowder. Background technique [0002] Phenacetin, the chemical name is p-acetaminophenethyl ether, the molecular formula is C 10 h 13 NO 2 . Phenacetin is a common bulk antipyretic and analgesic. It was first synthesized by Morse in 1878 and listed in the United States in 1887. It is the first synthetic antipyretic and analgesic on the market. It is often used to treat headaches, Fever, neuralgia, etc. Phenacetin is the main component of compound preparations such as Qutong Tablets and compound aspirin, which are used for antipyretic and analgesic, and to treat colds and colds. The antipyretic effect of phenacetin is stronger than the analgesic effect. The potency is comparable to that of aspirin, with slow and long-lasting action and low toxicity. It has good curative effect on treating headache, neuralgia, arth...

AI Technical Summary

Problems solved by technology

[0004] Although jet milling and ball milling are commonly used methods to reduce the particle size of drugs, they generally have disadvantages such as high energy consumption, low efficiency, wide product particle size distribution, and easy structural damage and degradation of thermally unstable drugs. Will cause problems such as dust pollution and static electricity safety

Although spray drying and supercritical fluid technology can produce micronized drugs with narrow particle size distribution, the cost of equipment is high

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