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Method for preparing 2-carbonyl ethyl butyrate salicylhydrazone nickel complex and application of 2-carbonyl ethyl butyrate salicylhydrazone nickel complex

A technology of ethyl carbonyl butyrate salicyloyl hydrazone and ethyl carbonyl butyrate salicyloyl hydrazone, applied in the directions of botanical equipment and methods, nickel organic compounds, applications, etc., to achieve easy industrial production, high sterilization efficiency, and simple synthesis method. Effect

Inactive Publication Date: 2017-03-08
NORTHWEST UNIV(CN)
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And in a large amount of hydrazone compounds with biological activity, the metabolites of aroyl hydrazones are all low-toxic or non-toxic, and so far there is no information about the nickel complex of ethyl 2-carbonylbutyrate salicylhydrazone and its role as an inhibitor of rice blast. and other crop diseases reported in the literature

Method used

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  • Method for preparing 2-carbonyl ethyl butyrate salicylhydrazone nickel complex and application of 2-carbonyl ethyl butyrate salicylhydrazone nickel complex
  • Method for preparing 2-carbonyl ethyl butyrate salicylhydrazone nickel complex and application of 2-carbonyl ethyl butyrate salicylhydrazone nickel complex
  • Method for preparing 2-carbonyl ethyl butyrate salicylhydrazone nickel complex and application of 2-carbonyl ethyl butyrate salicylhydrazone nickel complex

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preparation example Construction

[0031] The preparation method of ethyl 2-carbonyl butyrate salicylhydrazone nickel complex is characterized in that it comprises the following steps:

[0032] Step a, the preparation of salicylhydrazide;

[0033] Add methyl salicylate and hydrazine hydrate to absolute ethanol at a material ratio of 1:1.1, heat and back-distill to react, evaporate most of the ethanol, cool, stir, and precipitate a white solid, recrystallize with a mixed solvent of water and ethanol , to obtain white needle-like crystals;

[0034] Step b, the preparation of ethyl 2-oxobutyrate salicylhydrazone;

[0035] Add salicylic hydrazide and ethyl acetoacetate into 40mL of absolute ethanol at a material ratio of 1:2, heat and stir in a water bath for back distillation, and react after cooling, white needle-like crystals are precipitated, and the crude product obtained by suction filtration is washed with anhydrous Recrystallized from ethanol to obtain white needle-like crystals;

[0036] Step c, prepara...

Embodiment 1

[0048] Example 1 Field efficacy experiment of ethyl 2-carbonylbutyrate salicyloylhydrazone nickel complex on rice blast

[0049] Experimental principle: The growth rate method is also called the medium dosing method. The method is to mix the test agent with the unsolidified culture medium evenly, and then inoculate the bacteria after cooling and solidification, and use this drug-containing medium to cultivate the bacteria, and judge the inhibitory effect of the test agent by the speed of mycelium growth. bacteria effect.

[0050] The test agent: 2-carbonyl butyrate ethyl salicylhydrazone nickel complex (NiL)

[0051] Pathogen tested: rice blast pathogenic fungus

[0052] Experimental steps: preparation of test agents with different concentration gradients, preparation of pathogenic bacteria, preparation of medium for test agents

[0053] Fight pathogenic bacteria, inoculate, cultivate, inspect

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Abstract

The invention relates to a method for preparing a 2-carbonyl ethyl butyrate salicylhydrazone nickel complex and an application of the 2-carbonyl ethyl butyrate salicylhydrazone nickel complex. The compound is a complex of 2-carbonyl ethyl butyrate salicylhydrazone and nickel. A synthesis method comprises the step of subjecting methyl salicylate, hydrazine hydrate, ethyl acetoacetate and nickel nitrate, which serve as raw materials, to a reaction for 3 hours in an ethanol solution at the temperature of 80 DEG C, thereby preparing the target product. The 2-carbonyl ethyl butyrate salicylhydrazone nickel complex prepared by the method has an obvious effect on the resistance and treatment of wheat rust, rice blast, apple rot and tomato gray mold, the fungicidal efficiency is high, and the preparation method is simple.

Description

technical field [0001] The invention relates to the technical field of fungicides, in particular to the preparation of a nickel complex of ethyl 2-carbonylbutyrate salicylhydrazone and its application as a novel fungicide for rice blast. Background technique [0002] Due to the excellent biological activity of hydrazones, especially the effective inhibitory effect on many enzymes, they are widely used in pesticides, medicines and analytical reagents. For example, hydrazone is used to control rice Bacteria such as helminthiasis and rice pear spores. Such hydrazone compounds have made significant contributions to the development of catalysts, enzyme reactions, molecular structures, and materials chemistry. Since hydrazone metal complexes have better biological activity than hydrazones themselves, it is meaningful to develop new hydrazone metal complexes as fungicides. [0003] Rice blast is one of the most harmful diseases of rice. Sheath blight and bacterial blight are list...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/04A01N37/40A01N55/02A01P3/00
CPCC07F15/045A01N37/40A01N55/02
Inventor 李卓崔国意马晓迅李恒欣
Owner NORTHWEST UNIV(CN)