Lamiophlomis rotata(Benth.) Kudo solid dispersion preparation and preparation method thereof

A solid dispersion, unique technology, applied in the field of medicine, can solve the problems of large dosage, difficult storage of granules, low dissolution rate of preparations, etc. The effect of industrial production

Inactive Publication Date: 2017-03-22
GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of the existing granule preparations are clear at a glance. The oral dosage is large each time, and it needs to be dissolved with boiling water before taking it. Moreover, the medicine itself has a strong bitter taste. Inconvenience, etc. can easily lead to

Method used

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  • Lamiophlomis rotata(Benth.) Kudo solid dispersion preparation and preparation method thereof
  • Lamiophlomis rotata(Benth.) Kudo solid dispersion preparation and preparation method thereof
  • Lamiophlomis rotata(Benth.) Kudo solid dispersion preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: the preparation of unique tablet

[0058] (1) Take 800g of Duyiwei, add 3 times the amount of 80% ethanol to soak overnight, reflux extraction for 2 hours, filter to obtain the extract, the filtrate recovers ethanol and concentrates to an extract with a relative density of about 1.20, and vacuum-dries to make a dry extract Yantuo extract extract powder, add 5 times water to the dregs, boil again for 2 hours, filter, concentrate the filtrate, dry and pulverize, combine twice to extract the powder, and set aside;

[0059] (2) Set the control temperature of the Haake micro-mixing rheometer to 110°C, the screw speed to 30r / min, and the torque to 20N.cm; place 200g of the drug carrier material Soluplus with the unique extract powder prepared in step 1) In the hopper, the material is extruded in the shape of strips from the die hole of the machine head after being extruded, cooled at room temperature, crushed, and passed through an 80-mesh sieve to obtain a soli...

Embodiment 2

[0061] Embodiment 2: the preparation of unique soft capsule

[0062] (1) Take 1000g of Duyiwei, add 3 times the amount of 80% ethanol to soak overnight, reflux extraction for 2 hours, filter to obtain the extract, recycle the ethanol from the filtrate and concentrate it to an extract with a relative density of about 1.20, and vacuum dry it to make a dry extract Yantuo extract extract powder, add 5 times water to the dregs, boil again for 2 hours, filter, concentrate the filtrate, dry and pulverize, combine twice to extract the powder, and set aside;

[0063] (2) Set the control temperature of the Haake micro-mixing rheometer to 110°C, the screw speed to 30r / min, and the torque to 20N.cm; put 300g of the drug carrier material Soluplus with the unique extract powder prepared in step 1) In the hopper, the material is extruded in the shape of strips from the die hole of the machine head after being extruded, cooled at room temperature, crushed, and passed through an 80-mesh sieve ...

Embodiment 3

[0065] Embodiment 3: the preparation of unique soft capsule

[0066] (1) Take 1200g of Duyiwei, add 3 times the amount of 80% ethanol to soak overnight, reflux extraction for 2 hours, filter to obtain the extract, the filtrate recovers ethanol and concentrates to an extract with a relative density of about 1.20, and vacuum-dries to make a dry extract Yantuo extract extract powder, add 5 times water to the dregs, boil again for 2 hours, filter, concentrate the filtrate, dry and pulverize, combine twice to extract the powder, and set aside;

[0067] (2) Set the control temperature of the Haake micro-mixing rheometer to 110°C, the screw speed to 30r / min, and the torque to 20N.cm; place 400g of the drug carrier material Soluplus with the unique extract powder prepared in step 1) In the hopper, the material is extruded in the shape of strips from the die hole of the machine head after being extruded, cooled at room temperature, crushed, and passed through an 80-mesh sieve to obtain...

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Abstract

The invention provides a Lamiophlomis rotata(Benth.) Kudo preparation and a preparation method thereof. A Lamiophlomis rotata(Benth.) Kudo extract is prepared into a solid dispersion through a hot-melt extrusion technology, the dispersity and specific surface area are increased, leaching of effective components is promoted, the hydrophilicity of medicine is increased, the solubility and dissolving-out speed of the Lamiophlomis rotata(Benth.) Kudo solid dispersion are increased, the bioavailability of the medicine is improved, and medicine curative effect exerting is promoted.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of medicine, and in particular relates to a unique solid dispersion preparation and a preparation method thereof. [0003] technical background: [0004] Duyiwei is a folk herbal medicine of Tibetan, Mongolian, Naxi and other ethnic groups, and it is the whole herb of Lamiophlomis Rotata (Benth.) Kudo, a plant of the Labiatae family. It was first recorded in the famous Tibetan medical works "Four Medical Codes" and "Yuewang Medicine Diagnosis". Modern pharmacological studies have shown that Duyiwei has hemostatic, analgesic, antibacterial, acute, and anti-tumor effects, has low toxicity, few side effects, and can also improve specific and non-specific immune functions. [0005] Duyiwei's current marketed dosage forms are tablets, capsules, granules, and soft capsules; it can relieve pain and stop bleeding. It is prepared by adding appropriate amount of excipients after extracting unique herbs with w...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/48A61K9/00A61K36/53A61K47/32
Inventor 郎洪平
Owner GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
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