Design and application of novel diabetes immunomodulatory peptide-vp peptide
A technology for immune regulation and diabetes, which is applied in the fields of pharmacy and medicine, can solve problems such as vascular endothelial cell damage, achieve the effects of reducing the level of insulitis, controlling blood sugar levels, and maintaining normal secretion function
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Embodiment 1
[0026] Example 1: Evaluation of side effects of VP peptide atherosclerosis
[0027] 1. Breeding and immunization of New Zealand white rabbits
[0028] New Zealand white rabbits were divided into two groups according to different feeding conditions, 24 in the low-fat group (LCD) and 24 in the high-fat group (HCD). The low-fat group was always fed with common feed, and the high-fat group was fed with high-fat feed until the end of the experiment. The formula of high-fat feed is to add 1% cholesterol, 6% lard and 10% egg yolk powder on the basis of ordinary rabbit feed. The two groups were divided into four groups: PBS group, P277 group, VP group and AP group, with 6 rats in each group. Animals in each group were immunized for the first time from the zeroth week, and were immunized four times in total, with an interval of 4 weeks between the two times. Dissolve P277 / VP / AP in sterile PBS at a concentration of 1 mg / mL. CFA was used as an adjuvant for the first immunization, and ...
Embodiment 2
[0034] Example 2: Evaluation of diabetes-related pharmacodynamics of VP peptide
[0035] 1. Animal immunity
[0036] Twenty-five 4-week-old female NOD / LtJ mice were randomly divided into 4 groups, AP group, VP group, P277 group (positive control) and oil group (blank control). From the 5th week of NOD, the drug was administered subcutaneously in the neck every two weeks, for a total of 3 times, respectively at the 5th, 7th, and 9th week. Before administration, the polypeptide was dissolved in Libaofatine at 1 mg / mL, and the dosage was 80 μg / head.
[0037] 2. Effects on body weight and blood sugar of NOD mice
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