The invention discloses a method for recycling
naproxen resolution
solvent, resolving agent and by-product by the overgravitational field. A solution containing a resolution
solvent, a resolving agent such as N-n-octylglucamine, and by-product such as L-
naproxen and L-
naproxen N-n-octylglucamine salt after the separation of D- naproxen N-n-octylglucamine salt is firstly added in a overgravitational revolving
bed for recycling resolution
solvent, then the residual solution is diluted by water, the pH value is adjusted to 7 to 12, the resolving agent is recycled, the
mother liquor is concentrated, the alkali C is added, the D,L- naproxen salt is obtained by the
racemization reaction. The method adopts the overgravitational revolving
bed to recycle the resolution solvent, the process is simple, the whole process is safe, steady and reliable, the operation and the maintenance are simple, the runing cost is greatly reduced, at the same time the production efficiency is improved; the obtained
methanol is uniform, the
recovery rate of the resolving agent and the D,L- naproxen salt is high, the obtained resolution solvent, resolving agent and D,L- naproxen salt can be directly reused, thus being resource-saving and having obvious environment benefit and social benefit.