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Calcium oral cavity rapid-dissolving membrane agent and preparation method thereof

An oral instant film and calcium source technology, applied in the fields of medicine, health care, and food, can solve the problems of low efficacy and utilization rate of calcium tablets, existence of first pass effect, and unsatisfactory absorption rate, and achieve good palatability and onset of effect. Fast, palatable effect

Inactive Publication Date: 2017-04-26
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The commonly used oral preparations on the market are mostly tablets, capsules, and pills, all of which need to be chewed or swallowed into the digestive tract to be absorbed before they can take effect. However, due to the low efficacy and utilization rate of calcium tablets, the absorption rate of our body is not ideal. And there is a first-pass effect in the swallowing process, which will bring a lot of trouble to patients with dysphagia

Method used

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  • Calcium oral cavity rapid-dissolving membrane agent and preparation method thereof
  • Calcium oral cavity rapid-dissolving membrane agent and preparation method thereof
  • Calcium oral cavity rapid-dissolving membrane agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The prescription quantity is 1000 tablets (each tablet contains 10mg of calcium citrate)

[0066]

[0067] Freeze-drying method: Weigh each component according to the formula, add 500g of water to dissolve, stir while adding, after stirring evenly, degas, apply the above-mentioned calcium citrate suspension on the plate evenly, and place it for freeze-drying In the machine for 30 minutes, cut (2cm×2cm) to obtain calcium oral instant film.

[0068] The film has good flexibility, melts and disperses quickly at the entrance, has a good taste and sweet taste, and the melting time in water at 37°C is 30s.

Embodiment 2

[0070] The prescription quantity is 1000 tablets (calcium lactate content per tablet is 6mg)

[0071]

[0072] Solvent casting method: according to the recipe, take the film-forming material polyvinyl alcohol and dissolve it in 500g of water to make a uniform viscous liquid. Under the action of a high-speed mixer, disperse other ingredients evenly in a small amount of water, then add to the above viscous liquid to form a uniform viscous liquid, and then vacuumize. The forming solution was coated on the casting film, dried and cut.

[0073] The film has good flexibility, melts and disperses quickly at the entrance, has a good taste and sweet taste, and the melting time in water at 37°C is 15s to 20s.

Embodiment 3

[0075] The prescription quantity is 1000 tablets (each chelated calcium content is 20mg)

[0076]

[0077] Hot-melt extrusion method: Weigh each component according to the formula and add it from the hopper to the feeding area of ​​the single-screw or twin-screw extruder, and send it into the hot-melt area to melt and mix well. The molten mixture is continuously output through the batching area. Put on film, cool, and cut.

[0078] The film has good flexibility, melts and disperses quickly at the entrance, has a good taste and sweet taste, and the melting time in water at 37°C is 15s to 20s.

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Abstract

The present invention relates to the technical field of medicine, health care, and food, particularly to a calcium oral cavity rapid-dissolving membrane agent and a preparation method thereof. According to the present invention, the calcium oral cavity rapid-dissolving membrane agent comprises a calcium source, vitamin D, a membrane material, a disintegrating agent, a filler, a plasticizer a flavoring agent, has characteristics of a certain flexibility and easy taking, does not produce discomfort during the taking, can be simply dissolved or disintegrated in the oral cavity, enters the digestive tract along with the swallowing action so as to be absorbed, has high solubility, and rapidly provide the effect, wherein the dissolving time of the calcium oral cavity rapid-dissolving membrane agent in 37 DEG C water is within 30 s; and the calcium oral cavity rapid-dissolving membrane agent further has pleasant taste and good palatability, can be taken without water, and is especially for children, elderly, and patients having swallowing difficulty.

Description

technical field [0001] The invention relates to the technical fields of medicine, health care and food, in particular to a calcium oral instant film and a preparation method thereof. Background technique [0002] The oral instant film preparation was launched in North America as early as 2003. The preparation has the characteristics of small size, high solubility, fast onset of action, and easy to grasp the accurate dosage of the users, especially children. It has been widely used in the international pharmaceutical market. Such as ondansetron fast-dissolving film (Zuplenz) developed by Strative Pharmaceuticals, diphenhydramine film (Triaminic Strips Cough & Runny Nose) listed by Novartis, and dextromethorphan film (Theraflu Thin Strip). The oral instant film preparation of the present invention refers to a film preparation processed by uniformly dispersing a certain dose of active ingredients in a film-forming material. The drug film is very flexible. When in use, the drug...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K9/70A61K47/38A61K47/32A61P3/14A61P3/02A61K31/59
CPCA61K9/006A61K9/7007A61K31/59A61K33/06A61K47/32A61K47/38A61K2300/00
Inventor 曾银杰钟文锋何燕陈炽豪钟振鹏陈泽丰武文敬程书朋江森龙威张焜郑希
Owner GUANGDONG UNIV OF TECH
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