Traditional Chinese medicinal compound gel emplastrum, and preparation method and use thereof

A compound and gel technology, which is applied in pharmaceutical formulas, non-central analgesics, antipyretics, etc., can solve problems such as poor taste of sprays and aerosols, heavy bitterness of oral liquids, and low bioavailability, achieving Reduce dosage, high content of active ingredients, overcome the effect of oral administration

Active Publication Date: 2017-04-26
杭州禾橼医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The new dosage form of the present invention is the result of continuous improvement and improvement on the basis of existing research. The administration routes of several dosage forms disclosed in Chinese patent 200810061131.5 are all oral administration, and there are many differences in compliance and therapeutic...

Method used

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  • Traditional Chinese medicinal compound gel emplastrum, and preparation method and use thereof
  • Traditional Chinese medicinal compound gel emplastrum, and preparation method and use thereof
  • Traditional Chinese medicinal compound gel emplastrum, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] (1) Raw material extraction:

[0077] Angelica 100g, Fritillaria 100g, Sophora flavescens 100g, crushed and passed through a 10-mesh sieve, refluxed with 1000ml acetone to extract twice, each time for 1hr, after combining the extracts, recover the acetone under reduced pressure to obtain 40g of extract;

[0078] (2) Preparation method:

[0079] 1) Add 0.3 g of aluminum hydroxide, 0.5 g of calcium carbonate, 15 g of povidone and the extract to 95 g of glycerin to dissolve in turn, stir well, then add 20 g of sodium polyacrylate and continue mixing. Stir well;

[0080] 2) Add 10 g of azone and 10 g of propylene glycol respectively, and stir evenly;

[0081] 3) Dissolve 1.8 g of tartaric acid and 1 ml of hydrochloric acid in water, add to the glycerin solution, add 0.33 g of EDTA, and continue to stir evenly;

[0082] 4) Coating, covering with a protective film, cutting into 100 pieces, drying and curing at room temperature, and packaging to obtain the gel plaster.

[...

Embodiment 2

[0085] (1) Raw material extraction:

[0086] Angelica 10g, Fritillaria 10g, Sophora flavescens 30g, crushed and passed through a 20-mesh sieve, refluxed with 320ml ethyl acetate to extract twice, each time for 1hr, combined the extracts and recovered ethyl acetate under reduced pressure to obtain 8.1g of extract;

[0087] (2) Preparation method:

[0088] 1) Disperse 15g NP-700, 4g aluminum glycolate, 1.2g zinc oxide, and 8.1g drug in 100ml glycerin, and mix well as the glycerin phase for later use;

[0089] 2) Add 10g of Carbomer 980, 10g of eucalyptus oil and 5g of isopropyl myristate to 30ml of propylene glycol, stir well and use as the propylene glycol phase for later use;

[0090] 3) Another 2.5g of citric acid, 1.5ml of phosphoric acid and 0.2g of EDTA were dissolved in an appropriate amount of pure water, and stirred evenly to obtain a mixed water phase for later use;

[0091] 4) First mix the water phase and the propylene glycol phase evenly, then add them to the glyc...

Embodiment 3

[0095] (1) Raw material extraction:

[0096] Angelica 400g, Fritillaria 100g, Sophora flavescens 400g, respectively crushed and passed through a 30-mesh sieve, combined with Fritillaria flavescens and Sophora flavescens, extracted twice with 2500ml ethyl formate, 1hr each time, combined the extracts and recovered ethyl formate under reduced pressure 75g of extract was obtained from the ester; Angelica sinensis was extracted by repeated percolation with 2000ml petroleum ether, 16.8g of extract was obtained after recovering petroleum ether under reduced pressure, and the extract of Angelica sinensis was mixed with hydroxypropyl β-cyclodextrin at room temperature to obtain 135g clathrate;

[0097] (2) Preparation method:

[0098] 1) Add medicinal extract, volatile oil inclusion compound, 1g polyvinylpyrrolidone (PVP K-90) and 3g carbomer 940 into 280ml water and stir evenly, as phase A for later use;

[0099] 2) Dissolve 4.8g of aluminum trichloride and 7.5ml of acetic acid in ...

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Abstract

The invention discloses a traditional Chinese medicinal compound gel emplastrum, and a preparation method and a use thereof. The traditional Chinese medicinal compound gel emplastrum comprises a backing layer, an emplastrum layer and a protection layer, wherein the emplastrum layer comprises a medicine and a matrix, the matrix comprises a skeleton component, an adhesive, a filler, a humectant, a pH regulator, a cross-linking agent, a cross-linking regulator, a transdermal enhancer and water, the medicine is extract of medicinal materials, and the medicinal materials comprise, by weight, 1-10 parts of Chinese angelica root, 1-10 parts of Bulbus Fritillaria and 1-10 parts of Sophora flavescens. The invention also discloses the preparation method and the use of the traditional Chinese medicinal compound gel emplastrum. The traditional Chinese medicinal compound gel emplastrum is externally applied to the specific acupoint of a human body, and effectively treats various respiratory system diseases comprising various acute and chronic bronchitis, chronic obstructive pulmonary diseases and upper respiratory infection. Compared with general oral medicines and injections, the emplastrum provides a novel external medicine having substantial curative effects and being safe and convenient to use for patients.

Description

technical field [0001] The invention belongs to the technical field of medical ointments, and in particular relates to a safe, effective and well-compliant traditional Chinese medicine compound gel plaster ointment and its preparation method and application, which are suitable for treating respiratory diseases. Background technique [0002] We disclosed "a compound angelica preparation and its preparation method and use" in Chinese patent 200810061131.5 (patent number ZL200810061131.5, patentee: Zhejiang University), which is based on 10-30g of angelica, 5-15g of fritillaria, and 2 -8g of Chinese medicine compound oral preparations, including oral liquids, sprays, aerosols, dripping pills, capsules or tablets, for the treatment of respiratory diseases, also disclosed in the embodiment of Chinese patent 200810061131.5 The preparation method of the above preparation, but the compound gel plaster of the present invention and its preparation method are not disclosed. [0003] G...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61K9/70A61K47/69A61P11/00A61P11/14A61P11/06A61P11/10A61P29/00
CPCA61K9/7023A61K36/232A61K36/489A61K36/8966A61K2236/33A61K2236/35A61K2300/00
Inventor 周长新葛婷甘礼社
Owner 杭州禾橼医药科技有限公司
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