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Nanometer contrast agent with lung-cancer-targeting magnetic resonance imaging capacity and preparation method of nanometer contrast agent

A magnetic resonance imaging and nano-contrast agent technology, applied in the field of radiodiagnostics, can solve the problems of uneven thickness of the surface coating layer, poor MRI imaging effect, poor liver and biliary tract imaging effect, etc., and achieve good biocompatibility and operation Simple, low-cost results

Inactive Publication Date: 2017-04-26
YIXING PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the superparamagnetic contrast agents that have been approved for marketing and are in clinical trials are composed of a core of ferric oxide particles and a layer of high polymer coated on the outside, with a particle size of about 25-40 nanometers. The synthesis process is complex, High manufacturing cost, large particle size, low crystallinity, poor MRI imaging effect, uneven thickness of surface coating
Most of the paramagnetic contrast agents currently used are organic complexes containing small molecule gadolinium, which are all extracellular reagents and are non-specifically distributed in the body. Poor imaging of the systems, which makes them unsuitable for use as selective (targeting) contrast agents

Method used

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  • Nanometer contrast agent with lung-cancer-targeting magnetic resonance imaging capacity and preparation method of nanometer contrast agent
  • Nanometer contrast agent with lung-cancer-targeting magnetic resonance imaging capacity and preparation method of nanometer contrast agent
  • Nanometer contrast agent with lung-cancer-targeting magnetic resonance imaging capacity and preparation method of nanometer contrast agent

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A method for preparing a nano-contrast agent capable of targeting magnetic resonance imaging of lung cancer, the specific steps are as follows:

[0028] Step 1: Put a certain amount of nickel acetylacetonate in a mixed solvent of oleylamine and octadecylamine (the mass ratio of oleylamine and octadecylamine is 1:2), heat it to 120°C until it completely dissolves into a green sticky When the liquid is thick, add the same molar amount of HAuCl dropwise 4 , raise the reaction temperature to 210°C at a heating rate of 5°C / min and magnetically stir for 1h, wherein the mixed solvent of oleylamine and octadecylamine is mixed with the total amount of metals added (nickel acetylacetonate and HAuCl 4 ) with a mass ratio of 100:0.6; after the reaction, when the temperature of the system drops to normal temperature, add a large amount of chloroform solution to dissolve the reactants and products in chloroform, and add an appropriate amount of octadecylamine under stirring until the...

Embodiment 2

[0036] A method for preparing a nano-contrast agent capable of targeting magnetic resonance imaging of lung cancer, the specific steps are as follows:

[0037] Step 1: Put a certain amount of nickel acetylacetonate in a mixed solvent of oleylamine and octadecylamine (the mass ratio of oleylamine and octadecylamine is 1:2), heat it to 120°C until it completely dissolves into a green sticky When the liquid is thick, add the same molar amount of HAuCl dropwise 4 , raise the reaction temperature to 200°C at a heating rate of 5°C / min and magnetically stir for 1.5h, wherein the mixed solvent of oleylamine and octadecylamine is mixed with the total amount of metals added (nickel acetylacetonate and HAuCl 4 ) with a mass ratio of 100:0.6; after the reaction, when the temperature of the system drops to normal temperature, add a large amount of chloroform solution to dissolve the reactants and products in chloroform, and add an appropriate amount of octadecylamine under stirring until t...

Embodiment 3

[0044] A method for preparing a nano-contrast agent capable of targeting magnetic resonance imaging of lung cancer, the specific steps are as follows:

[0045] Step 1: Put a certain amount of nickel acetylacetonate in a mixed solvent of oleylamine and octadecylamine (the mass ratio of oleylamine and octadecylamine is 1:2), heat it to 120°C until it completely dissolves into a green sticky When the liquid is thick, add the same molar amount of HAuCl dropwise 4 , raise the reaction temperature to 205°C at a heating rate of 5°C / min and magnetically stir for 1h, wherein the mixed solvent of oleylamine and octadecylamine is mixed with the total amount of metals added (nickel acetylacetonate and HAuCl 4 ) with a mass ratio of 100:0.6; after the reaction, when the temperature of the system drops to normal temperature, add a large amount of chloroform solution to dissolve the reactants and products in chloroform, and add an appropriate amount of octadecylamine under stirring until the...

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Abstract

The invention relates to a nanometer contrast agent with the lung-cancer-targeting magnetic resonance imaging capacity and a preparation method of the nanometer contrast agent, belonging to the technical field of radiodiagnostics. The preparation method of the nanometer contrast agent comprises the following steps: preparing asymmetrical Au-Ni nano-particles, preparing asymmetrical Au-Ni nano-particles with two modified ends, and preparing the nanometer contrast agent. The prepared nanometer contrast agent with the lung-cancer-targeting magnetic resonance imaging capacity has the good morphological control capacity, good biocompatibility and excellent lung cancer targeting property, can be well dispersed in a biological vector, and has the excellent magnetic resonance targeting imaging capacity for lung cancer cells. In addition, the preparation method provided by the invention is easy and convenient to operate, the adopted raw materials are easily available, and the cost is low.

Description

technical field [0001] The invention belongs to the technical field of radiodiagnosis, and in particular relates to a nano-contrast agent capable of targeting magnetic resonance imaging of lung cancer and a preparation method thereof. Background technique [0002] Lung cancer is one of the common malignant tumors in my country. Lung cancer lacks characteristic clinical manifestations in the early stage, and some patients are already in the middle and late stages of the disease when the disease is diagnosed. Therefore, it is particularly important to establish a more effective system to realize the early diagnosis of lung cancer. Currently, the contrast agents for magnetic resonance imaging (MRI) are superparamagnetic contrast agents and water-soluble paramagnetic contrast agents. superparamagnetic Fe 3 o 4 Imaging agent pair T 2 Time has a significant impact, and its main disadvantage is that in the darkened imaging mode, a relatively dark image is obtained, the contras...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/10
CPCA61K49/1833A61K49/10A61K49/186
Inventor 朱涛峰马铁梁陈如华谢婧罗一烽葛志军
Owner YIXING PEOPLES HOSPITAL
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