Method for preparing chitosan/sodium alginate natural polymer core-shell microspheres by one-step process

A technology of sodium alginate and polymer core, which is applied in the field of polymer materials and biomedical materials, can solve the problems of complex polymerization conditions and difficult control of the preparation process, and achieve good repeatability, low production cost and good application value Effect

Inactive Publication Date: 2017-04-26
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also people who initiate polymerization of two or more small molecular monomers under certain conditions through a one-step polymerization method to prepare polymer core-shell structure micr

Method used

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  • Method for preparing chitosan/sodium alginate natural polymer core-shell microspheres by one-step process
  • Method for preparing chitosan/sodium alginate natural polymer core-shell microspheres by one-step process
  • Method for preparing chitosan/sodium alginate natural polymer core-shell microspheres by one-step process

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Effect test

Embodiment 1

[0026] A method for preparing chitosan / sodium alginate natural polymer core-shell microspheres by one-step method, the preparation method is as follows:

[0027] (1) Prepare calcium chloride / chitosan mixed solution: get 15g chitosan solid powder, join in 500mL deionized water, stir 2 hours under normal temperature, then add the hydrochloric acid solution that molarity is 1.0mol / L to adjust the solution The pH is 5.5, and stirred for 8 hours until the chitosan is fully dissolved, and then filtered through a sand core funnel to prepare a chitosan solution that the mass volume ratio concentration is 3% (w / v); get 1.11g calcium chloride solid powder , added to 100mL of the above-mentioned chitosan solution, stirred at room temperature for 2 hours until the calcium chloride was completely dissolved, and the calcium chloride / chitosan mixed solution with a calcium chloride molar concentration of 0.1mol / L was prepared;

[0028] (2) Preparation of sodium alginate solution: Take 2g of s...

Embodiment 2

[0039] A method for preparing chitosan / sodium alginate natural polymer core-shell microspheres by one-step method, the preparation method is as follows:

[0040] (1) prepare calcium chloride / chitosan mixed solution: get 10g chitosan solid powder, join in 500mL deionized water, stir 2 hours under normal temperature, then add the hydrochloric acid solution that molarity is 1.0mol / L to adjust the solution The pH is 5.5, and stirred for 8 hours until the chitosan is fully dissolved, and then filtered through a sand core funnel to prepare a chitosan solution that the mass volume ratio concentration is 2% (w / v); get 0.222g calcium chloride solid powder , added to 50mL of the above-mentioned chitosan solution, stirred at room temperature for 2 hours until the calcium chloride was completely dissolved, and the calcium chloride / chitosan mixed solution with a calcium chloride molar concentration of 0.04mol / L was prepared;

[0041] (2) Preparation of sodium alginate solution: Take 1 g of...

Embodiment 3

[0044] A method for preparing chitosan / sodium alginate natural polymer core-shell microspheres by one-step method, the preparation method is as follows:

[0045] (1) Preparation of calcium chloride / chitosan mixed solution: get 30g chitosan solid powder, join in 600mL deionized water, stir for 1 hour at normal temperature, then add the hydrochloric acid solution that molar concentration is 1.2mol / L to adjust the solution The pH is 5.0, and stirred for 10 hours until the chitosan is fully dissolved, and then filtered through a sand core funnel to prepare a chitosan solution with a mass-volume concentration of 5% (w / v). Take 3.33g of calcium chloride solid powder, add it to 100mL of the above-mentioned chitosan solution, stir at room temperature for 3 hours until the calcium chloride is completely dissolved, and prepare calcium chloride / chitosan with a calcium chloride molar concentration of 0.3mol / L sugar mixture;

[0046] (2) Preparation of sodium alginate solution: Take 6g of...

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Abstract

The invention belongs to the field of polymer materials and bio-medical materials and particularly relates to a method for preparing chitosan/sodium alginate natural polymer core-shell microspheres by a one-step process. The method is characterized by comprising the following steps: firstly, preparing a calcium chloride/chitosan mixed solution and a sodium alginate solution; dripping the calcium chloride/chitosan mixed solution into the sodium alginate solution by use of a microinjector; placing to form microspheres; taking out the microspheres; and cleaning with distilled water to finally obtain the chitosan/sodium alginate natural polymer core-shell microspheres. The method has the advantages that the preparation process is simple, the preparation steps are simplified, the equipment is simple, the preparation conditions are mild, the control is easy, the repeatability is good, after-treatment is not needed, and the cost is low. The natural polymer materials which have the characteristics and advantages of being rich in source, green and environment-friendly, favorable in biocompatibility, non-toxic, biodegradable, and low in price are adopted as the preparation raw material, so that the prepared chitosan/sodium alginate natural polymer core-shell microspheres have a very high application value in the bio-medical field.

Description

technical field [0001] The invention belongs to the field of polymer materials and biomedical materials, in particular to a method for preparing chitosan / sodium alginate natural polymer core-shell microspheres by a one-step method. Background technique [0002] Natural polymer materials are widely used in the field of biomedical materials due to their rich sources, good biocompatibility and biodegradability, and no toxic or side effects. Chitosan is a biological polysaccharide with a wide range of sources, which has excellent properties such as good biocompatibility, biodegradability, and non-toxicity. Moreover, chitosan is a cationic polyelectrolyte amino polysaccharide, and chitosan has a pH-stimulus-responsive dissolution-insolubility transition property: when the pH of the solution is <6.0, the amino group on the chitosan molecular chain can be protonated to make the shell The polysaccharide dissolves, and when the pH of the solution increases (pH>6.0), the amino ...

Claims

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Application Information

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IPC IPC(8): B01J13/22B01J13/02C08L5/08C08L5/04C08K3/16
CPCB01J13/02B01J13/22C08L5/08C08L2203/02C08L2205/02C08L5/04C08K2003/162
Inventor 王艺峰周晶刘慧董梦秦超然雷健
Owner WUHAN UNIV OF TECH
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