Composite 3D printing molding system, molding method and vascular stent

Abstract

The invention relates to the field of tissue engineering, in particular to a composite 3D printing forming system combining the 3D printing technology and the electrospinning technology, a forming method and an intravascular stent. The composite 3D printing forming system at least comprises a 3D printing system, an electrospinning system and a forming table. The 3D printing system can print a 3D model on a refrigeration platform of the forming table, the electrospinning system can carry out electrospinning film forming on the 3D model, and a hollow tissue scaffold can be obtained by dissolving the 3D model. By means of the composite 3D printing forming system, the 3D printing technology and the electrospinning technology are combined, the advantages of the 3D printing technology and the electrospinning technology are combined, and the tissue scaffold which is provided with a precise three-dimensional structure and has the excellent mechanical property and biocompatibility can be achieved; and the forming method adopted by the composite 3D printing forming system and the intravascular stent obtained through the forming method and the composite 3D printing forming system are further provided.

Description

technical field [0001] The invention relates to the field of tissue engineering, in particular to a composite 3D printing forming system, forming method and vascular stent combining 3D printing technology and electrospinning technology. Background technique [0002] At present, cardiovascular diseases seriously affect human health, and in order to treat such diseases, vascular transplantation is a common solution. The sources of blood vessels used in the vascular grafting method include: autologous blood vessels, allogeneic blood vessels and artificial blood vessels. Among them, autologous blood vessels have the best effect, but their sources are limited and cause great damage to the donor site, while allogeneic blood vessels have problems such as immune rejection and limited sources. Based on the principles of bionics, the ultimate solution is to construct bionic artificial blood vessels through tissue engineering. Moreover, artificial blood vessels are also the basis for...

AI Technical Summary

Problems solved by technology

3D printing technology can accurately form complex three-dimensional structures, but it is difficult to construct small-diameter and multi-branched vascular systems: for example, artificial blood vessels manufactured by temperature phase change, because of the process, if gelatin, fibrinogen and Natural polymer materials such as sodium alginate have insufficient mechanical properties of artificial blood vessels; if synthetic polymer materials such as PLGA and PU are used, they will have certain mechanical properties only when they are piled up to a millimeter-level thickness. Millimeter-scale structures are quite different from natural blood vessels, and cannot be well used for the repair and regeneration of diseased blood vessels

Electrospinning technology can eject nano-scale fibers to form a film with excellent mechanical strength and biocompatibility, which provides a good microscopic environment for the subsequent adhesion, growth and migration of planted cells, but it must be based on a mold , to form a specific shape on the surface of the mold, and a single electrospinning device cannot accurately form complex three-dimensional structures

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