Hexahydropyrrolo-indole compound as well as preparation method and application thereof
A technology of hexahydropyrrole and compound, which is applied in organic chemistry, biocide-containing paint, antifouling/underwater coating, etc., can solve the problem that there are no detailed reports on the antifouling activity of indole compounds, and achieve novel structure , short synthesis steps and mild reaction conditions
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Embodiment 1
[0036] Synthesis of Hexahydropyrroloindoles. This example provides the synthesis steps of the hexahydropyrroloindole compounds, specifically as follows:
[0037] 1. Synthesis of oxindole-3-acetonitrile
[0038]
[0039] Weigh 3.12g (20mmol) of indole-3-acetonitrile in a 250mL dry round bottom flask, add 30mL DMSO, stir at room temperature for 15min to dissolve completely, place the reaction solution in an ice bath at 0°C, and then use Slowly add 150 mL of concentrated hydrochloric acid (37% HCl, V DMSO :V HCl =1:5), after the dropwise addition was complete, the reaction solution was moved to room temperature and stirred for 30 min, and TLC (PE:EA=4:1) detected that the reaction of the raw materials was complete. The reaction solution was placed in an ice bath at 0°C, diluted with 50 mL of water, and washed with anhydrous K 2 CO 3 or anhydrous Na 2 CO 3The pH value of the solid is adjusted, and the pH value of the solution is detected while stirring, and the pH value ...
Embodiment 2
[0056] Determination of the fungicidal activity of hexahydropyrroloindole compounds.
[0057] Determination of N-formic acid methyl hexahydropyrrole-5-formic acid methyl ester-[2,3]-N-triazole (N-butyl)-indole on Staphylococcus aureus (staphylococcus aureus) and Bacteriostatic activity of Escherichia coli. All strains used were purchased from the China General Microorganism Culture Collection Center.
[0058] Using the test tube double dilution method, take a sterilized test tube added with 2 mL of liquid medium, use the test tube inoculated without the test compound as the positive control, and use the test tube without the test compound and inoculated as the negative control. The initial mass concentration of the drug is 1g / L, which is diluted by two times successively and mixed evenly. Add 200 μL of a certain mass concentration of bacterial suspension to each test tube, so that the final bacterial concentration is 10 4 ~10 5 cfu / mL (cfu is the colony forming unit, 1cfu ...
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