Propranolol hydrochloride gel and preparation method thereof

The technology of propranolol hydrochloride gel and propranolol hydrochloride gel is applied in the field of medicine and can solve the problems of insignificant improvement of transdermal absorption performance, strong volatility and irritation, and unsuitability for use by infants and young children. , to avoid liver first-pass effect, suitable viscosity and convenient administration.

Active Publication Date: 2019-08-27
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Propranolol hydrochloride is a water-soluble drug, and its transdermal absorption performance is extremely poor. In the prior art, the improvement of transdermal absorption performance is not obvious; and the commonly used transdermal penetration enhancers menthol, camphor, Borneol, etc. are highly volatile and irritating; turpentine, anethole, etc. have certain skin toxicity, and are likely to cause irritation and allergic reactions such as redness, heat pain, etc. on the skin of infants and young children, and are not suitable for infants and young children.

Method used

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  • Propranolol hydrochloride gel and preparation method thereof
  • Propranolol hydrochloride gel and preparation method thereof
  • Propranolol hydrochloride gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Weigh 3g propranolol hydrochloride, 0.1g ethylparaben, add appropriate amount of purified water to dissolve and disperse,

[0072] Slowly add 20g poloxamer (P407) in this solution, stir this solution evenly, make poloxamer all be submerged below the water surface, be placed in the refrigerator of 4 ℃, make it fully swell.

[0073] After 24 hours, take out the swollen solution, add 5 g of propylene glycol, 4 g of azone, and 5 g of glycerin while stirring, and stir evenly to obtain a colorless and transparent propranolol hydrochloride gel preparation.

Embodiment 2

[0075] Weigh 3g propranolol hydrochloride, 0.1g sorbic acid, add appropriate amount of purified water to dissolve and disperse,

[0076] Slowly add 20g of sodium alginate to the solution, stir the solution evenly so that all the sodium alginate is submerged below the water surface, and place it in a refrigerator at 4°C to make it fully swell.

[0077] After 24 hours, take out the swollen solution, add 5 g of propylene glycol, 5 g of azone, and 5 g of glycerin while stirring, and stir evenly to obtain a colorless and transparent propranolol hydrochloride gel preparation.

Embodiment 3

[0079] Take by weighing 3g propranolol hydrochloride, add appropriate amount of purified water to dissolve and disperse 0.1g ethylparaben,

[0080] Slowly add 20g of poloxamer P188 to the solution, stir the solution evenly, make the poloxamer all submerged below the water surface, place it in a refrigerator at 4°C, and make it fully swell.

[0081] After 24 hours, take out the swollen solution, add 5 g of glycerin, 6 g of propylene glycol, and 4 g of azone while stirring, and stir evenly to obtain a colorless and transparent propranolol hydrochloride gel preparation.

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PUM

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Abstract

The invention relates to the technical field of medicine and provides propranolole hydrochloride gel and a preparation method thereof. The propranolole hydrochloride gel is mainly prepared from the ingredients of bulk drug propranolole hydrochloride, penetration enhancer, humectant, preservative, gel substrate and water. A propranolole hydrochloride gel preparation prepared by the invention has the characteristics of being even, fine, appropriate in viscosity, easy to smear and free of irritation to skin; when being applied to treating subcutaneous-layer infantile hemangioma, the propranolole hydrochloride gel preparation is convenient to dose and avoids a first-pass effect of the liver; furthermore, the gel preparation can form a drug storage library on the skin, so that a slow-release function is achieved; meanwhile, the gel preparation is better in child patient adaptability and has good application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a propranolol hydrochloride gel and a preparation method thereof. Background technique [0002] Infantile hemangioma is a benign tumor that often occurs in infants. In newborns, its incidence rate is 1.1% to 2.6%, and 2 / 3 occur in the head and neck. Among them, the incidence rate of infants under 1 year old is as high as 10%. ~12%, the incidence of hemangiomas in infants and young children is high. Generally, those with mild symptoms and small tumors may subside on their own, but those that occur in special parts, such as the face, mouth, eyes, and respiratory tract, may cause disfigurement and functional damage , In some cases, it will be accompanied by complications such as ulcers and bleeding, and even life-threatening, so it must be treated reasonably. [0003] Traditionally, hormonal drugs, surgery, etc. have caused relatively large side effects in the treatment of infanti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/138A61K47/10A61K47/22A61P35/00
Inventor 刘继勇顾永卫顾清薛春雨姜琳莉杨盟唐晓萌陆松伟陈方剑
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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