Anti-restenosis intraluminal stent material

Abstract

The invention discloses an anti-restenosis intraluminal stent material. The anti-restenosis intraluminal stent material comprises a biocompatible endoprosthesis material, a micro slot, a composition capable of being degraded to release Fe<3+>, a degradable polymer coating and a short peptide layer, wherein the biocompatible endoprosthesis material comprises a basal body; a material of the basal body is degradable in a tissue body; the basal body is tubular, and has tubular inner and outer surfaces, and the inner surface forms a channel for allowing a tissue fluid, for example, blood, to pass through; the micro slot is positioned in the outer surface, the depth of the micro slot is smaller than the thickness of the tubular basal body, the micro slot can be a rectangular groove parallel to the axial direction of the basal body or an annular groove along the perimeter of the basal body or a W-shaped groove in the axial direction of the basal body; the composition capable of being degraded to release the Fe<3+> is loaded in a micro cavity, and can be degraded in the tissue to release the Fe<3+>; the degradable polymer coating coats on inner and outer surfaces of the basal body, and a degradation rate of the coating is higher than that of the basal body; the short peptide layer coats on the degradable polymer coating, and comprises a first short peptide and a second short peptide; the first short peptide and the second short peptide can be self-assembled to form hydrogel; and the hydrogel formed by self-assembling the short pepetide layer can be specially beneficial for climbing and covering of endothelial cells and regenerating of endodermis.

Description

Background technique [0001] The invention belongs to the field of medical materials, and in particular relates to an anti-restenosis intraluminal stent material, in particular, an anti-restenosis vascular stent material. [0002] In 1987, Sigwart et al. used intravascular metal stents for coronary arteries for the first time, and received unexpected results, which provided a good way for the treatment of vascular occlusion diseases. Coronary artery stent is a kind of intravascular stent made of metal stainless steel, which has good plasticity and geometric stability, and can be sent to the lesion site through a catheter in a closed state, and then expanded by balloon expansion. Play a role in supporting blood vessels. Coronary artery stent implantation effectively avoids acute atresia, elastic recoil, and abnormal vascular remodeling of the vessel wall after balloon dilation, making the initial lumen enlargement more obvious and the rate of restenosis (ISR) significantly redu...

AI Technical Summary

Problems solved by technology

Synthetic grafts have also been inoculated with endothelial cells, but the clinical outcome of endothelial inoculation is generally poor, most likely due to nonadhesive properties of the cells to the graft and / or loss of EC function due to ex vivo manipulation

CN105327399 provides a method for constructing artificial blood vessels, which introduces prokaryotic system expression vectors with hydrophilic and negatively charged polypeptide genes and cell adhesion-promoting polypeptide genes on the surface (Journal of DonghuaUniversity (English Edition), 2012, 29:26 -29; Bio-Medical Materials and Engineering, 2014, 24:2057–2064), which improves surface hydrophilicity and negative charge, increases endothelialization potential, and is beneficial to tissue healing and anticoagulation, but this technology is suitable for constructing artificial blood vessels, The materials used include polyester. Obviously, for the field of vascular stents that need to be degraded after vascular stenosis treatment, this material has natural non-biocompatibility and cannot provide the mechanical support properties required by vascular stents. At the same time, as mentioned above As mentioned above, if endothelial cell proliferation cannot maintain homeostasis, it will lead to the formation of vascular restenosis

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