Preparation of silver-gold alloy nanometer spherical shell based on vapreotide acetate

A technology of silver-gold alloy and vapreotide, which is applied in the field of preparation of nanomaterials, can solve problems affecting the performance of nanomaterials, uneven particle distribution, and large particle size differences, and achieve high biocompatibility, simple structure, and particle size. The effect of uniform diameter

Active Publication Date: 2017-05-24
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in previous preparation studies, due to the special morphology and special bond interactions of the alloy nanosphere shell, its morphology is not easy to control, the particle distribution on the surface of the spherical shell is uneven, the particle size varies greatly, and the product purity is also lower, which greatly affects the properties of nanomaterials
Moreover, these preparation methods generally have the disadvantages of polluting the environment, complicated process, and high cost.

Method used

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  • Preparation of silver-gold alloy nanometer spherical shell based on vapreotide acetate
  • Preparation of silver-gold alloy nanometer spherical shell based on vapreotide acetate
  • Preparation of silver-gold alloy nanometer spherical shell based on vapreotide acetate

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Effect test

Embodiment 1

[0023] Get 0.91 mg of vapreotide acetate (Wuhan Dongkangyuan Technology Co., Ltd.), dissolve it in 1 mL of hydrochloric acid solution with pH 5.0, and prepare a vapreotide acetate solution with a concentration of 0.8 mM, place the vapreotide acetate solution in 65°C metal bath for 20 minutes; mix 500 μL of vapreotide acetate solution after the metal bath with 500 μL of 3.0 mM silver nitrate solution (Tianjin Chemical Reagent Factory) and put it into a constant temperature oscillator in a water bath. The control speed is 122 rpm and the temperature is 24°C Incubate under the condition for 24 hours; add 30 μL of 60 mM sodium borohydride (produced by Beijing Zhongsheng Huateng Technology Co., Ltd.) dropwise for reduction, the dropping speed is 3 drops / min, 30 μL / drop, the temperature is 24 ° C, and react for 16 min until the solution is from until the transparent slowly turns gray-black; finally, put the above-prepared solution in a boiling water bath at 100°C for 10 minutes, add ...

Embodiment 2

[0026] Take 1.02 mg of vapreotide acetate (Wuhan Dongkangyuan Technology Co., Ltd.), dissolve it in 1 mL of hydrochloric acid solution with pH 6.0, and prepare a vapreotide acetate solution with a concentration of 0.9 mM, and place the vapreotide acetate solution in 66°C metal bath for 22 minutes; mix 500 μL of vapreotide acetate solution after the metal bath with 500 μL of 6.0 mM silver nitrate solution (Tianjin Chemical Reagent Factory) and put it into a water bath constant temperature oscillator, control the speed at 124 rpm, and the temperature at 24°C Incubate under these conditions for 25 hours; add 60 μL of 80 mM sodium borohydride (produced by Beijing Zhongsheng Huateng Technology Co., Ltd.) dropwise for reduction, at a rate of 3 drops / minute, 30 μL / drop, at a temperature of 24°C, and react for 17 minutes until the solution changes from until the transparent slowly turns gray-black; finally, put the above-prepared solution in a boiling water bath at 100°C for 10 minutes...

Embodiment 3

[0029] Take 1.13 mg of vapreotide acetate (Wuhan Dongkangyuan Technology Co., Ltd.), dissolve it in 1 mL of hydrochloric acid solution with pH 7.0, and prepare a vapreotide acetate solution with a concentration of 1.0 mM, and place the vapreotide acetate solution in 67℃ metal bath for 24min; mix 500μL of vapreotide acetate solution after the metal bath with 500μL of 9.0mM silver nitrate solution (Tianjin Chemical Reagent Factory) and put it into a water bath constant temperature oscillator, control the speed at 126rpm, and the temperature at 24℃ Incubate under the condition for 26 h; add 90 μL of 100 mM sodium borohydride (produced by Beijing Zhongsheng Huateng Technology Co., Ltd.) dropwise for reduction, the dropping speed is 3 drops / min, 30 μL / drop, the temperature is 24 ° C, and the reaction is 18 min until the solution is from until the transparent slowly turns gray-black; finally, put the above-prepared solution in a boiling water bath at 100°C for 10 minutes, add 200 μL ...

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Abstract

Provided is a preparation method of a silver-gold alloy nanometer spherical shell based on vapreotide acetate. The preparation method mainly comprises the steps that according to the proportion that 0.91-1.13 mg of vapreotide acetate is added to 1 ml of a hydrochloric acid solution, a vapreotide acetate solution is prepared, and treatment is conducted for 20-24 min at the temperature of 65-67 DEG C; a silver nitrate solution is added according to the ratio of 1 to 3-9, a mixture is put into a water bath constant-temperature oscillator, and incubation is conducted for 24-26 h at the temperature of 24 DEG C; according to the molar ratio of 1 to 1-2 of silver nitrate and sodium borohydride, reducing agent sodium borohydride is added dropwise, and a reaction is conducted for 16-18 min at the temperature of 24 DEG C; the mixture is put into a 100-DEG C boiling water bath, 10 min later, a auric chloride solution is added according to the molar ratio of 1 to 25-45 of auric chloride and the silver nitrate, the mixture is put into the 100-DEG C boiling water bath for 2-4 min, and the silver-gold alloy nanometer spherical shell with the grain size of 90-110 nm is prepared. By the adoption of the preparation method, the morphology is easy to control, the operation is simple, environmental protection is achieved, the reaction condition is gentle, and prepared silver-gold alloys are uniform in grain size and good in dispersity.

Description

technical field [0001] The invention belongs to the technical field of nanometer metal materials, and in particular relates to a preparation method of nanometer materials. Background technique [0002] The special properties of gold and silver nanoparticles have received extensive attention. Their surface properties, small size properties and excellent monodispersity have been used in various fields, in various chemical analysis, chemical catalysis, optical switches, sensors, There are potential application prospects in the fields of bioanalysis and biomedical detection. Many properties of gold and silver nanoparticles depend on the size and shape of the gold and silver nanoparticles. A large ratio of surface atoms can greatly enhance its surface activity; the unique surface structure, electronic state and atomic arrangement will make it have unique material properties, and can also promote some characteristic chemical reactions, leading to their catalytic properties Diffe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/065B22F1/054
Inventor 高大威李彦集高发明边可新尹甜牛康刘欢
Owner YANSHAN UNIV
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