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High-quantum-yield electrochemiluminescence gold nano-cluster probe and preparation method of high-quantum-yield electrochemiluminescence gold nano-cluster probe

A technology of gold nanoclusters and electrochemistry, applied in the field of nanometers, to achieve the effects of high luminous intensity, good biocompatibility and good reproducibility

Inactive Publication Date: 2017-05-24
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports on the use of gold nanoclusters as ECL probes for ECL sensing.

Method used

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  • High-quantum-yield electrochemiluminescence gold nano-cluster probe and preparation method of high-quantum-yield electrochemiluminescence gold nano-cluster probe

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Experimental program
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Effect test

Embodiment 1

[0039]Add 0.6 mL of 0.5 mol / L sodium hydroxide and 0.4 mL of 20 mg / mL chloroauric acid solution to 4 mL of 0.08 mol / L N-acetyl-L-cysteine ​​solution, mix After uniformity, they were placed in a 37°C constant temperature water tank and incubated for 3 hours. After the reaction, the reaction solution was purified by dialysis using a dialysis bag with a molecular cutoff of 3500 to obtain an aqueous solution of N-acetyl-L-cysteine-gold nanoclusters. Glassy carbon electrodes with a diameter of 3 mm were coated with 1.0 μm, 0.3 μm and 0.05 μm Al 2 o 3 The powder is polished and polished in turn until it reaches a smooth mirror surface, and then put in HNO in turn 3 Solution (volume ratio of concentrated nitric acid to water is 1:1), absolute ethanol, ultrasonic cleaning in deionized water for 3 minutes, and blow dry with nitrogen gas. Take 5 μL of N-acetyl-L-cysteine-protected gold nanocluster solution and drop it on the surface of the treated glassy carbon electrode, and dry it ...

Embodiment 2

[0041] Add 0.6 mL of 0.5 mol / L sodium hydroxide and 0.4 mL of 20 mg / mL chloroauric acid solution to 4 mL of 0.08 mol / L N-acetyl-L-cysteine ​​solution, mix After uniformity, they were placed in a 37°C constant temperature water tank and incubated for 3 hours. After the reaction, the reaction solution was purified by dialysis using a dialysis bag with a molecular cutoff of 3500 to obtain an aqueous solution of N-acetyl-L-cysteine-gold nanoclusters. Glassy carbon electrodes with a diameter of 3 mm were coated with 1.0 μm, 0.3 μm and 0.05 μm Al 2 o 3 The powder is polished and polished in turn until it reaches a smooth mirror surface, and then put in HNO in turn 3 Solution (volume ratio of concentrated nitric acid to water is 1:1), absolute ethanol, ultrasonic cleaning in deionized water for 3 minutes, and blow dry with nitrogen gas. Take 5 μL of N-acetyl-L-cysteine-protected gold nanocluster solution and drop it on the surface of the treated glassy carbon electrode, and dry it...

Embodiment 3

[0043] Add 0.6 mL of 0.5 mol / L sodium hydroxide and 0.4 mL of 20 mg / mL chloroauric acid solution to 4 mL of 0.08 mol / L N-acetyl-L-cysteine ​​solution, mix After uniformity, they were placed in a 37°C constant temperature water tank and incubated for 3 hours. After the reaction, the reaction solution was purified by dialysis using a dialysis bag with a molecular cutoff of 3500 to obtain an aqueous solution of N-acetyl-L-cysteine-gold nanoclusters. Glassy carbon electrodes with a diameter of 3 mm were coated with 1.0 μm, 0.3 μm and 0.05 μm Al 2 o 3 The powder is polished and polished in turn until it reaches a smooth mirror surface, and then put in HNO in turn 3 Solution (volume ratio of concentrated nitric acid to water is 1:1), absolute ethanol, ultrasonic cleaning in deionized water for 3 minutes, and blow dry with nitrogen gas. Take 5 μL of N-acetyl-L-cysteine-protected gold nanocluster solution and drop it on the surface of the treated glassy carbon electrode, and dry it...

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Abstract

The invention discloses a high-quantum-yield electrochemiluminescence gold nano-cluster probe and a preparation method of the high-quantum-yield electrochemiluminescence gold nano-cluster probe. The high-quantum-yield electrochemiluminescence gold nano-cluster probe disclosed by the invention is prepared by taking a functional gold nano-cluster material as a precursor and adopting a chemical reduction method. The electrochemiluminescence gold nano-cluster probe is modified on an electrode, takes persulfate ions as a co-reaction reagent and has good electrochemiluminescence performance. The high-quantum-yield electrochemiluminescence gold nano-cluster probe has the characteristics that a process is simple, the repeatability is good, an electrochemiluminescence signal of the probe is strong and stable, the luminescence efficiency is high and the like. The high-quantum-yield electrochemiluminescence gold nano-cluster probe prepared by the invention has a relatively good application prospect in the fields of medicines, chemistry, biology, environment and the like.

Description

technical field [0001] The invention discloses a high-quantum-yield electrochemiluminescence gold nano-cluster probe and a preparation method thereof, belonging to the field of nanotechnology. Background technique [0002] Electrochemiluminescence is based on an electrochemical method, through which certain substances in the sample to be tested generate an unstable excited state after an electrochemical reaction, and light radiation is generated when the intermediate substance in the excited state returns to the ground state. Due to its simple equipment, good reproducibility, high sensitivity and selectivity, and in-situ detection, electrochemiluminescence has been widely used in the fields of medicine, chemistry, life science, and environmental science. In recent years, the use of electrochemiluminescent materials with high sensitivity and good biocompatibility in biological analysis and medical detection has attracted extensive attention of researchers. [0003] Gold nano...

Claims

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Application Information

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IPC IPC(8): G01N21/76G01N27/327
CPCG01N21/76G01N27/3277
Inventor 陈伟彭花萍简美丽王文俊林秀玲
Owner FUJIAN MEDICAL UNIV
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