Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Febrifugine liposome and preparation method thereof

A technology of hibiscus and liposomes, which is applied in the direction of liposome delivery, anti-infective drugs, and drug combinations, etc. It can solve the problems of low bioavailability, affecting the effect of drug administration, and short administration time, and achieves improved physical and chemical properties. properties, improved atomization effect, uniform distribution effect

Inactive Publication Date: 2017-05-31
HENAN SOAR VETERINARY PHARMA +1
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Stenosine is a fat-soluble substance, which has poor dissolution in the body and low bioavailability, resulting in short administration time and small area, which affects the administration effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Febrifugine liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of changshanine liposome:

[0021] (1) Dissolve changshanine and liposome encapsulating material in supercritical CO 2 / Obtain a supercritical solution in anhydrous ethanol mixed solvent;

[0022] (2) Dissolve the surfactant as a stabilizer in a pH=7, 0.01mol / L phosphate buffer to obtain a stabilizer solution;

[0023] (3) The supercritical solution is sprayed into the stabilizer solution at a spray speed of 60ml / sec under the set expansion pressure of 30MPa and the expansion temperature of 350K, and the solution is dispersed and precipitated to obtain the changshanine liposome mixture Suspension

[0024] Wherein, the liposome encapsulating material is tricaprylin; the mass ratio of ashenine to liposome encapsulating material is 1:10; supercritical CO 2 / In anhydrous ethanol mixed solvent, anhydrous ethanol and CO 2 The volume ratio is 1:10; the surfactant is Tween 80, and the concentration of the stabilizer solution is 10% by mass fraction.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
melting pointaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a febrifugine liposome and a preparation method thereof. The preparation method comprises the following steps: dissolving febrifugine and a liposome encapsulating material in a supercritical CO2 / ethanol mixed solvent to obtain a supercritical solution; dissolving a surfactant used as a stabilizer in a water phase medium to obtain a stabilizer solution; and spraying the supercritical solution to the stabilizer solution under 20-30 MPa at 300-350 K, and carrying out dispersion and precipitate precipitation to obtain the febrifugine liposome, wherein the liposome encapsulating material is tricaprylin, and a mass ratio of febrifugine to the liposome encapsulating material is 1:10 to 1:20; a volume ratio of ethanol to CO2 in the supercritical CO2 / ethanol mixed solvent is 1:6 to 1:10; the surfactant is tween80; the water phase medium is a phosphate buffer solution; and the concentration of the stabilizer solution is 1-10 wt%. The method for preparing the febrifugine liposome by adopting a supercritical CO2 fluid technology has the advantages of no toxic organic solvents and mild conditions, and allows the encapsulating rate to be higher than 80%.

Description

Technical field [0001] The invention belongs to the field of veterinary medicine, and specifically relates to a changshanine liposome and a preparation method thereof. Background technique [0002] Changshanine is a quinazolone alkaloid with the molecular formula C 16 H 19 N 3 O 3 , Is the active ingredient in Changshan, a traditional Chinese medicine for malaria. In 1949, Chinese chemist Zhao Chenggu and others obtained it from Chang Shangen. [0003] There are three kinds of changshanine: a, β and γ. β-Changshanine, also known as antipyretic alkali, is the main alkaloid in Changshan root; its melting point is 139~140℃; it is hardly soluble in water and ethanol, and easily soluble in chloroform, methanol or a mixture of chloroform and dilute ethanol. a-Changshanine is also called metapyretic alkali; its melting point is 129~130℃; its properties are similar to β-Changshanine, but its solubility is greater in chloroform or acetone. The melting point of γ-changshanine is 161℃. Ch...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/517A61K47/14A61K47/26A61P33/06
CPCA61K9/1272A61K31/517A61K47/26
Inventor 孙江宏刘素梅阮心洁高贵超
Owner HENAN SOAR VETERINARY PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com