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Method for rapidly detecting concentration process of extracting solution during preparation of Qizhiweitong granules with NIRS (near infrared spectroscopy) and application

A near-infrared spectroscopy and near-infrared spectroscopy technology, which is applied in the direction of measuring devices, specific gravity measurement, and material analysis through optical means, can solve the problem that it is difficult to reflect the chemical and physical changes in the extraction process, affect production efficiency, and inefficiency and other issues to achieve the effect of shortening the detection time, improving economic benefits, and improving production efficiency

Inactive Publication Date: 2017-05-31
本溪国家中成药工程技术研究中心有限公司 +1
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Problems solved by technology

However, due to the low efficiency of traditional analysis methods, not only greatly affects the production efficiency, but also it is difficult to reflect the complex chemical and physical changes in the extraction process and concentration process

Method used

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  • Method for rapidly detecting concentration process of extracting solution during preparation of Qizhiweitong granules with NIRS (near infrared spectroscopy) and application
  • Method for rapidly detecting concentration process of extracting solution during preparation of Qizhiweitong granules with NIRS (near infrared spectroscopy) and application
  • Method for rapidly detecting concentration process of extracting solution during preparation of Qizhiweitong granules with NIRS (near infrared spectroscopy) and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Example 1 Study on the Concentration Process of Extract by Using Near Infrared Spectroscopy in the Preparation of Qizhiweitong Granules

[0073] 1. Experimental materials

[0074] 1.1 Medicinal materials and reagents

[0075] Qi stagnation Weitong granule concentrate (provided by Liaoning China Resources Benxi Sanyao Co., Ltd.); paeoniflorin reference substance (Chengdu Master Biotechnology Co., Ltd., batch number: MUST-11030608); acetonitrile (Merck, Germany); phosphoric acid (Aladdin); Wahaha pure water.

[0076] 1.2 Main instruments and equipment

[0077] Agilent1200 high-performance liquid chromatography (Agilent1200 pump, Agilent1200 photoelectric secondary array detector, Agilent1200 chromatographic workstation, Agilent Technologies, USA); Antaris Fourier transform near-infrared spectrometer (Thermo Nicolet, USA); equipped with a corresponding transmission detector accessory sampling system and signal acquisition and data processing software such as Result an...

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Abstract

The invention relates to a method for rapidly detecting a concentration process of an extracting solution during preparation of Qizhiweitong granules with NIRS (near infrared spectroscopy) and an application. An NIRS online analysis method for the concentration process of the extracting solution during preparation of the Qizhiweitong granules is established and applied to online detection, and automatic detection of the concentration process of the extracting solution during preparation of the Qizhiweitong granules and real-time prediction of content of various quality control indexes are realized; an established model is high in prediction precision and accuracy and meets the requirement of quantitative analysis in actual production; compared with the traditional pharmacopoeia method, the method has the advantages that the analysis efficiency is increased greatly on the basis of accuracy, and the quality of the concentration process of the extracting solution can be monitored and controlled in real time rapidly and efficiently, so that the safety, the stability and the effectiveness of the final product quality are guaranteed.

Description

technical field [0001] The invention belongs to the field of drug detection, and specifically relates to a method and application for rapidly detecting the concentration process of an extract in the preparation process of qi stagnation stomach pain granules by using near-infrared spectroscopy. Background technique [0002] Qi stagnation stomach pain granules are made of 6 traditional Chinese medicines of Bupleurum, Corydalis Corydalis, Fructus Citrifolia, Cyperi Cyperi, Radix Paeoniae Alba and Radix Glycyrrhiza. The treatment of epigastric pain and other diseases has become the first-line drug for clinical treatment of epigastric pain after years of clinical practice. However, the preparation process of Qizhi Weitong Granules is complex and cumbersome, and slight changes in various process parameters in the actual production process may directly affect the quality of the final drug. [0003] Traditional drug analysis techniques generally use off-line analysis methods to col...

Claims

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Application Information

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IPC IPC(8): G01N21/359G01N21/3577G01N9/24
CPCG01N21/359G01N9/24G01N21/3577
Inventor 孟宪生刘雪松谈英张跃飞韩凌曲艳国韩晓妮何晓霞潘英包永睿王帅李天娇索轶平
Owner 本溪国家中成药工程技术研究中心有限公司
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