A preparation method of a multifunctional iron-cobalt magnetic nanosensor, its products and applications
A magnetic nanometer and magnetic nanoparticle technology, applied in the field of nanosensors, can solve the problems of slow binding kinetics of recognition probes, low ECL efficiency of light emitters, low sensitivity and selectivity, etc., to improve steric hindrance and improve luminous efficiency , excellent selective effect
Active Publication Date: 2019-04-30
SOUTHWEST UNIV
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Problems solved by technology
However, almost all ECL biosensors are heterogeneous analysis modes (for example, the analysis of gold electrode and glassy carbon electrode surface), which is usually accompanied by some inherent disadvantages: (1) limited reaction area and inherent steric hindrance lead to Recognition probes have relatively slow binding kinetics and low recognition efficiency, resulting in low sensitivity and selectivity; (2) contamination of electrodes can lead to relatively low reproducibility; (3) luminophores have low ECL efficiency, resulting in relatively low sensitivity
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Embodiment 1
[0025] The preparation method of the multifunctional iron-cobalt magnetic nanosensor is as follows:
[0026] 1) CoFe 2 o 4 Preparation of magnetic nanoparticles: Co(NO 3 ) 2 ·6H 2 O and FeCl 3 ·6H 2 O was dissolved in ethylene glycol to obtain a clear solution, then sodium acetate, urea and polyethylene glycol were added to the solution and stirred to obtain a reddish-brown mixture, and the reddish-brown mixture was transferred to a polytetrafluoroethylene-lined stainless steel reactor. React at 150-200°C for about 8-12 hours. Finally, further centrifugation to obtain a black precipitate, which was washed alternately with deionized water and ethanol under a magnetic field, and further dried to obtain CoFe 2 o 4 magnetic nanoparticles;
[0027]2) Dopamine functionalized CoFe 2 o 4 The preparation of magnetic nanoparticles: the CoFe obtained in step 1) 2 o 4 Magnetic nanoparticles were ultrasonically dissolved in tetrahydrofuran solution, further adding dopamine aqu...
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Abstract
The invention discloses a manufacturing method for a multifunctional Fe-Co magnetic nanosensor, a product thereof and application of the Fe-Co magnetic nanosensor. The method comprises the following steps: 1) preparing CoFe2O4 magnetic nanoparticles; 2) preparing dopamine functional CoFe2O4 magnetic nanoparticle; 3) preparing nano-Au@CoFe2O4 magnetic nanoparticles; 4) manufacturing the multifunctional CoFe2O4 magnetic sensor. The manufactured multifunctional Fe-Co magnetic nanosensor is applied to detection of ions, proteins and DNA (Deoxyribonucleic Acid). As proved by further verification of the embodiment, the manufactured multifunctional CoFe2O4 magnetic nanosensor shows high sensitivity, superior selectivity and high reproducibility when being applied to the detection of Cu<2+>.
Description
technical field [0001] The invention belongs to the field of nanometer sensors, and in particular relates to a preparation method of a multifunctional iron-cobalt magnetic nanometer sensor and its products and applications. Background technique [0002] Constructing a highly sensitive sensing platform for the quantitative detection of ions, proteins and DNA has always been the focus of environmental testing, clinical experiments and basic research. In recent years, electrochemiluminescence (ECL), as a powerful analytical technique, has shown great potential in biological analysis due to its simplified optical setup, low background signal and high sensitivity. However, almost all ECL biosensors are heterogeneous analysis modes (for example, the analysis of gold electrode and glassy carbon electrode surface), which is usually accompanied by some inherent disadvantages: (1) limited reaction area and inherent steric hindrance lead to Recognition probes have relatively slow bind...
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IPC IPC(8): G01N21/76
CPCG01N21/76
Inventor 卓颖梁文斌雷燕梅柴雅琴袁若
Owner SOUTHWEST UNIV