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A kind of compound lidocaine cream medicinal composition and preparation method thereof

A technology of compound lidocaine cream and lidocaine cream, which is applied in the field of medicine, can solve problems such as easy moisture absorption and difficult storage, and achieve the effects of reducing alkalinity, convenient medication, and good product quality

Active Publication Date: 2021-05-25
SICHUAN HAISCO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Prilocaine free base is needle crystal, melting point 37-38℃, easy to absorb moisture, difficult to store

Method used

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  • A kind of compound lidocaine cream medicinal composition and preparation method thereof
  • A kind of compound lidocaine cream medicinal composition and preparation method thereof
  • A kind of compound lidocaine cream medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044]Embodiment 1 The preparation of compound lidocaine cream pharmaceutical composition

[0045] Prescription composition (preparation of 10kg cream):

[0046]

[0047] Preparation:

[0048] (1) Water phase preparation: Weigh Carbomer 974P according to the prescription amount, and measure purified water according to the prepared 1.2% Carbomer 974P aqueous solution, slowly add Carbomer 974P to the purified water, stir for more than 1 hour to dissolve completely Aqueous phase is obtained;

[0049] (2) Oil phase preparation: take lidocaine and prilocaine according to the prescription in the main pot, stir and mix evenly at 40-50°C, melt to a transparent liquid, and obtain lidocaine-prilocaine eutectic; The prescription amount of polyoxyethylene 40 hydrogenated castor oil is completely melted at 60°C, then added to the eutectic, and stirred evenly to prepare the oil phase for later use;

[0050] (3) Prepare 10% sodium hydroxide solution with purified water according to the...

Embodiment 2

[0059] Embodiment 2 Preparation of Compound Lidocaine Cream Pharmaceutical Composition

[0060] Prescription composition (preparation of 45kg cream):

[0061]

[0062] Preparation:

[0063] (1) Water phase preparation: slowly add the prescribed amount of Carbomer 940 into 18525 g of purified water, stir for more than 1 hour to completely dissolve to obtain the water phase;

[0064] (2) Oil phase preparation: take lidocaine and prilocaine according to the prescription in the main pot, stir and mix evenly at 40-50°C, melt to a transparent liquid, and obtain lidocaine-prilocaine eutectic; Recipe amount of polyoxyethylene 80 hydrogenated castor oil is completely melted at 60°C, then added to the eutectic, stirred evenly to prepare the oil phase for later use;

[0065] (3) Prepare 10% sodium hydroxide solution with purified water according to the prescription quantity;

[0066] (4) Emulsification: Measure the remaining amount of purified water and add it to the oil phase prep...

Embodiment 3

[0068] Example 3 Preparation of Compound Lidocaine Cream Pharmaceutical Composition

[0069] Prescription composition (preparation of 10kg cream):

[0070]

[0071] Preparation:

[0072] (1) Water phase preparation: weigh Carbomer 934 according to the prescription amount, and measure purified water according to the prepared 0.5% Carbomer 934 aqueous solution, slowly add Carbomer 934 to the purified water, stir for more than 1 hour to dissolve completely Aqueous phase is obtained;

[0073] (2) Oil phase preparation: take lidocaine and prilocaine according to the prescription in the main pot, stir and mix evenly at 40-50°C, melt to a transparent liquid, and obtain lidocaine-prilocaine eutectic; Recipe amount of polyoxyethylene 80 hydrogenated castor oil is completely melted at 60°C, then added to the eutectic, stirred evenly to prepare the oil phase for later use;

[0074] (3) Prepare 5% sodium hydroxide solution with purified water according to the prescription quantity; ...

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Abstract

The invention provides a compound lidocaine cream pharmaceutical composition and a preparation method thereof. The pharmaceutical composition is prepared from effective doses of lidocaine and prilocaine as main drug raw materials, and polyoxyethylene hydrogenated castor oil, carbomer, sodium hydroxide and purified water as pharmaceutical auxiliary materials. The cream body of the present invention has good moisturization and applicability, low impurity content, good quality and little skin irritation.

Description

technical field [0001] The invention relates to a compound lidocaine cream pharmaceutical composition and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Local anesthetics refer to drugs that can temporarily and reversibly block the generation and conduction of nerve fiber impulses within the limited range of the body without causing the patient to lose consciousness. [0003] Local anesthetics are divided into the following categories according to clinical usage: topical anesthesia, spinal anesthesia, infiltration and blocking anesthesia, epidural and tailbone anesthesia, etc. Generally, local anesthetics and epinephrine are used together to cause vasoconstriction to increase local drug concentration, prolong and enhance drug efficacy, and reduce systemic toxicity. [0004] The earliest local anesthetic used was cocaine, which was officially used clinically in 1884. Cocaine is highly toxic and addictive, and its aq...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/167A61K47/44A61K47/32A61P23/02
Inventor 赵亮
Owner SICHUAN HAISCO PHARMA CO LTD
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