Notoginsenoside drop pill and preparation method thereof
A technology of panax notoginseng total saponins and glycosides dripping pills, which is applied in the fields of pill delivery, pharmaceutical formula, and medical preparations of non-active ingredients, etc. It can solve problems such as the exploration of dripping pill formation, so as to improve drug efficacy and reduce the generation of air bubbles , The effect of small weight difference
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experiment example 1
[0032] In order to obtain better weight uniformity and faster disintegration time of the prepared drop pills, the present invention studies the dosage and proportion of the drop pill base polyethylene glycol.
[0033] During the preparation of dropping pills, the molten matrix and medicine are cooled and formed in the condensate. With the preparation of dropping pills, the temperature of the upper layer of the condensate will gradually increase, which makes the time for the cooling and forming of the dropping pills prepared in the later stage longer. Cause the increase of dropping pill weight difference. Therefore, in the process of molten liquid cooling, the smaller the specific heat capacity of the molten liquid, the less heat released into the condensed liquid during the process of condensing into dripping pills, the smaller the change in the temperature of the upper layer of the condensed liquid, and the weight of the pellets is reduced. The effect of the difference is als...
experiment example 2
[0057] Since polyethylene glycol 2000 disintegrates quickly in the mouth and has a certain effect of promoting biofilm penetration, in the present invention, in order to increase the absorption rate of Panax notoginseng saponins in the oral cavity, polyethylene glycol 2000 and three The seven total saponins are mixed and subjected to high-speed shearing, so that polyethylene glycol 2000 can wrap the three seven total saponins. Then add polyethylene glycol 4000 and polyethylene glycol 6000, and then carry out high-temperature melting to make dropping pills.
[0058] In this experimental example, the preparation steps of Panax notoginseng saponins dripping pills are as follows: (1) Take 8 parts by mass of polyethylene glycol 2000 and heat it to 80°C in an oil bath to melt it by conventional methods; (2) Mix 10 parts of three Add seven total saponins, mix well, and shear at a high speed at 80°C. The high-speed shearing uses a shear emulsifier, and adjusts the speed to 200-5000r / m...
experiment example 3
[0082] In the experiment, the inventor tried to use higher temperature to melt the mixture of Panax notoginseng saponins and polyethylene glycol, and moved it to the dropping pill machine.
[0083] In the experiment, the inventor unexpectedly found that after increasing the melting temperature by about 20°C, the viscosity of the molten liquid decreases, and only a very low stirring speed is required in the preparation process, and pipetting is performed through a modified pipette, and the three Seven total saponins and polyethylene glycol are fully mixed, thereby reducing the possibility of bubbles in the molten liquid, and the prepared drop pills also meet the requirements of content uniformity in the 2015 edition of the "Chinese Pharmacopoeia". In addition, after further experiments, it was found that the higher melting temperature did not affect the efficacy of the dropping pills.
[0084]In the drop pill preparation method well known to those skilled in the art, after melt...
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