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Color protection preservative solution for pathological tissue specimen

A technology for tissue specimens and antiseptic solutions, which can be used in the preservation, application, and animal husbandry of human or animal bodies. It can solve the problems of hardening, mildew, and yellowing of specimens, and achieve burden reduction, excellent mildew resistance, and long-lasting effects. Effect

Inactive Publication Date: 2017-06-13
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the specimens preserved in formaldehyde solution for a long time will have mildew, yellowing, and hardening of the specimens.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A color-preserving antiseptic solution for pathological tissue specimens, which is prepared by mixing the following raw materials in proportions by weight:

[0022] Laurocapram 1g, edetate disodium zinc salt 1g, menthol 5g, protein cross-linking agent 0.5g, penetrant 1g, potassium sorbate 0.4g, glycerin 10g, sodium hydroxide powder 10g, water 80g.

[0023] The protein cross-linking agent is a combination of malondialdehyde and glyoxal.

[0024] The penetrant is a combination of sodium chloride and sodium nitrate.

Embodiment 2

[0026] A color-preserving antiseptic solution for pathological tissue specimens, which is prepared by mixing the following raw materials in proportions by weight:

[0027] Laurocapram 2.5g, edetate disodium zinc salt 2.5g, menthol 10g, protein cross-linking agent 0.75g, penetrant 1.5g, potassium sorbate 0.7g, glycerin 15g, sodium hydroxide powder 13g, 100g of water.

[0028] The protein cross-linking agent is a combination of glyoxal and succinaldehyde.

[0029] The penetrating agent is a combination of sodium nitrate and potassium chloride.

Embodiment 3

[0031] A color-preserving antiseptic solution for pathological tissue specimens, which is prepared by mixing the following raw materials in proportions by weight:

[0032] Laurocapram 3g, edetate disodium zinc salt 3g, menthol 15g, protein cross-linking agent 1g, penetrant 2g, potassium sorbate 1g, glycerin 20g, sodium hydroxide powder 16g, water 120g.

[0033] The protein cross-linking agent is a combination of malondialdehyde, glyoxal and succinaldehyde.

[0034] The penetrating agent is a combination of sodium chloride, sodium nitrate and potassium chloride.

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Abstract

The invention discloses a color protection preservative solution for a pathological tissue specimen. The color protection preservative solution is prepared by mixing the following raw materials in parts by weight: 1 to 3 parts of laurocapram, 1 to 3 parts of ethylenediaminetetraacetic acid disodiu, 5 to 15 parts of menthol, 0.5 to 1 part of protein cross-linking agents, 1 to 2 parts of penetrating agents, 0.4 to 1 part of potassium sorbate, 10 to 20 parts of glycerol, 10 to 16 parts of sodium hydroxide powder and 80 to 120 parts of water. The color protection preservative solution of the specimen is colorless and transparent liquid without pungent odor; the sterilization, mildewproof and anti-corrosion performance is excellent; the tissue form and color of the original biological specimen are maintained; no volatile substance exists; the effect is durable; the cost can be effectively reduced; toxic and harmful substances are not contained; green and environment-friendly effects are achieved; the environment burden is reduced.

Description

technical field [0001] The invention relates to the technical field of pathological tissue preservation, in particular to a color-preserving antiseptic solution for pathological tissue specimens. Background technique [0002] From the operating room to the pathology department, laboratory surgery, tissue biopsy, histopathology department, gastroscopy department, etc., it is necessary to use specimen color-preserving antiseptic solution for fixing, storing, and retaining samples of tissues or cells. The existing color-preserving antiseptic The liquid is mainly formalin color preserving antiseptic liquid. Formalin specimen color-preserving antiseptic solution has a good fixation effect, which is due to the large amount of formaldehyde combined with the functional groups of the specimen protein, and after long-term storage, it further polymerizes to form paraformaldehyde. This process makes it form a moderate cross-link between protein peptide chains, which can not only kill b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
CPCA01N1/0215
Inventor 曾思恩孙莉陆毓陆明深
Owner GUILIN MEDICAL UNIVERSITY
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