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Minocycline extended-release formulation

A minocycline and slow-release preparation technology, which is applied in the direction of tetracycline active ingredients, medical preparations of non-active ingredients, antibacterial drugs, etc., can solve problems that do not involve copolymer film-forming, drug-loading, and sustained-release properties problems, to achieve good drug release performance, good drug loading performance, and good mechanical strength

Active Publication Date: 2019-10-01
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zheng Zhang [4] et al synthesized a three-block copolymer (polycaprolactone-lactide)-polyethylene glycol-(polycaprolactone-lactide), namely PCLA-PEG-PCLA, which studied the polymer Biosafety performance, degradation performance and barrier function to prevent postoperative adhesions, without involving the film-forming, drug-loading and sustained-release properties of the copolymer

Method used

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  • Minocycline extended-release formulation
  • Minocycline extended-release formulation
  • Minocycline extended-release formulation

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preparation example 2

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Abstract

The invention provides a minocycline slow release preparation, which is characterized by being prepared from degradable biofilms and minocycline, wherein the degradable biofilms are polyethylene glycol-polylactide-polycaprolactone random copolymers obtained by using polyethylene glycol monomethyl ether as an initiator and using L-lactide and Epsilon-caprolactone as monomers through open loop polymerization; the number average molecular weight of the random copolymers is in a range of 8.0*10<4> to 9.0*10<4>; the random copolymers have the structure formula shown as the formula (1) in the description, wherein the ratio of the L-lactide to Epsilon-caprolactone is 3:1.

Description

technical field The present invention relates to a minocycline sustained-release preparation. Background technique Periodontitis is a common dental disease and the main cause of tooth loss in humans. Mechanical treatment is mainly used for mild periodontitis. With the progression of the disease, the periodontal tissue is destroyed more and more seriously, and the periodontal pocket becomes deeper. It is difficult to achieve satisfactory results with mechanical treatment alone, and it is difficult to completely remove the pathogenic bacteria that exist in the gingival tissue or in the dental tissue. In recent years, the application of antibiotics to the treatment of periodontitis has attracted more and more attention, and the treatment of local sustained-release drugs has become a new treatment method. Minocycline hydrochloride is a clinically commonly used local sustained-release drug for periodontitis. It is a high-efficiency, fast-acting, long-acting new semi-synthetic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/65A61K47/34A61P31/04A61P1/02
Inventor 张修银郎美东黄争美王申春马晓飞韩智慧
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE