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Nano drug-carrying system, and preparation and application thereof

A nano-drug loading and system technology, applied in the field of medicine, can solve the problems of low efficiency of monotherapy, poor biocompatibility, poor target recognition, etc., and achieve good magnetothermal treatment effect, consistency and accuracy, and good biocompatibility. Effect

Active Publication Date: 2017-06-13
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Therefore, the technical problem to be solved by the present invention is the inconsistency of drug release in space and time, poor target recognition, poor biocompatibility, and low monotherapy efficiency in the existing suicide gene / prodrug system therapy, and then provide a Multifunctional nano-drug delivery system with good biocompatibility, strong targeting, synergistic release of suicide genes / prodrugs in cells, and combination therapy with multiple methods

Method used

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  • Nano drug-carrying system, and preparation and application thereof
  • Nano drug-carrying system, and preparation and application thereof
  • Nano drug-carrying system, and preparation and application thereof

Examples

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Embodiment 1

[0052] This embodiment provides a nano drug loading system, such as figure 1 As shown, the magnetic-mesoporous silica nanorods are used as the carrier 1, and the prodrug GCV is loaded on the carrier 1, and the junction formed by poly-L-lysine (PLL) and polyethylene glycol (PEG) Branch copolymer PLL-g-PEG, wherein, PLL-g-PEG is also loaded with suicide gene TK, the magnetic-mesoporous silica nanorod carrier 1 is composed of mesoporous silica nanorod 12 and a magnetic Particle 11 composition.

[0053] The length of the mesoporous silica nanorod 12 is 400nm, its diameter is 100nm, and the aperture is 2.8nm; the material of the magnetic particle 11 is Fe 3 o 4 , with a particle size of 80nm and a specific surface area of ​​650m 2 / g, the cumulative pore volume is 0.9cm 3 / g. Magnetic-mesoporous silica nanorod carrier 1 has a magnetic responsiveness of 90 emu / g; mesoporous silica nanorod 12 is loaded with GCV, and the loading is 25%; the loading of suicide gene TK is 10%.

[...

Embodiment 2

[0071] The present embodiment provides a kind of nano-loaded drug system, with magnetic-mesoporous silica nanorods as the carrier, the prodrug GCV is loaded on the carrier, and poly-L-lysine (PLL), polyethylene glycol (PEG) graft copolymer PLL-g-PEG, wherein, PLL-g-PEG is also loaded with a suicide gene TK, the magnetic-mesoporous silica nanorod carrier is composed of mesoporous silica nanorods and one end embedded magnetic particles.

[0072] Mesoporous silica nanorods have a length of 20nm, a diameter of 70nm, and a pore size of 1nm; the material of the magnetic particles is r-Fe 3 o 4 , with a particle size of 50nm and a specific surface area of ​​400m 2 / g, the cumulative pore volume is 0.5cm 3 / g. The magnetic response capability of the magnetic-mesoporous silica nanorod carrier is 57 emu / g; the mesoporous silica nanorod is loaded with GCV, and the loading amount is 5%; the suicide gene TK loading amount is 5%.

[0073] This embodiment also provides a preparation met...

Embodiment 3

[0090] The present embodiment provides a kind of nano-loaded drug system, with magnetic-mesoporous silica nanorods as the carrier, the prodrug GCV is loaded on the carrier, and poly-L-lysine (PLL), polyethylene glycol (PEG) graft copolymer PLL-g-PEG, wherein, PLL-g-PEG is also loaded with a suicide gene TK, the magnetic-mesoporous silica nanorod carrier is composed of mesoporous silica nanorods and one end embedded magnetic particles.

[0091] Mesoporous silica nanorods have a length of 500nm, a diameter of 150mm, and a pore diameter of 5nm; the material of the magnetic particles is MnFe 3 o 4 , with a particle size of 150mm and a specific surface area of ​​1200m 2 / g, the cumulative pore volume is 1.5cm 3 / g. The magnetic response capability of the magnetic-mesoporous silica nanorod carrier is 60 emu / g; the mesoporous silica nanorod is loaded with GCV, and the loading amount is 40%; the suicide gene TK loading amount is 20%.

[0092] This embodiment also provides a prepa...

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Abstract

The invention relates to the technical field of medicine, and provides a nano drug-carrying system. The nano drug-carrying system comprises a magnetic-mesoporous silicon dioxide nanorod carrier, a pro-drug GCV (ganciclovir) carried on the carrier, and a graft copolymer PLL-g-PEG (poly-L-lysine graft polyethylene glycol) formed by PLL and PEG, wherein the PLL-g-PEG also carries a suicide gene TK. The magnetic-mesoporous silicon dioxide nanorods are used as the magnetic targeted carrier to carry the suicide gene TK / pro-drug GCV to enter cells, thereby implementing the time and space consistency of the suicide gene and pro-drug transfer, and further implementing accurate drug release. The magnetic-mesoporous silicon dioxide silicon dioxide nanorods and suicide gene / pro-drug treatment method are effectively combined, thereby enhancing the combined treatment effect on the liver cancer. The preparation method of the nano drug-carrying system is simple in technique and suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a nano drug loading system and its preparation and application. Background technique [0002] Liver cancer is one of the most serious diseases threatening human health, and it is the third most common malignant tumor next to gastric cancer and esophageal cancer. In China, about 110,000 people die from liver cancer every year, accounting for 45% of the world's liver cancer deaths. . Commonly used methods for the treatment of liver cancer include surgery, chemotherapy and radiotherapy, among which chemotherapy is one of the most promising methods and research directions for the treatment of cancer. With the increase of effective chemotherapy drugs and the progress of treatment strategies, the status and proportion of chemotherapy in the comprehensive treatment of liver cancer is increasing day by day. [0003] However, the early diagnosis of liver cancer is currently clinically ...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K31/522A61K41/00A61K47/69A61K9/51A61K47/34A61P35/00
CPCA61K9/5146A61K31/522A61K41/00A61K41/0052A61K48/0033A61K2300/00
Inventor 常智敏董文飞王政葛明锋张翼李力
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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