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Effective components extracted from hazelnut and its application in prevention and treatment of atherosclerosis

A technique for atherosclerosis and extracts, which is applied in the application field of effective extraction of ingredients from Chuanxun, prevention and treatment of atherosclerosis, and can solve the problems such as the lack of in-depth analysis of medicinal effects.

Active Publication Date: 2019-11-05
SHENZHEN KANGDAO BIOLOGY CO LTD
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] At present, various classified compounds have been extracted from hazelnut leaves, such as diaryl heptane compounds and taxane compounds, but the medicinal efficacy of these substances has not been analyzed in depth. On the basis of Chinese hazelnut (Latin name Corylus heterophylla Fisch.exTrautv.var.sutchuenensis Franch.), after a large number of experimental studies, the best extraction method was obtained, and the active ingredients of hazelnut were effectively extracted and separated. And it was found that one of the compounds has a significant effect on vascular protection, especially in the treatment of atherosclerosis, which is significantly higher than other active ingredients, and can be applied to the treatment of atherosclerosis in the future

Method used

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  • Effective components extracted from hazelnut and its application in prevention and treatment of atherosclerosis
  • Effective components extracted from hazelnut and its application in prevention and treatment of atherosclerosis
  • Effective components extracted from hazelnut and its application in prevention and treatment of atherosclerosis

Examples

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Embodiment 1

[0050] Example 1 Extraction of the anti-atherosclerosis active ingredients of Chuan Hazel

[0051] Take 1.5kg of Chuan Hazel leaves, put them in the sun until the leaves become dry, crush them, put them into an extraction container, soak them in 3L of petroleum ether for 2 days, stir them for 2 hours every half day, filter them, and keep the leaves for later use; The leaves are put into the extraction container again, soaked in 2.5L of chloroform extract for 2 days, stirred for 2 hours every half day, filtered, and the leaves are set aside; the filtered leaves are put into the extraction container again, soaked in 2.5L of methanol extract for 3 days , stirred for 2 hours every half day, filtered to obtain the methanol extract, and the methanol solvent was removed by rotary evaporation, crushed to obtain the methanol extract; the obtained methanol extract was put into the extraction container again, and ethyl acetate and methanol were used according to the volume ratio : 3L of ...

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Abstract

The invention relates to a naturally extracted pharmaceutical effective component extracted from leaves of Corylus heterophylla Fisch. var. sutchuenensis; the component can improve SOD (superoxide dismutase) activity and reduce MDA (malondialdehyde) content, can resist oxidative damage, and can also inhibit the protein expression of vascular wall NF-kappaB and relieve vascular wall inflammation, thereby controlling atherosclerosis.

Description

technical field [0001] The invention relates to the technical field of extraction of natural medicines, in particular to an effective extraction component of hazelnut and its application in preventing and treating atherosclerosis. Background technique [0002] Hazelnut, a plant of the genus Corylus in the Betaceae family, is a plant with a wide range of uses. Its kernel nuts are rich in nutrients and have high economic value. They are the main nutritional products, rich in high amounts of healthy lipids, and can be added to chocolate, ice cream, etc. In cuisine, hazelnuts appeared as a food very early in the history of our country. Hazelnut also has rich medicinal effects, such as invigorating the spleen and stomach, benefiting the liver and improving eyesight. It is mainly used to treat symptoms such as weakness after illness, lack of food and fatigue, dim eyesight, weak vision for a long time, insufficient Qi and blood, and malnutrition in children. [0003] In addition ...

Claims

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Application Information

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IPC IPC(8): C07D313/00A61K31/335A61P9/10
CPCA61K31/335A61K36/185C07D313/00
Inventor 赵军民
Owner SHENZHEN KANGDAO BIOLOGY CO LTD
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